Cellular zinc is required for intestinal epithelial barrier maintenance via the regulation of claudin-3 and occludin expression

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961

Intestinal mucosal barrier function in health and disease

Turner, J. R. (2009) · Nature reviews. Immunology · doi:10.1038/nri2653 · Cited by 3,952

Occludin: a novel integral membrane protein localizing at tight junctions.

Furuse, M., Hirase, T., Itoh, M., Nagafuchi, A., Yonemura, S., Tsukita, S., & Tsukita, S. (1993) · The Journal of cell biology · doi:10.1083/jcb.123.6.1777 · Cited by 2,580

Claudin-1 and -2: Novel Integral Membrane Proteins Localizing at Tight Junctions with No Sequence Similarity to Occludin

Furuse, M., Fujita, K., Hiiragi, T., Fujimoto, K., & Tsukita, S. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.7.1539 · Cited by 2,100

Regulation of intestinal epithelial permeability by tight junctions

Suzuki, T. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1070-x · Cited by 1,437

Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn’s disease

Zeißig, S., Bürgel, N., Günzel, D., Richter, J. F., Mankertz, J., Wahnschaffe, U., Kroesen, A. J., Zeitz, M., Fromm, M., & Schulzke, J. (2006) · Gut · doi:10.1136/gut.2006.094375 · Cited by 1,218

Complex Phenotype of Mice Lacking Occludin, a Component of Tight Junction Strands

Saitou, M., Furuse, M., Sasaki, H., Schulzke, J.-D., Fromm, M., Takano, H., Noda, T., & Tsukita, S. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.12.4131 · Cited by 1,195

Direct Binding of Three Tight Junction-Associated Maguks, Zo-1, Zo-2, and Zo-3, with the Cooh Termini of Claudins

Itoh, M., Furuse, M., Morita, K., Kubota, K., Saitou, M., & Tsukita, S. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.6.1351 · Cited by 1,151

Zinc and its importance for human health: An integrative review.

Roohani, N., Hurrell, R. F., Kelishadi, R., & Schulin, R. (2013) · Europe PMC (PubMed Central) · Cited by 993

Interferon-γ and Tumor Necrosis Factor-α Synergize to Induce Intestinal Epithelial Barrier Dysfunction by Up-Regulating Myosin Light Chain Kinase Expression

Wang, F., Graham, W. V., Wang, Y., Witkowski, E. D., Schwarz, B. T., & Turner, J. R. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62264-x · Cited by 692

Zinc metabolism in patients with the syndrome of iron deficiency anemia, hepatosplenomegaly, dwarfism, and hypognadism.

Prasad, A. S., Miale, A., FARID, Z., Sandstead, H. H., & Schulert, A. R. (1963) · PubMed · Cited by 586

Identification of substrate recognition determinants for human ERK1 and ERK2 protein kinases.

Gonzalez, F. A., Raden, D. L., & Davis, R. J. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54548-8 · Cited by 448

Occludin regulates macromolecule flux across the intestinal epithelial tight junction barrier

Al–Sadi, R., Khatib, K., Guo, S., Ye, D., Youssef, M., & Ma, T. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00055.2011 · Cited by 420

Zinc deficiency in man

Halsted, J. A., RONAGHY, H. A., Abadi, P., Haghshenass, M., Amirhakemi, G. H., Barakat, R. M., & Reinhold, J. G. (1972) · The American Journal of Medicine · doi:10.1016/0002-9343(72)90169-6 · Cited by 357

Nutrition Assessment of Patients With Inflammatory Bowel Disease

Vagianos, K., Bector, S., McConnell, J. P., & Bernstein, C. N. (2007) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607107031004311 · Cited by 324

Quercetin Enhances Intestinal Barrier Function through the Assembly of Zonnula Occludens-2, Occludin, and Claudin-1 and the Expression of Claudin-4 in Caco-2 Cells

Suzuki, T., & Hara, H. (2009) · Journal of Nutrition · doi:10.3945/jn.108.100867 · Cited by 303

Claudin profiling in the mouse during postnatal intestinal development and along the gastrointestinal tract reveals complex expression patterns.

