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Cited by 149Cardiovascular and exercise physiologyDiabetes, Cardiovascular Risks, and LipoproteinsDiabetes Management and Research

Splanchnic and muscle metabolism during exercise in NIDDM patients

Martin, I. K., Katz, A., Wahren, J.·1995·American Journal of Physiology-Endocrinology and Metabolism
DOI 10.1152/ajpendo.1995.269.3.e583
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Abstract

To characterize splanchnic and muscle metabolism during exercise in non-insulin-dependent diabetes mellitus (NIDDM), eight male nonobese patients and seven healthy control subjects (CON) were studied during 40 min of bicycle exercise at 60% of maximal oxygen uptake. Biopsies were obtained from the quadriceps femoris muscle at rest and immediately after exercise. Arterial glucose concentration in NIDDM had declined by 10% (P < 0.01) at the end of exercise, whereas in CON it had risen by 21% (P < 0.05). Leg glucose uptake rose from 0.19 +/- 0.06 mmol/min at rest to 2.25 +/- 0.61 mmol/min at the end of exercise in NIDDM and from 0.13 +/- 0.05 to 1.17 +/- 0.34 mmol/min in CON. Splanchnic glucose output increased from 0.52 +/- 0.06 to 2.37 +/- 0.26 mmol/min in NIDDM and from 0.79 +/- 0.12 to 2.44 +/- 0.38 mmol/min in CON. Leg lactate output during exercise was twofold higher in NIDDM. Muscle contents of lactate and glycogen were similar in both groups at rest, whereas after exercise lactate tended to be higher (19.5 +/- 1.7 vs. 12.7 +/- 5.9 mmol/kg dry wt) and glycogen lower (154 +/- 35 vs. 251 +/- 41 mmol glucosyl units/kg dry wt) in NIDDM. Whole body respiratory exchange ratio during exercise was higher in NIDDM (0.84 +/- 0.02 vs. 0.78 +/- 0.02, P < 0.05). Exercise-induced changes in other muscle metabolites were similar in NIDDM and CON. These data indicate that the decline in blood glucose during exercise in nonobese NIDDM is due to enhanced peripheral glucose utilization rath…

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Crossref · 10.1152/ajpendo.1995.269.3.e583

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  • In the postabsorptive state, moderate-intensity exercise decreases plasma glucose concentrations and is followed by an increase in insulin sensitivity in NIDDM patients.

    “In the postabsorptive state exercise of moderate intensity has been shown to decrease plasma glucose concentrations and is followed by an increase in insulin sensitivity [1-5].”

    From The effect of moderate exercise on postprandial glucose homeostasis in NIDDM patients (1997) · cites this paper as [5]

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Authors
Martin, I. K., Katz, A., & Wahren, J.
Affiliations
Karolinska University Hospital (SE)
ORCID
Venue
American Journal of Physiology-Endocrinology and Metabolism
Publisher
American Physiological Society
Published
1995-09-01
Volume
269
Issue
3
Pages
E583-E590
ISSN
  • 0193-1849 (ISSN-L)
  • 1522-1555
DOI
10.1152/ajpendo.1995.269.3.e583
OpenAlex
W2339156076
Cited by
149
References
4
Citations by year
2025: 4 · 2024: 1 · 2023: 5 · 2022: 8 · 2021: 11 · 2020: 5 · 2019: 6 · 2018: 11 · 2017: 5 · 2016: 7 · 2015: 9 · 2014: 5 · 2013: 6 · 2012: 7
FWCI
9.13
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords
type 2 diabetes, exercise metabolism, muscle glucose uptake, quadriceps, blood glucose, muscle glycogen, respiratory exchange ratio, peripheral glucose utilization
MeSH terms
Adult, Arteries, Diabetes Mellitus, Type 2, Physical Exertion, Heart, Hormones, Humans, Leg, Male, Middle Aged, Muscles, Respiration, Splanchnic Circulation

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