Zinc signals and immunity

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

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TAK1 is a ubiquitin-dependent kinase of MKK and IKK

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NFAT proteins: key regulators of T-cell development and function

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Functions of S100 Proteins

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The Antioxidant Properties of Zinc

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PI3K-Akt pathway: Its functions and alterations in human cancer

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Inducing and expanding regulatory T cell populations by foreign antigen

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Disruption of the murine IL-4 gene blocks Th2 cytokine responses

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The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses

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The Zinc Finger-containing Transcription Factors GATA-4, -5, and -6

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Emergency granulopoiesis

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Zinc in Infection and Inflammation

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Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer

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The biological inorganic chemistry of zinc ions

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Antioxidant and anti-inflammatory effects of zinc. Zinc-dependent NF-κB signaling

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Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation

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THE STRUCTURE AND MECHANISM OF PROTEIN PHOSPHATASES: Insights into Catalysis and Regulation

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Toll-like receptor 2–mediated NF-κB activation requires a Rac1-dependent pathway

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Functions of zinc in signaling, proliferation and differentiation of mammalian cells

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Endogenous endonuclease-induced DNA fragmentation: an early event in cell-mediated cytolysis.

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Zinc is a novel intracellular second messenger

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Zinc metabolism in patients with the syndrome of iron deficiency anemia, hepatosplenomegaly, dwarfism, and hypognadism.

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Biochemical Characteristics of Caspases-3, -6, -7, and -8

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CELL CYCLE REGULATION AND APOPTOSIS

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Cutting Edge: IL-2 Is Essential for TGF-β-Mediated Induction of Foxp3+ T Regulatory Cells

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Antioxidant effect of zinc in humans

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Zinc Is a Potent Inhibitor of the Apoptotic Protease, Caspase-3

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Reprogramming of the immune system during zinc deficiency

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The Dynamic Link between the Integrity of the Immune System and Zinc Status

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The role of zinc in caspase activation and apoptotic cell death

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Genetically encoded FRET sensors to monitor intracellular Zn2+ homeostasis

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The Functions of Metallothionein and ZIP and ZnT Transporters: An Overview and Perspective

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Zinc decreases C-reactive protein, lipid peroxidation, and inflammatory cytokines in elderly subjects: a potential implication of zinc as an atheroprotective agent

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Effects of Zinc Deficiency on Th1 and Th2 Cytokine Shifts

Prasad, A. S. (2000) · The Journal of Infectious Diseases · doi:10.1086/315916 · Cited by 396 · see citing works

Overview of Zinc Absorption and Excretion in the Human Gastrointestinal Tract

Krebs, N. F. (2000) · Journal of Nutrition · doi:10.1093/jn/130.5.1374s · Cited by 395 · see citing works

Inhibitory sites in enzymes: Zinc removal and reactivation by thionein

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ZIP8 Regulates Host Defense through Zinc-Mediated Inhibition of NF-κB

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Both CD4+CD25+ and CD4+CD25− Regulatory Cells Mediate Dominant Transplantation Tolerance

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Toll-like receptor–mediated regulation of zinc homeostasis influences dendritic cell function

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Protein tyrosine phosphatases and the immune response

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Serum thymulin in human zinc deficiency

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Activation of the Cooh-Terminal Src Kinase (Csk) by Camp-Dependent Protein Kinase Inhibits Signaling through the T Cell Receptor

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Functional Significance of Zinc-Related Signaling Pathways in Immune Cells

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Toll-like receptor 4 signaling in liver injury and hepatic fibrogenesis

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Krüppel-like factors 4 and 5: the yin and yang regulators of cellular proliferation

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Zinc Coordination Environments in Proteins as Redox Sensors and Signal Transducers

Maret, W. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.1419 · Cited by 308 · see citing works

Roles of Zinc Signaling in the Immune System

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Zinc homeostasis and immunity

Rink, L., & Haase, H. (2006) · Trends in Immunology · doi:10.1016/j.it.2006.11.005 · Cited by 292 · see citing works

Zinc

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Zinc Has an Insulin-Like Effect on Glucose Transport Mediated by Phosphoinositol-3-Kinase and Akt in 3T3-L1 Fibroblasts and Adipocytes

Tang, X.-H., & Shay, N. F. (2001) · The Journal of Nutrition · doi:10.1093/jn/131.5.1414 · Cited by 288 · see citing works

Zinc homeostasis and neurodegenerative disorders

Szewczyk, B. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2013.00033 · Cited by 288 · see citing works

Zinc Signals Are Essential for Lipopolysaccharide-Induced Signal Transduction in Monocytes

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Protein Kinase CK2 in Health and Disease

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Positive and negative regulation of T-cell activation through kinases and phosphatases

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A Zinc Clasp Structure Tethers Lck to T Cell Coreceptors CD4 and CD8

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Negative regulation of T-cell receptor signalling by tyrosine protein kinase p50csk

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Intracellular zinc fluctuations modulate protein tyrosine phosphatase activity in insulin/insulin-like growth factor-1 signaling

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Understanding the mechanisms of zinc-sensing by metal-response element binding transcription factor-1 (MTF-1)

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Effect of Zinc on Cells and Biomembranes

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Emerging and diverse roles of protein kinase C in immune cell signalling

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Multiple impacts of zinc on immune function

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The zinc/thiolate redox biochemistry of metallothionein and the control of zinc ion fluctuations in cell signaling

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Interrelationships between zinc and immune function.