Holmes, J. L., Itallie, C. V. V., Rasmussen, J. E., & Anderson, J. (2006) · Gene Expression Patterns · doi:10.1016/j.modgep.2005.12.001 · Cited by 297

Supplemental zinc reduced intestinal permeability by enhancing occludin and zonula occludens protein-1 (ZO-1) expression in weaning piglets

Zhang, B., & Guo, Y. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114509289033 · Cited by 280

Zinc Metabolism in Hepatic Dysfunction

Vallée, B. L., Wacker, W. E. C., Bartholomay, A. F., & Robin, E. D. (1956) · New England Journal of Medicine · doi:10.1056/nejm195608302550901 · Cited by 269

Nutritional deficiencies in patients with Crohnʼs disease in remission

Filippi, J., Al-Jaouni, R., Wiroth, J.-B., Hébuterne, X., & Schneider, S. M. (2006) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000206541.15963.c3 · Cited by 262

Unique Role of Junctional Adhesion Molecule-A in Maintaining Mucosal Homeostasis in Inflammatory Bowel Disease

Vetrano, S., Rescigno, M., Cera, M. R., Correale, C., Rumio, C., Doni, A., Fantini, M. C., Sturm, A., Borroni, E. M., Repici, A., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.04.002 · Cited by 254

Claudin-3 acts as a sealing component of the tight junction for ions of either charge and uncharged solutes

Milatz, S., Krug, S. M., Rosenthal, R., Günzel, D., Müller, D., Schulzke, J., Amasheh, S., & Fromm, M. (2010) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2010.07.014 · Cited by 250

PKCη regulates occludin phosphorylation and epithelial tight junction integrity

Suzuki, T., Elias, B. C., Seth, A., Shen, L., Turner, J. R., Giorgianni, F., Desiderio, D. M., Guntaka, R. V., & Rao, R. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802741106 · Cited by 222

Zinc Deficiency Induces Membrane Barrier Damage and Increases Neutrophil Transmigration in Caco-2 Cells1,

Finamore, A., Massimi, M., Devirgiliis, L. C., & Mengheri, E. (2008) · Journal of Nutrition · doi:10.1093/jn/138.9.1664 · Cited by 199

Zinc Supplementation Tightens “Leaky Gut” in Crohn’s Disease

Sturniolo, G. C., Leo, V. D., Ferronato, A., D’Odorico, A., & Renata D'Incà (2001) · Inflammatory Bowel Diseases · doi:10.1097/00054725-200105000-00003 · Cited by 193

A dominant mutant of occludin disrupts tight junction structure and function

Bamforth, S. D., Kniesel, U., Wolburg, H., Engelhardt, B., & Risau, W. (1999) · Journal of Cell Science · doi:10.1242/jcs.112.12.1879 · Cited by 147

Glutamine Treatment Attenuates Endoplasmic Reticulum Stress and Apoptosis in TNBS-Induced Colitis

Crespo, I., San‐Miguel, B., Prause, C., Marroni, N. P., Cuevas, M. J., González‐Gallego, J., & Tuñón, M. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050407 · Cited by 124

Zinc supplementation modifies tight junctions and alters barrier function of CACO-2 human intestinal epithelial layers

Wang, X., Valenzano, M. C., Mercado, J. M., Zurbach, E. P., & Mullin, J. M. (2013) · Digestive Diseases and Sciences · doi:10.1007/s10620-012-2328-8 · Cited by 121

The zinc sensing receptor, ZnR/GPR39, controls proliferation and differentiation of colonocytes and thereby tight junction formation in the colon

Cohen, L., Sekler, I., & Hershfinkel, M. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.262 · Cited by 88

TLR2-induced calpain cleavage of epithelial junctional proteins facilitates leukocyte transmigration

Chun, J., & Prince, A. (2009) · Cell Host & Microbe · doi:10.1016/j.chom.2008.11.009 · Cited by 87

Raf 1 represses expression of the tight junction protein occludin via activation of the zinc-finger transcription factor slug

Wang, Z., Wade, P. A., Mandell, K. J., Akyildiz, A., Parkos, C. A., Mrsny, R. J., & Nusrat, A. (2006) · Oncogene · doi:10.1038/sj.onc.1209902 · Cited by 79

The Role of Zinc and Metallothionein in the Dextran Sulfate Sodium-Induced Colitis Mouse Model

Tran, C. D., Ball, J. M., Sundar, S., Coyle, P. V., & Howarth, G. S. (2007) · Digestive Diseases and Sciences · doi:10.1007/s10620-007-9765-9 · Cited by 69

