The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Expression of monocarboxylate transporter MCT1 by brain endothelium and glia in adult and suckling rats
Abstract
A polyclonal affinity-purified antibody to the carboxyl-terminal end of the rat monocarboxylate transporter 1 (MCT1) was generated in chickens and used in immunocytochemical studies of brain tissue sections from adult and suckling rats. The antibody identified a 48-kDa band on immunoblots and stained tissue sections of heart, cecum, kidney, and skeletal muscle, consistent with the reported molecular mass and cellular expression for this transporter. In tissue sections from adult brains, the antibody labeled brain microvessel endothelial cells, ependymocytes, glial-limiting membranes, and neuropil. In brain sections from 3- to 14-day-old rats, microvessels were much more strongly labeled and neuropil was weakly labeled compared with sections from adults. Immunoelectron microscopy indicated that labeling was present on both luminal and abluminal endothelial cell plasma membranes. These results suggest that MCT1 may play an important role in the passage of lactate and other monocarboxylates across the blood-brain barrier and that suckling rats may be especially dependent on this transporter to supply energy substrates to the brain.
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Cited by
Drug Transport across the Blood–Brain Barrier
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Oligodendroglia metabolically support axons and contribute to neurodegeneration
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The neuropharmacology of butyrate: the bread and butter of the microbiota-gut-brain axis
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Supply and demand in cerebral energy metabolism: the role of nutrient transporters
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Metadata
- Authors
- Gerhart, D. Z., Enerson, B. E., Zhdankina, O. Y., Leino, R. L., & Drewes, L. R.
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 1997-07-01
- Volume
- 273
- Issue
- 1
- Pages
- E207-E213
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2172792010
- Cited by
- 299
- References
- 25
- FWCI
- 5.49
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Expression of monocarboxylate transporter MCT1 by brain endothelium and glia in adult and suckling rats. https://app.cochat.ai/papers/10.1152/ajpendo.1997.273.1.e207
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- Gerhart, D. Z., Enerson, B. E., Zhdankina, O. Y., Leino, R. L., & Drewes, L. R. (1997). Expression of monocarboxylate transporter MCT1 by brain endothelium and glia in adult and suckling rats. American Journal of Physiology-Endocrinology and Metabolism. https://doi.org/10.1152/ajpendo.1997.273.1.e207
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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