Cited by 244Gastrointestinal motility and disordersStress Responses and CortisolDigestive system and related health

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Neonatal maternal separation predisposes adult rats to colonic barrier dysfunction in response to mild stress

Söderholm, Johan D., Yates, Derrick A., Gareau, Mélanie G., Yang, Ping-Chang, MacQueen, Glenda, Perdue, Mary H.·2002·American Journal of Physiology-Gastrointestinal and Liver Physiology

DOI 10.1152/ajpgi.00314.2002

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Abstract

Intestinal dysfunction is related to stress and early life events, but the mechanisms are largely unknown. Our aim was to determine whether early trauma predisposes adult rats to intestinal mucosal dysfunction in response to stress. Neonatal Sprague-Dawley rats were individually separated from their mothers for 3 h/day at 4–21 days of age. Between days 80 and 90, separated and control rats were subjected to mild acute stress (30-min water avoidance) or sham stress. Mucosal barrier function and ion transport were assessed in colonic tissues mounted in Ussing chambers. Mild stress increased short-circuit current, conductance, and transepithelial transport of macromolecules in separated rats, while having minimal effects in controls. Pretreatment of the separated rats with a corticotropin-releasing hormone (CRH) antagonist, the peptide α-helical CRH(9–41) injected intraperitoneally 20 min before stress, abolished the stress-induced mucosal changes. Our results indicate that neonatal trauma can induce phenotypic changes in adulthood, including enhanced vulnerability of the gut mucosa to stress via mechanisms involving peripherally located CRH receptors.

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Authors: Söderholm, J. D., Yates, D. A., Gareau, M. G., Yang, P.-C., MacQueen, G., & Perdue, M. H.
Affiliations: Intestinal Disease Research Program, Department of Pathology and Molecular Medicine, and
McMaster University (CA)
ORCID: Söderholm, Johan D.
Gareau, Mélanie G.
Yang, Ping-Chang
MacQueen, Glenda
Venue: American Journal of Physiology-Gastrointestinal and Liver Physiology
Publisher: American Physiological Society
Published: 2002-12-01
Volume: 283
Issue: 6
Pages: G1257-G1263
ISSN: 0193-1857 (ISSN-L)
1522-1547
DOI: 10.1152/ajpgi.00314.2002
OpenAlex: W2113258076
Cited by: 243
References: 37
Citations by year: 2026: 2 · 2025: 7 · 2024: 6 · 2023: 9 · 2022: 9 · 2021: 15 · 2020: 9 · 2019: 7 · 2018: 15 · 2017: 6 · 2016: 14 · 2015: 14 · 2014: 18 · 2013: 7 · 2012: 11
FWCI: 5.81
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Gastrointestinal and Liver Physiology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Gastroenterology › Digestive system and related health
Keywords: neonatal maternal separation, intestinal barrier, water avoidance stress, corticotropin-releasing factor, CRH receptors, short-circuit current, transepithelial transport, early trauma, stress vulnerability
MeSH terms: Animals, Animals, Newborn, Behavior, Animal, Biological Transport, Colonic Diseases, Corticotropin-Releasing Hormone, Electric Conductivity, Epithelium, Female, Intestinal Mucosa, Maternal Deprivation, Peptide Fragments, Stress, Physiological, Weight Gain, Rats, Sprague-Dawley, Receptors, Corticotropin-Releasing Hormone, Rats

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Neonatal maternal separation predisposes adult rats to colonic barrier dysfunction in response to mild stress

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