Pro-inflammatory NF-κB and early growth response gene 1 regulate epithelial barrier disruption by food additive carrageenan in human intestinal epithelial cells

Choi, H. J., Kim, J., Park, S.-H., Do, K. H., Yang, H. J., & Moon, Y. (2012) · Toxicology Letters · doi:10.1016/j.toxlet.2012.04.012 · Cited by 64

Marginal Zinc Deficiency Exacerbates Experimental Colitis Induced by Dextran Sulfate Sodium in Rats

Iwaya, H., Kashiwaya, M., Shinoki, A., Lee, J., Hayashi, K., Hara, H., & Ishizuka, S. (2011) · Journal of Nutrition · doi:10.3945/jn.111.138180 · Cited by 58

Difructose anhydride III and sodium caprate activate paracellular transport via different intracellular events in Caco-2 cells

Suzuki, T., & Hara, H. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.01.044 · Cited by 35

Anti-invasive activity of histone deacetylase inhibitors via the induction of Egr-1 and the modulation of tight junction-related proteins in human hepatocarcinoma cells

Kim, S.-O., Choi, B.-T., Choi, I.-W., Cheong, J., Kim, G., Kwon, T. K., Kim, N., & Choi, Y. H. (2009) · BMB Reports · doi:10.5483/bmbrep.2009.42.10.655 · Cited by 24

Cholesterol efflux stimulates metalloproteinase-mediated cleavage of occludin and release of extracellular membrane particles containing its C-terminal fragments

Casas, E., Barron, C., Francis, S. A., McCormack, J. M., McCarthy, K. M., Schneeberger, E. E., & Lynch, R. D. (2009) · Experimental Cell Research · doi:10.1016/j.yexcr.2009.10.020 · Cited by 20

Regulation of the intestinal barrier by nutrients: The role of tight junctions

Suzuki, T. (2020) · Animal Science Journal · doi:10.1111/asj.13357 · Cited by 796

Zinc signals and immunity

Maywald, M., Wessels, I., & Rink, L. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18102222 · Cited by 309

Prophylactic tributyrin treatment mitigates chronic‐binge ethanol‐induced intestinal barrier and liver injury

Cresci, G., Glueck, B., McMullen, M. R., Xin, W., Allende, D., & Nagy, L. E. (2017) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.13731 · Cited by 146

The Impact of Zinc and Zinc Homeostasis on the Intestinal Mucosal Barrier and Intestinal Diseases

Wan, Y., & Zhang, B. (2022) · Biomolecules · doi:10.3390/biom12070900 · Cited by 128

Nonalcoholic Fatty Liver Disease and the Gut-Liver Axis: Exploring an Undernutrition Perspective

Bauer, K. C., Littlejohn, P. T., Ayala, V., Creus-Cuadros, A., & Finlay, B. B. (2022) · Gastroenterology · doi:10.1053/j.gastro.2022.01.058 · Cited by 127

Zinc supplementation modifies tight junctions and alters barrier function of CACO-2 human intestinal epithelial layers

Wang, X., Valenzano, M. C., Mercado, J. M., Zurbach, E. P., & Mullin, J. M. (2013) · Digestive Diseases and Sciences · doi:10.1007/s10620-012-2328-8 · Cited by 121

Zinc enhances intestinal epithelial barrier function through the PI3K/AKT/mTOR signaling pathway in Caco-2 cells

Shao, Y., Wolf, P. G., Guo, S., Guo, Y., Gaskins, H. R., & Zhang, B. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2017.01.013 · Cited by 175

Intracellular zinc is required for intestinal cell survival signals triggered by the inflammatory cytokine TNFα

Ranaldi, G., Ferruzza, S., Canali, R., Leoni, G., Zalewski, P. D., Sambuy, Y., Perozzi, G., & Murgia, C. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.06.020 · Cited by 47

The study of the molecular structure and function of intestinal epithelial tight junction proteins

Zhongwei, Z. (2005) · Parenteral & Enteral Nutrition

Zinc Supplementation, via GPR39, Upregulates PKCζ to Protect Intestinal Barrier Integrity in Caco-2 Cells Challenged by Salmonella enterica Serovar Typhimurium

Shao, Y., Lei, Z., Wolf, P. G., Gao, Y. Q., Guo, Y., & Zhang, B. (2017) · Journal of Nutrition · doi:10.3945/jn.116.243238 · Cited by 45