The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Albumin and fibrinogen syntheses increase while muscle protein synthesis decreases in head-injured patients
Abstract
The effect of trauma on protein metabolism was investigated in the whole body, muscle, and liver in severely head-injured patients presenting an acute inflammatory response by comparison to fed control subjects receiving a similar diet. Nonoxidative leucine disposal (an index of whole body protein synthesis) and muscle, albumin, and fibrinogen synthesis were determined by means of a primed, continuous infusion ofl-[1-13 C]leucine. Nonoxidative leucine disposal increased by 28% in the patients ( P < 0.02). Fractional muscle protein synthesis rate decreased by 50% ( P < 0.01) after injury. Fractional and absolute fribrinogen synthesis rates were multiplied by two and nine, respectively, after injury ( P< 0.001). Albumin levels were lower in patients (25.2 ± 1.2 g/l, means ± SE) than in controls (33.7 ± 1.2 g/l, P < 0.001). However, fractional albumin synthesis rates were increased by 60% in patients (11.4 ± 1.0%/day) compared with controls (7.3 ± 0.4%/day, P < 0.01). Therefore, 1) head trauma induces opposite and large changes of protein synthesis in muscle and acute-phase hepatic proteins, probably mediated by cytokines, glucocorticoids, and other stress hormones, and 2) in these patients, hypoalbuminemia is not due to a depressed albumin synthesis.
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“However, in most disease states in which synthesis rates have been measured, fractional synthesis rate (FSR) in plasma has been reported to be normal or mildly increased (Table 1).63, 64, 65, 66, 67, 68, 69, 70, 71”
From Hypoalbuminemia: Pathogenesis and Clinical Significance (2019) · cites this paper as [67]
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“In clinical practice, all acutely ill or (surgically) traumatized patients have low serum albumin levels.66, 67, 68, 69, 98, 99, 100”
From Hypoalbuminemia: Pathogenesis and Clinical Significance (2019) · cites this paper as [67]
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Ibirogba, S. B., Spearman, C. W., Mall, A. S., Shepherd, E., & Kahn, D. (2005) · PubMed
SKELETAL MUSCLE METABOLISM IN CRITICALLY ILL PATIENTS
Gamrin, L. (2000)
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Barle, H., Essén, P., & Wernerman, J. (1999) · Yearbook of intensive care and emergency medicine · doi:10.1007/978-3-662-13453-5_8
Litvak, N. (2012) · The Atrium (University of Guelph)
Rudar, M. (2016) · The Atrium (University of Guelph)
van Waardenburg, D. A. (2008) · Research Publications (Maastricht University) · doi:10.26481/dis.20080918dw
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Metadata
- Authors
- Mansoor, O., Cayol, M., Gachon, P., Boirie, Y., Schoeffler, P., Obled, C., & Beaufrère, B.
- Affiliations
- Université Clermont Auvergne (FR)
- Institut National de la Recherche Agronomique (FR)
- Laboratoire de Nutrition Humaine, Université d’Auvergne Centre de Recherche en Nutrition Humaine, 63009 Clermont-Ferrand, France
- Centre Hospitalier Universitaire de Clermont-Ferrand (FR)
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 1997-11-01
- Volume
- 273
- Issue
- 5
- Pages
- E898-E902
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W1962005150
- Cited by
- 109
- References
- 32
- Citations by year
- 2026: 1 · 2023: 1 · 2021: 3 · 2019: 2 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 3 · 2012: 4
- FWCI
- 1.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Trauma, Hemostasis, Coagulopathy, Resuscitation
- Keywords
- traumatic brain injury, protein synthesis, albumin synthesis, fibrinogen synthesis, muscle protein synthesis, hypoalbuminemia, acute phase response, hepatic protein synthesis, leucine infusion, cytokines, glucocorticoids, stress hormones, trauma-induced inflammation
- MeSH terms
- Blood Proteins, Calorimetry, Energy Metabolism, Fibrinogen, Craniocerebral Trauma, Humans, Leucine, Liver, Proteins, Reference Values, Serum Albumin, Muscle, Skeletal
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