The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Hemodialysis stimulates muscle and whole body protein loss and alters substrate oxidation
Abstract
The hemodialysis (HD) procedure has been implicated as a potential catabolic factor predisposing the chronic HD (CHD) patients to protein calorie malnutrition. To assess the potential effects of HD on protein and energy metabolism, we studied 11 CHD patients 2 h before, during, and 2 h after HD by use of primed constant infusion of l-[1-13 C]leucine andl-[ ring-2 H 5]phenylalanine. Our results showed that HD led to increased whole body (10%) and muscle protein (133%) proteolysis. Simultaneously, whole body protein synthesis did not change, and forearm synthesis increased (120%). The net result was increased net whole body protein loss (96%) and net forearm protein loss (164%). During the 2-h post-HD period, the muscle protein breakdown trended toward baseline, whereas whole body protein breakdown increased further. Substrate oxidation during the post-HD was significantly altered, with diminished carbohydrate and accelerated lipid and amino acid oxidation. These data demonstrate that hemodialysis is an overall catabolic event, decreasing the circulating amino acids, accelerating rates of whole body and muscle proteolysis, stimulating muscle release of amino acids, and elevating net whole body and muscle protein loss.
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Cited by
Carrero, J. J., Stenvinkel, P., Cuppari, L., Ikizler, T. A., Kalantar-Zadeh, K., Kaysen, G., Mitch, W. E., Price, S. R., Wanner, C., Wang, A. Y. M., et al. (2013) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2013.01.001 · Cited by 939
Self-citationProtein nutrition and malnutrition in CKD and ESRD
Zha, Y., & Qian, Q. (2017) · Nutrients · doi:10.3390/nu9030208 · Cited by 292
The role of E3 ubiquitin-ligases MuRF-1 and MAFbx in loss of skeletal muscle mass
Rom, O., & Reznick, A. Z. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.12.031 · Cited by 256
The associations of plant protein intake with all-cause mortality in CKD
Chen, X., Wei, G., Jalili, T., Metos, J., Giri, A., Cho, M. E., Boucher, R., Greene, T., & Beddhu, S. (2016) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2015.10.018 · Cited by 187
Lacson, E., Wang, W., Zebrowski, B., Wingard, R., & Hakim, R. M. (2012) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2012.04.019 · Cited by 149
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Metadata
- Authors
- Ikizler, T. A., Pupim, L. B., Brouillette, J. R., Levenhagen, D. K., Farmer, K., Hakim, R. M., & Flakoll, P. J.
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 2002-01-01
- Volume
- 282
- Issue
- 1
- Pages
- E107-E116
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2137415798
- Cited by
- 326
- References
- 35
- FWCI
- 5.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ikizler, T. A., Pupim, L. B., Brouillette, J. R., Levenhagen, D. K., Farmer, K., Hakim, R. M., & Flakoll, P. J. (2002). Hemodialysis stimulates muscle and whole body protein loss and alters substrate oxidation. American Journal of Physiology-Endocrinology and Metabolism. https://doi.org/10.1152/ajpendo.2002.282.1.e107
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