The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Lipid droplets disrupt mechanosensing in human hepatocytes
Open accessPublished version of a preprint
Abstract
This work examines the impact of lipid loading on mechanosensing by human hepatocytes. In cirrhotic livers, the presence of large (although not small) lipid droplets increased nuclear localization of the mechanotransducer YAP. In primary hepatocytes in culture, lipid droplets led to decreased stiffness-induced cell spreading and disrupted focal adhesions and stress fibers; the presence of large lipid droplets resulted in increased YAP nuclear localization. Collectively, the data suggest that lipid droplets induce intracellular mechanical stress.
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Attenuation of YAP protein nuclear translocation has been previously described in PH.
“Attenuation of YAP protein nuclear translocation has been previously described in PH [39].”
From Mechanical stiffness orchestrates distinct regulation of MRTFs and YAP / TAZ transcriptional cofactors in hepatocytes (2026) · cites this paper as [39]
The ‘Cells with large lipid droplets had increased nuclear YAP’ section reports less nuclear YAP in insulin-only-treated primary human hepatocytes than in controls on glass. It does not establish a general attenuation of YAP nuclear translocation in PH: lipid loading alone left localization unchanged, while large droplets increased nuclear YAP. Page numbers are unavailable in our copy. (LLM, conf=0.72)
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Increased stiffness of the rat liver precedes matrix deposition: implications for fibrosis
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Torres‐Ortiz, B. S., Pérez‐Calixto, D., Carretero‐Ortega, J., Guzman‐López, A. G., Pinto‐Dueñas, D. C., Hernández‐Juárez, M., Jiménez‐Escobar, A., Rodríguez‐Hernández, A., Díaz‐Bello, B., Serna‐Márquez, N., et al. (2026) · The FEBS Journal · doi:10.1111/febs.70570
Metadata
- Authors
- Chin, L., Theise, N. D., Loneker, A. E., Janmey, P. A., & Wells, R. G.
- Affiliations
- National Cancer Institute (US)
- NYU Langone Health (US)
- University of Pennsylvania (US)
- Corresponding author
- Wells, Rebecca G.
- Venue
- American Journal of Physiology-Gastrointestinal and Liver Physiology
- Publisher
- American Physiological Society
- Published
- 2020-07-01
- Volume
- 319
- Issue
- 1
- Pages
- G11-G22
- ISSN
- 0193-1857 (ISSN-L)
- 1522-1547
- PMC
- PMC7468756
- OpenAlex
- W3032227312
- Cited by
- 38
- References
- 4
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 7 · 2023: 11 · 2022: 4 · 2021: 6 · 2020: 1
- FWCI
- 2.74
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- American Journal of Physiology-Gastrointestinal and Liver Physiology (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- NIH (U54-CA193417)
- National Science Foundation (DGE 18345298)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- lipid droplets, mechanosensing, hepatocytes, YAP, nuclear localization, liver cirrhosis, cell stiffness, cell spreading, focal adhesions, stress fibers, mechanotransduction
- MeSH terms
- Cell Nucleus, Carcinoma, Hepatocellular, Humans, Lipids, Liver, Liver Neoplasms, Hepatocytes, Lipid Metabolism, Non-alcoholic Fatty Liver Disease, Lipid Droplets
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