From streaming‐potentials to shear stress: 25 years of bone cell mechanotransduction
Open accessAbstract
Mechanical loads are vital regulators of skeletal mass and architecture as evidenced by the increase in bone formation following the addition of exogenous loads and loss of bone mass following their removal. While our understanding of the molecular mechanisms by which bone cells perceive changes in their mechanical environment has increased rapidly in recent years, much remains to be learned. Here, we outline the effects of interstitial fluid flow, a potent biophysical signal induced by the deformation of skeletal tissue in response to applied loads, on bone cell behavior. We focus on the molecular mechanisms by which bone cells are hypothesized to perceive interstitial fluid flow, the cell signaling cascades activated by fluid flow, and the use of this signal in tissue engineering protocols. © 2008 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 27:143–149, 2009
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Current thought for how a bone strain of about 0.1% can be amplified to 1-10% is based on 25 years of publications by Riddle and Donahue.
“Current thought for how a bone strain of ~0.1% can be amplified to a 1–10% has been suggested based upon 25 years of publications by Riddle and Donahue (437).”
From Lack of Exercise Is a Major Cause of Chronic Diseases (2012) · cites this paper as [437]
Deformation of skeletal tissues induces pressurization of interstitial fluid, producing a positive pressure gradient from the matrix to the haversian canals, allowing bone cells to perceive changes in their mechanical environment.
“Deformation of skeletal tissues induces pressurization of interstitial fluid, producing a positive pressure gradient from the matrix to the haversian cannels, allowing bone cells perceive changes in their mechanical environment (an amplification mechanism) (437).”
From Lack of Exercise Is a Major Cause of Chronic Diseases (2012) · cites this paper as [437]
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Prisby, R. D. (2020) · Comprehensive physiology · doi:10.1002/j.2040-4603.2020.tb00132.x · Cited by 10 · see citing works
Cellular and molecular mechanotransduction in bone
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Gap Junctions and Biophysical Regulation of Bone Cells
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Mechanical Adaptability of the Skeleton
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Variation of Streaming Potentials with Time under Steady Fluid Pressure in Bone
Liu, J., Hou, Z., Qin, Q., Fu, D., & Pan, S. (2019) · Applied Sciences · doi:10.3390/app9183726 · Cited by 9 · see citing works
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- Authors
- Riddle, R. C., & Donahue, H. J.
- Affiliations
- University of Alabama at Birmingham (US)
- Pennsylvania State University (US)
- Corresponding author
- Donahue, Henry J.
- Venue
- Journal of Orthopaedic Research
- Publisher
- Wiley
- Published
- 2008-08-06
- Volume
- 27
- Issue
- 2
- Pages
- 143-149
- ISSN
- 0736-0266 (ISSN-L)
- 1554-527X
- OpenAlex
- W1990215712
- Cited by
- 157
- References
- 110
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 3 · 2023: 1 · 2022: 9 · 2021: 5 · 2020: 9 · 2019: 9 · 2018: 9 · 2017: 11 · 2016: 5 · 2015: 9 · 2014: 7 · 2013: 18 · 2012: 16
- FWCI
- 0.92
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Orthopaedic Research® (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Pennsylvania
- Pennsylvania State University
- National Institute on Aging (AG-13087, R01AG013087)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR068132)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Keywords
- interstitial fluid flow, bone mechanobiology, mechanical loading, bone formation, bone resorption, bone tissue engineering
- MeSH terms
- Animals, Humans, Osteoblasts, Osteocytes, Stress, Mechanical, Mechanotransduction, Cellular, Extracellular Fluid
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