Effect of pregnancy on the metabolic clearance rate and the volume of distribution of oxytocin in the baboon
Open accessAbstract
Pharmacokinetic parameters of oxytocin (OT) metabolism were determined during the last third of pregnancy and again 4–8 wk after delivery in the baboon. Animals were placed on a tether system with venous and arterial access and a continuous monitoring of uterine contractions during gestation. Two methods of determining OT pharmacokinetics were utilized (bolus injection vs. continuous infusion). The metabolic clearance rate of OT as determined during the bolus trials ( n = 7) was 22.2 ± 1.5 ml ⋅ min−1 ⋅ kg−1 in pregnancy and 16.3 ± 1.4 ml ⋅ min−1 ⋅ kg−1 postpartum ( P < 0.05), respectively, and 23.7 ± 2.8 vs. 16.9 ± 3.7 ml ⋅ min−1 ⋅ kg−1( P < 0.05), respectively, as determined during the 1-h infusion trials ( n = 4). The initial dilution volume and the volume of distribution at steady state of OT after administration did not differ between pregnant and postpartum animals ( P > 0.05). The mean residence time (MRT) of OT was shorter during pregnancy, 7.7 ± 0.8 vs. 10.8 ± 1.2 min postpartum ( P < 0.05). In summary, OT metabolism during pregnancy in the baboon is characterized by 1) increased clearance rate (1.4-fold), 2) accelerated turnover due to the shorter MRT, and 3) unaltered distribution.
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In the baboon, oxytocin clearance was consistent with a two-compartmental system corresponding to the plasma volume and the extravascular fluid volume; the initial half-life in the first phase of distribution was approximately 1 min, followed by a terminal elimination half-life of approximately 10 min.
“In the baboon, oxytocin clearance was also consistent with a two‐compartmental system, corresponding to the plasma volume and the extravascular fluid volume. The initial half‐life in the first phase of distribution was approximately 1 min, followed by a terminal elimination half‐life of approximately 10 min 109.”
From Measuring Oxytocin and Vasopressin: Bioassays, Immunoassays and Random Numbers (2016) · cites this paper as [109]
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Measuring Oxytocin and Vasopressin: Bioassays, Immunoassays and Random Numbers
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“The initial half-life in the first phase of distribution was approximately 1 min, followed by a terminal elimination half-life of approximately 10 min (109).”
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Self-citation
- Authors
- Kowalski, W. B., Diveky, L., Mehendale, R., Parsons, M., & Wilson, L.
- Affiliations
- University of Illinois Chicago (US)
- Departments of Obstetrics and Gynecology, University of Illinois at Chicago, Chicago, Illinois 60612; and
- University of South Florida (US)
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 1998-05-01
- Volume
- 274
- Issue
- 5
- Pages
- E791-E795
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2292806239
- Cited by
- 11
- References
- 15
- Citations by year
- 2021: 1 · 2016: 2 · 2014: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01hd025888-05)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD25888)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy-related medical research
- Health Sciences › Medicine › Obstetrics and Gynecology › Maternal and Perinatal Health Interventions
- Keywords
- oxytocin, pregnancy, postpartum period, pharmacokinetics, metabolic clearance rate, volume of distribution, mean residence time, baboons, uterine contraction, drug metabolism
- MeSH terms
- Animals, Female, Infusions, Intravenous, Metabolic Clearance Rate, Oxytocin, Papio, Pregnancy, Pregnancy, Animal, Postpartum Period
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