The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Epidermal growth factor reduces the development of necrotizing enterocolitis in a neonatal rat model
Abstract
Necrotizing enterocolitis (NEC) is the most common gastrointestinal disease of prematurely born infants. Maternal milk plays an important protective role against NEC development and is the major source of epidermal growth factor (EGF) for neonates. The aim of this study was to examine the effect of orally administered EGF on the incidence of NEC in a neonatal rat model. Newborn rats were artificially fed either with growth factor-free rat milk substitute (RMS) or RMS supplemented with 500 ng/ml of EGF (RMS+EGF). Experimental NEC was induced by exposure to asphyxia and cold stress. Development of NEC was evaluated by gross and histological scoring of damage in the ileum. Ileal EGF receptor (EGF-R), EGF, and transforming growth factor-α mRNA expression was assessed by RT competitive-PCR, and the EGF-R was localized by immunohistochemistry. EGF supplementation of formula reduced the incidence and severity of NEC in rats (13/16 RMS vs. 4/13 RMS+EGF). Ileal EGF-R mRNA expression was markedly increased in the RMS group compared with RMS+EGF. Enhanced EGF-R expression in the RMS group was localized predominantly in the epithelial cells of injured ileum. These data suggest a new potential therapeutic approach for the prevention and treatment of NEC.
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Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
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Breast milk and neonatal necrotising enterocolitis
Lucas, A., & Cole, T. J. (1990) · The Lancet · doi:10.1016/0140-6736(90)93304-8 · Cited by 1,585
Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor
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Neonatal Necrotizing Enterocolitis
(1978) · New England Journal of Medicine · doi:10.1056/nejm197802022980519 · Cited by 719
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Postnatal development: coordination of feeding, digestion, and metabolism
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Colostrum and milk-derived peptide growth factors for the treatment of gastrointestinal disorders
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Cited by
Amniotic Fluid: Not Just Fetal Urine Anymore
Underwood, M. A., Gilbert, W. M., & Sherman, M. P. (2005) · Journal of Perinatology · doi:10.1038/sj.jp.7211290 · Cited by 687
Necrotizing enterocolitis: new insights into pathogenesis and mechanisms
Niño, D. F., Sodhi, C. P., & Hackam, D. J. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.119 · Cited by 616
Underwood, M. A., Arriola, J., Gerber, C. W., Kaveti, A., Kalanetra, K. M., Kananurak, A., Bevins, C. L., Mills, D. A., & Dvorak, B. (2014) · Pediatric Research · doi:10.1038/pr.2014.102 · Cited by 107
Metadata
- Authors
- Dvorak, B., Halpern, M. D., Holubec, H., Williams, C. S., McWilliam, D. L., Dominguez, J. A., Stepankova, R., Payne, C. M., & McCuskey, R. S.
- Venue
- American Journal of Physiology-Gastrointestinal and Liver Physiology
- Publisher
- American Physiological Society
- Published
- 2002-01-01
- Volume
- 282
- Issue
- 1
- Pages
- G156-G164
- ISSN
- 0193-1857 (ISSN-L)
- 1522-1547
- OpenAlex
- W2126283900
- Cited by
- 264
- References
- 30
- FWCI
- 9.93
- Type
- journal article
- Language
- en
- Open access
- closed
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- Dvorak, B., Halpern, M. D., Holubec, H., Williams, C. S., McWilliam, D. L., Dominguez, J. A., Stepankova, R., Payne, C. M., & McCuskey, R. S. (2002). Epidermal growth factor reduces the development of necrotizing enterocolitis in a neonatal rat model. American Journal of Physiology-Gastrointestinal and Liver Physiology. https://doi.org/10.1152/ajpgi.00196.2001
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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