The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Neonatal maternal separation predisposes adult rats to colonic barrier dysfunction in response to mild stress
Abstract
Intestinal dysfunction is related to stress and early life events, but the mechanisms are largely unknown. Our aim was to determine whether early trauma predisposes adult rats to intestinal mucosal dysfunction in response to stress. Neonatal Sprague-Dawley rats were individually separated from their mothers for 3 h/day at 4–21 days of age. Between days 80 and 90, separated and control rats were subjected to mild acute stress (30-min water avoidance) or sham stress. Mucosal barrier function and ion transport were assessed in colonic tissues mounted in Ussing chambers. Mild stress increased short-circuit current, conductance, and transepithelial transport of macromolecules in separated rats, while having minimal effects in controls. Pretreatment of the separated rats with a corticotropin-releasing hormone (CRH) antagonist, the peptide α-helical CRH(9–41) injected intraperitoneally 20 min before stress, abolished the stress-induced mucosal changes. Our results indicate that neonatal trauma can induce phenotypic changes in adulthood, including enhanced vulnerability of the gut mucosa to stress via mechanisms involving peripherally located CRH receptors.
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“For example, several studies have demonstrated that stressful stimuli can enhance the permeability of the intestinal epithelium, which allows bacterial antigens to penetrate the gut epithelium and triggers an immune response in the intestinal mucosa.23-27”
From Principles and clinical implications of the brain-gut-enteric microbiota axis (2009) · cites this paper as [26]
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Do early‐life events permanently alter behavioral and hormonal responses to stressors?
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II. Stress and intestinal barrier function
Söderholm, J. D., & Perdue, M. H. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.280.1.g7 · Cited by 467
Self-citationCoutinho, S. V., Plotsky, P. M., Sablad, M., Miller, J. C., Zhou, H., Bayati, A. I., McRoberts, J. A., & Mayer, E. A. (2002) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00240.2001 · Cited by 456
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The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems.
(2015) · PubMed Central · Cited by 2,540
Gut/brain axis and the microbiota
Mayer, E. A., Tillisch, K., & Gupta, A. (2015) · Journal of Clinical Investigation · doi:10.1172/jci76304 · Cited by 1,503
Principles and clinical implications of the brain-gut-enteric microbiota axis
Rhee, S. H., Pothoulakis, C., & Mayer, E. A. (2009) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2009.35 · Cited by 1,342
Messaoudi, M., Lalonde, R., Violle, N., Javelot, H., Desor, D., Nejdi, A., Bisson, J.-F., Rougeot, C., Pichelin, M., Cazaubiel, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114510004319 · Cited by 1,324
Kelly, J. R., Kennedy, P. J., Cryan, J. F., Dinan, T. G., Clarke, G., & Hyland, N. P. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00392 · Cited by 1,110
Metadata
- Authors
- Söderholm, J. D., Yates, D. A., Gareau, M. G., Yang, P.-C., MacQueen, G., & Perdue, M. H.
- Affiliations
- Intestinal Disease Research Program, Department of Pathology and Molecular Medicine, and
- McMaster University (CA)
- Venue
- American Journal of Physiology-Gastrointestinal and Liver Physiology
- Publisher
- American Physiological Society
- Published
- 2002-12-01
- Volume
- 283
- Issue
- 6
- Pages
- G1257-G1263
- ISSN
- 0193-1857 (ISSN-L)
- 1522-1547
- OpenAlex
- W2113258076
- Cited by
- 243
- References
- 37
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 6 · 2023: 9 · 2022: 9 · 2021: 15 · 2020: 9 · 2019: 7 · 2018: 15 · 2017: 6 · 2016: 14 · 2015: 14 · 2014: 18 · 2013: 7 · 2012: 11
- FWCI
- 5.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Gastrointestinal and Liver Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Gastroenterology › Digestive system and related health
- Keywords
- neonatal maternal separation, intestinal barrier, water avoidance stress, corticotropin-releasing factor, CRH receptors, short-circuit current, transepithelial transport, early trauma, stress vulnerability
- MeSH terms
- Animals, Animals, Newborn, Behavior, Animal, Biological Transport, Colonic Diseases, Corticotropin-Releasing Hormone, Electric Conductivity, Epithelium, Female, Intestinal Mucosa, Maternal Deprivation, Peptide Fragments, Stress, Physiological, Weight Gain, Rats, Sprague-Dawley, Receptors, Corticotropin-Releasing Hormone, Rats
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