Dietary fat and adiposity: a dose-response relationship in adult male rats fed isocalorically
Abstract
This study examined the effects of increasing levels of dietary fat fed isocalorically on body weight, body composition, and adipose distribution. Adult male rats were weight matched into four groups. One group that was fed a low-fat diet (12%) served as reference controls. The other three groups were fed diets of 24, 36, or 48% fat in amounts to equal the energy intake of the control group. After 6 wk, body weights of the four groups were not significantly different. Intrascapular brown fat did not differ between groups. Total body fat and adipose depot weights, however, increased in proportion to the level of fat in the diet. Total body fat and retroperitoneal and mesenteric depot weights of the 48% fat group were greater than controls (P < 0.05). Mesenteric fat in this group was also significantly increased over all other groups (P < 0.05). These results show that high-fat diets fed to adult animals cause increased body fat in the absence of significant changes in body weight and that mesenteric fat is increased disproportionately.
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High-fat diet can lead to animal obesity and muscle atrophy.
“High-fat diet (HFD) has a higher energy density than a regular diet, which can lead to animal obesity and muscle atrophy.”
From GLP-1RA Liraglutide and Semaglutide Improves Obesity-Induced Muscle Atrophy via SIRT1 Pathway (2023) · cites this paper as [25]
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- Authors
- Boozer, C. N., Schoenbach, G., & Atkinson, R. L.
- Affiliations
- United States Department of Veterans Affairs (US)
- ORCID
- Atkinson, R. L.
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 1995-04-01
- Volume
- 268
- Issue
- 4
- Pages
- E546-E550
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2156757120
- Cited by
- 114
- References
- 18
- Citations by year
- 2024: 2 · 2023: 1 · 2022: 1 · 2021: 6 · 2020: 5 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 5 · 2014: 1 · 2013: 2 · 2012: 6
- FWCI
- 4.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 26687, P30DK026687)
- Topics
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- dietary fat, adiposity, dose-response relationship, isocaloric feeding, body composition, body fat distribution, mesenteric fat, retroperitoneal fat, high-fat diet, body weight, rats
- MeSH terms
- Adipose Tissue, Animals, Blood Glucose, Body Composition, Dietary Fats, Dose-Response Relationship, Drug, Energy Metabolism, Insulin, Male, Oxygen Consumption, Weight Gain, Rats, Sprague-Dawley, Rats
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