Wells, Rebecca G.

Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells

Schrader, J., Gordon-Walker, T. T., Aucott, R. L., van Deemter, M., Quaas, A., Walsh, S., Benten, D., Forbes, S. J., Wells, R. G., & Iredale, J. P. (2011) · Hepatology

Cellular Mechanics and InteractionsCancer Cells and Metastasis

Cited by 720

Increased stiffness of the rat liver precedes matrix deposition: implications for fibrosis

Georges, P. C., Hui, J.-J., Gombos, Z., McCormick, M. E., Wang, A. Y., Uemura, M., Mick, R., Janmey, P. A., Furth, E. E., & Wells, R. G. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 577

Robust cellular reprogramming occurs spontaneously during liver regeneration

Yanger, K., Zong, Y., Maggs, L. R., Shapira, S. N., Maddipati, R., Aiello, N. M., Thung, S. N., Wells, R. G., Greenbaum, L. E., & Stanger, B. Z. (2013) · Genes & Development

Liver physiology and pathologyDevelopmental Biology and Gene Regulation

Cited by 484

Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations

Affo, S., Nair, A., Brundu, F., Ravichandra, A., Bhattacharjee, S., Matsuda, M., Chin, L., Filliol, A., Wen, W., Song, X., et al. (2021) · Cancer Cell

Cholangiocarcinoma and Gallbladder Cancer StudiesLiver physiology and pathology

Cited by 416

Tissue mechanics and fibrosis

Wells, R. G. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Cellular Mechanics and InteractionsCardiac Fibrosis and Remodeling

Cited by 384

Tumor restriction by type I collagen opposes tumor-promoting effects of cancer-associated fibroblasts

Bhattacharjee, S., Hamberger, F., Ravichandra, A., Miller, M., Nair, A., Affo, S., Filliol, A., Chin, L., Savage, T. M., Yin, D., et al. (2021) · Journal of Clinical Investigation

Cancer Cells and MetastasisCellular Mechanics and Interactions

Cited by 367

Hepatic stellate cells require a stiff environment for myofibroblastic differentiation

Olsen, A. L., Bloomer, S. A., Chan, E. P., Gaça, M. D. A., Georges, P. C., Sackey, B., Uemura, M., Janmey, P. A., & Wells, R. G. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology

Liver physiology and pathologyCellular Mechanics and Interactions

Cited by 355

Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis

Filliol, A., Saito, Y., Nair, A., Dapito, D. H., Yu, L.-X., Ravichandra, A., Bhattacharjee, S., Affo, S., Fujiwara, N., Su, H., et al. (2022) · Nature

Liver physiology and pathologyHepatocellular Carcinoma Treatment and Prognosis

Cited by 349

Long-range force transmission in fibrous matrices enabled by tension-driven alignment of fibers

Wang, H., Abhilash, A. S., Chen, C. S., Wells, R. G., & Shenoy, V. B. (2014) · Biophysical Journal

Cellular Mechanics and InteractionsElasticity and Material Modeling

Cited by 313

Portal fibroblasts: Underappreciated mediators of biliary fibrosis†

Dranoff, J. A., & Wells, R. G. (2010) · Hepatology

Liver physiology and pathologyLiver Diseases and Immunity

Cited by 273

Matrix viscoelasticity promotes liver cancer progression in the pre-cirrhotic liver

Fan, W., Adebowale, K., Váncza, L., Li, Y., Rabbi, M. F., Kunimoto, K., Chen, D., Mozes, G., Chiu, D. K.-C., Li, Y., et al. (2024) · Nature

Cellular Mechanics and InteractionsLiver physiology and pathology

Cited by 263

Stiff matrix induces exosome secretion to promote tumour growth

Wu, B., Liu, D.-A., Guan, L., Myint, P. K., Chin, L., Dang, H., Xu, Y., Ren, J., Li, T., Yu, Z., et al. (2023) · Nature Cell Biology

Extracellular vesicles in diseaseCellular Mechanics and Interactions

Cited by 240

Hepatic stellate cells and portal fibroblasts are the major cellular sources of collagens and lysyl oxidases in normal liver and early after injury

Perepelyuk, M., Terajima, M., Wang, A. Y., Georges, P. C., Janmey, P. A., Yamauchi, M., & Wells, R. G. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 184

Origin and function of myofibroblasts in the liver

Schwabe, R., & Wells, R. (2015) · Seminars in Liver Disease

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 86

Lipid droplets are intracellular mechanical stressors that impair hepatocyte function

Loneker, A. E., Alisafaei, F., Kant, A., Li, D., Janmey, P. A., Shenoy, V. B., & Wells, R. G. (2023) · Proceedings of the National Academy of Sciences

Cellular Mechanics and InteractionsLiver Disease Diagnosis and Treatment

Cited by 54

Lipid droplets disrupt mechanosensing in human hepatocytes

Chin, L., Theise, N. D., Loneker, A. E., Janmey, P. A., & Wells, R. G. (2020) · American Journal of Physiology-Gastrointestinal and Liver Physiology

Hippo pathway signaling and YAP/TAZCellular Mechanics and Interactions

Cited by 38