The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Nitric oxide inhibitor L-NAME suppresses mechanically induced bone formation in rats
Abstract
We hypothesized that nitric oxide may act as an intermediary in the transduction of mechanical loading of bone into a bone formation response. In the present study, 48 rats were divided into the following three treatment groups: control, treatment with N omega-nitro-L-arginine methyl ester (L-NAME; an inhibitor of nitric oxide synthase), and treatment with D-NAME (the less active enantiomer of L-NAME). The rats were subdivided into groups subjected to four-point bending or sham loading of their right tibiae. Bone formation was measured at the midshaft of the loaded and nonloaded (left) tibiae of each rat using histomorphometric methods. The application of four-point bending, but not sham loading, resulted in new bone formation. Treatment with L-NAME reduced the rate of mechanically induced bone formation by 66% compared with the control group. Bone formation rates in nonloaded or sham-loaded limbs were not affected by L-NAME treatment. The results suggest that nitric oxide may play a role in the transduction of a mechanical stimulus into a biological response in bone.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
Palmer, R. M. J., Ferrige, A. G., & Moncada, S. (1987) · Nature · doi:10.1038/327524a0 · Cited by 10,704
Nitric oxide synthases in mammals
Knowles, R. G., & Moncada, S. (1994) · Biochemical Journal · doi:10.1042/bj2980249 · Cited by 2,752
Cited by
Mechanosensation and transduction in osteocytes
Klein-Nulend, J., Bakker, A. D., Bacabac, R. G., Vatsa, A., & Weinbaum, S. (2013) · Bone · doi:10.1016/j.bone.2012.10.013 · Cited by 528
Mechanical Strain and Bone Cell Function: A Review
Ehrlich, P. J., & Lanyon, L. E. (2002) · Osteoporosis International · doi:10.1007/s001980200095 · Cited by 512
Turner, C. H., & Pavalko, F. M. (1998) · Journal of Orthopaedic Science · doi:10.1007/s007760050064 · Cited by 395
Self-citationForwood, M. R. (1996) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650111112 · Cited by 358
From streaming‐potentials to shear stress: 25 years of bone cell mechanotransduction
Riddle, R. C., & Donahue, H. J. (2009) · Journal of Orthopaedic Research · doi:10.1002/jor.20723 · Cited by 157
Metadata
- Authors
- Turner, C. H., Takano, Y., Owan, I., & Murrell, G. A.
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 1996-04-01
- Volume
- 270
- Issue
- 4
- Pages
- E634-E639
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2253282519
- Cited by
- 175
- References
- 2
- FWCI
- 2.97
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Nitric oxide inhibitor L-NAME suppresses mechanically induced bone formation in rats. https://app.cochat.ai/papers/10.1152/ajpendo.1996.270.4.e634
- The paper
- Turner, C. H., Takano, Y., Owan, I., & Murrell, G. A. (1996). Nitric oxide inhibitor L-NAME suppresses mechanically induced bone formation in rats. American Journal of Physiology-Endocrinology and Metabolism. https://doi.org/10.1152/ajpendo.1996.270.4.e634
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
