Cited by 157Cellular Mechanics and InteractionsBone Metabolism and DiseasesBone Tissue Engineering Materials

From streaming‐potentials to shear stress: 25 years of bone cell mechanotransduction

Open access
Riddle, Ryan C., Donahue, Henry J.·2009·Journal of Orthopaedic Research

Abstract

Mechanical loads are vital regulators of skeletal mass and architecture as evidenced by the increase in bone formation following the addition of exogenous loads and loss of bone mass following their removal. While our understanding of the molecular mechanisms by which bone cells perceive changes in their mechanical environment has increased rapidly in recent years, much remains to be learned. Here, we outline the effects of interstitial fluid flow, a potent biophysical signal induced by the deformation of skeletal tissue in response to applied loads, on bone cell behavior. We focus on the molecular mechanisms by which bone cells are hypothesized to perceive interstitial fluid flow, the cell signaling cascades activated by fluid flow, and the use of this signal in tissue engineering protocols. © 2008 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 27:143–149, 2009

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1002/jor.20723

Cites

110 of 110 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Current thought for how a bone strain of about 0.1% can be amplified to 1-10% is based on 25 years of publications by Riddle and Donahue.

    “Current thought for how a bone strain of ~0.1% can be amplified to a 1–10% has been suggested based upon 25 years of publications by Riddle and Donahue (437).”

    From Lack of Exercise Is a Major Cause of Chronic Diseases (2012) · cites this paper as [437]

  • Deformation of skeletal tissues induces pressurization of interstitial fluid, producing a positive pressure gradient from the matrix to the haversian canals, allowing bone cells to perceive changes in their mechanical environment.

    “Deformation of skeletal tissues induces pressurization of interstitial fluid, producing a positive pressure gradient from the matrix to the haversian cannels, allowing bone cells perceive changes in their mechanical environment (an amplification mechanism) (437).”

    From Lack of Exercise Is a Major Cause of Chronic Diseases (2012) · cites this paper as [437]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Riddle, R. C., & Donahue, H. J.
Affiliations
  • University of Alabama at Birmingham (US)
  • Pennsylvania State University (US)
Corresponding author
Donahue, Henry J.
Venue
Journal of Orthopaedic Research
Publisher
Wiley
Published
2008-08-06
Volume
27
Issue
2
Pages
143-149
ISSN
  • 0736-0266 (ISSN-L)
  • 1554-527X
OpenAlex
W1990215712
Cited by
157
References
110
Citations by year
2026: 3 · 2025: 9 · 2024: 3 · 2023: 1 · 2022: 9 · 2021: 5 · 2020: 9 · 2019: 9 · 2018: 9 · 2017: 11 · 2016: 5 · 2015: 9 · 2014: 7 · 2013: 18 · 2012: 16
FWCI
0.92
Type
journal article
Language
en
Open access
Locations
  • Journal of Orthopaedic Research® (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • University of Pennsylvania
  • Pennsylvania State University
  • National Institute on Aging (AG-13087, R01AG013087)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR068132)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
Keywords
interstitial fluid flow, bone mechanobiology, mechanical loading, bone formation, bone resorption, bone tissue engineering
MeSH terms
Animals, Humans, Osteoblasts, Osteocytes, Stress, Mechanical, Mechanotransduction, Cellular, Extracellular Fluid

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review