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Cited by 608

The DOI matches its Crossref record; 81 of the 81 references it cites were found in a registry or an index.

Hemodynamic actions of insulin

Baron, A. D.·1994·American Journal of Physiology-Endocrinology and Metabolism
DOI 10.1152/ajpendo.1994.267.2.e187
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Abstract

There is accumulating evidence that insulin has a physiological role to vasodilate skeletal muscle vasculature in humans. This effect occurs in a dose-dependent fashion within a half-maximal response of approximately 40 microU/ml. This vasodilating action is impaired in states of insulin resistance such as obesity, non-insulin-dependent diabetes, and elevated blood pressure. The precise physiological role of insulin-mediated vasodilation is not known. Data indicate that the degree of skeletal muscle perfusion can be an important determinant of insulin-mediated glucose uptake. Therefore, it is possible that insulin-mediated vasodilation is an integral aspect of insulin's overall action to stimulate glucose uptake; thus defective vasodilation could potentially contribute to insulin resistance. In addition, insulin-mediated vasodilation may play a role in the regulation of vascular tone. Data are provided to indicate that the pressor response to systemic norepinephrine infusions is increased in obese insulin-resistant subjects. Moreover, the normal effect of insulin to shift the norepinephrine pressor dose-response curve to the right is impaired in these patients. Therefore, impaired insulin-mediated vasodilation could further contribute to the increased prevalence of hypertension observed in states of insulin resistance. Finally, data are presented to indicate that, via a yet unknown interaction with the endothelium, insulin is able to increase nitric oxide synthesis and release and through this mechanism vasodilate. It is interesting to speculate that states of insulin resistance might also be associated with a defect in insulin's action to modulate the nitric oxide system.(ABSTRACT TRUNCATED AT 250 WORDS)

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Metadata

Authors
Baron, A. D.
Venue
American Journal of Physiology-Endocrinology and Metabolism
Publisher
American Physiological Society
Published
1994-08-01
Volume
267
Issue
2
Pages
E187-E202
ISSN
  • 0193-1849 (ISSN-L)
  • 1522-1555
DOI
10.1152/ajpendo.1994.267.2.e187
OpenAlex
W1782741946
Cited by
608
References
81
FWCI
12.38
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Hemodynamic actions of insulin. https://app.cochat.ai/papers/10.1152/ajpendo.1994.267.2.e187
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Baron, A. D. (1994). Hemodynamic actions of insulin. American Journal of Physiology-Endocrinology and Metabolism. https://doi.org/10.1152/ajpendo.1994.267.2.e187

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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