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Cited by 48Cardiovascular and exercise physiologyMuscle metabolism and nutritionMetabolism, Diabetes, and Cancer

Epinephrine infusion during moderate intensity exercise increases glucose production and uptake

Kreisman, Stuart H., Mew, Nicholas Ah, Arsenault, Mylène, Nessim, Sharon J., Halter, Jeffrey B., Vranic, Mladen, Marliss, Errol B.·2000·American Journal of Physiology-Endocrinology and Metabolism
DOI 10.1152/ajpendo.2000.278.5.e949
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Abstract

The glucoregulatory response to intense exercise [IE, >80% maximum O 2 uptake (V˙o 2 max)] comprises a marked increment in glucose production (R a) and a lesser increment in glucose uptake (R d), resulting in hyperglycemia. The R a correlates with plasma catecholamines but not with the glucagon-to-insulin (IRG/IRI) ratio. If epinephrine (Epi) infusion during moderate exercise were able to markedly stimulate R a, this would support an important role for the catecholamines' response in IE. Seven fit male subjects (26 ± 2 yr, body mass index 23 ± 0.5 kg/m 2,V˙o 2 max 65 ± 5 ml ⋅ kg− 1 ⋅ min− 1) underwent 40 min of postabsorptive cycle ergometer exercise (145 ± 14 W) once without [control (CON)] and once with Epi infusion [EPI (0.1 μg ⋅ kg− 1 ⋅ min− 1)] from 30 to 40 min. Epi levels reached 9.4 ± 0.8 nM (20× rest, 10× CON). R a increased ∼70% to 3.75 ± 0.53 in CON but to 8.57 ± 0.58 mg ⋅ kg− 1 ⋅ min− 1 in EPI ( P < 0.001). Increments in R a and Epi correlated ( r 2 = 0.923, P ≤ 0.01). In EPI, peak R d (5.55 ± 0.54 vs. 3.38 ± 0.46 mg ⋅ kg− 1 ⋅ min− 1, P = 0.006) and glucose metabolic clearance rate (MCR, P= 0.018) were higher. The R a-to-R d imbalance in EPI caused hyperglycemia (7.12 ± 0.22 vs. 5.59 ± 0.22 mM, P = 0.001) until minute 60 of recovery. A small and late IRG/IRI increase ( P = 0.015 vs. CON) could not account for the R a increase. Norepinephrine (∼4× increase at peak) did not differ between EPI and CON. Thus Epi infusion during moderate exercise led to increments in R a and R d and caused rises of plasma glucose, lactate, and respiratory exchange ratio in fit individuals, supporting a regulatory role for Epi in IE. Epi's effects on R d and MCR during exercise may differ from its effects at rest.

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Authors
Kreisman, S. H., Mew, N. A., Arsenault, M., Nessim, S. J., Halter, J. B., Vranic, M., & Marliss, E. B.
Affiliations
  • Royal Victoria Hospital (CA)
  • University of Michigan (US)
  • Departments of Physiology and Medicine, University of Toronto, Toronto, Ontario, Canada M5S 1A8
ORCID
Venue
American Journal of Physiology-Endocrinology and Metabolism
Publisher
American Physiological Society
Published
2000-05-01
Volume
278
Issue
5
Pages
E949-E957
ISSN
  • 0193-1849 (ISSN-L)
  • 1522-1555
DOI
10.1152/ajpendo.2000.278.5.e949
OpenAlex
W1788185743
Cited by
48
References
41
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 3 · 2014: 1 · 2013: 2 · 2012: 2
FWCI
5.49
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords
epinephrine infusion, moderate-intensity exercise, glucose production, glucose uptake, hyperglycemia, glucoregulation, catecholamines, norepinephrine, glucose metabolic clearance rate, post-exercise recovery, insulin sensitivity, glucagon secretion, insulin resistance
MeSH terms
Adult, Blood Glucose, Epinephrine, Glucagon, Humans, Infusions, Intravenous, Insulin, Male, Metabolic Clearance Rate, Norepinephrine, Oxygen Consumption, Exercise, Pyruvic Acid, Lactic Acid

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