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Zinc transporter ZIP8 (SLC39A8) and zinc influence IFN-γ expression in activated human T cells

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Thiol-Reactive Metal Compounds Inhibit NF-κB Activation by Blocking IκB Kinase

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Zinc transporters and cancer: a potential role for ZIP7 as a hub for tyrosine kinase activation

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Metals on the move: zinc ions in cellular regulation and in the coordination dynamics of zinc proteins

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Modulating the immune response by oral zinc supplementation: a single approach for multiple diseases

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Pathogen recognition and Toll-like receptor targeted therapeutics in innate immune cells

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Structure of the PH domain from Bruton's tyrosine kinase in complex with inositol 1,3,4,5-tetrakisphosphate

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Superoxide-induced Stimulation of Protein Kinase C via Thiol Modification and Modulation of Zinc Content

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Zinc Deficiency Induces Membrane Barrier Damage and Increases Neutrophil Transmigration in Caco-2 Cells1,

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Reprint of Neutrophil cell surface receptors and their intracellular signal transduction pathways

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Identification and Characterization of Zinc Binding Sites in Protein Kinase C

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Zinc can increase the activity of protein kinase C and contributes to its binding to plasma membranes in T lymphocytes.

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Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor–mediated immune responses but not in TCR signaling

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Impact of the discovery of human zinc deficiency on health

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Zinc-suppressed inflammatory cytokines by induction of A20-mediated inhibition of nuclear factor-κB

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Zinc Release from Protein Kinase C as the Common Event during Activation by Lipid Second Messenger or Reactive Oxygen

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The influence of zinc on apoptosis.

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IRAK signalling in cancer

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Zinc suppresses Th17 development via inhibition of STAT3 activation

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Protein Tyrosine Phosphatases as Targets of the Combined Insulinomimetic Effects of Zinc and Oxidants

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Critical role of IL‐2 and TGF‐β in generation, function and stabilization of Foxp3 + CD4 + Treg

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Regulation of T cell receptor signaling by activation-induced zinc influx

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Zinc-induced PTEN Protein Degradation through the Proteasome Pathway in Human Airway Epithelial Cells

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Correlation between zinc status and immune function in the elderly

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Zinc signals promote IL‐2‐dependent proliferation of T cells

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A Reappraisal of the Role of Zinc in Life and Death Decisions of Cells

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Flow cytometric measurement of labile zinc in peripheral blood mononuclear cells

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Picomolar Concentrations of Free Zinc(II) Ions Regulate Receptor Protein-tyrosine Phosphatase β Activity

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Calcium Ion Gradients Modulate the Zinc Affinity and Antibacterial Activity of Human Calprotectin

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Zinc-Dependent Suppression of TNF-α Production Is Mediated by Protein Kinase A-Induced Inhibition of Raf-1, IκB Kinase β, and NF-κB

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Zinc interactions and conserved motifs of the cGMP-binding cGMP-specific phosphodiesterase suggest that it is a zinc hydrolase.

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Zinc-Mediated Inhibition of Cyclic Nucleotide Phosphodiesterase Activity and Expression Suppresses TNF-α and IL-1β Production in Monocytes by Elevation of Guanosine 3′,5′-Cyclic Monophosphate

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Zinc transporter SLC39A10/ZIP10 facilitates antiapoptotic signaling during early B-cell development

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Zinc deficiency increases organ damage and mortality in a murine model of polymicrobial sepsis*

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STAT6 Inhibits TGF-β1-mediated Foxp3 Induction through Direct Binding to the Foxp3 Promoter, Which Is Reverted by Retinoic Acid Receptor

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Role of cellular zinc in programmed cell death: temporal relationship between zinc depletion, activation of caspases, and cleavage of Sp family transcription factors11Abbreviations: Chx, cycloheximide; PARP, poly(ADP-ribose) polymerase; TNFα, tumor necrosis factor alpha; and TPEN: N,N,N′,N′-tetrakis(2-pyridylmethyl)ethylenediamine.

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Zinc and the Immune System

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Estimation of zinc and iron levels in the serum and hair of women with androgenetic alopecia: Case–control study

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The Role of Zinc in the Etiology of Anemia

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Efficacy of zinc glycinate reducing zinc oxide on intestinal health and growth of nursery pigs challenged with F18+ Escherichia coli

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Effects of zinc acquired through the plant-aphid-ladybug food chain on the growth, development and fertility of Harmonia axyridis

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Zinc deficiency leads to reduced interleukin-2 production by active gene silencing due to enhanced CREMα expression in T cells

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A 2-Hydroxy-1-naphthaldehyde Schiff Base for Turn‐on Fluorescence Detection of Zn2+ Based on PET Mechanism

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Maternal serum zinc level is associated with risk of preeclampsia: A systematic review and meta-analysis

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Food bioactives, micronutrients, immune function and COVID-19

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Welcome to the World of Zinc Signaling

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Zap70 Regulates TCR-Mediated Zip6 Activation at the Immunological Synapse

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Zinc Deficiency and Zinc Supplementation in Allergic Diseases

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The Association between Vitamin D and Zinc Status and the Progression of Clinical Symptoms among Outpatients Infected with SARS-CoV-2 and Potentially Non-Infected Participants: A Cross-Sectional Study

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The immunomodulatory role of zinc in asthmatic patients

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SARS-CoV-2 M pro inhibition by a zinc ion: structural features and hints for drug design

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TLR Signals in Epithelial Cells in the Nasal Cavity and Paranasal Sinuses

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Anemia from A to zinc: Hypocupremia in the setting of gastric bypass and zinc excess

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Zinc and selenium indicators and their relation to immunologic and metabolic parameters in male patients with human immunodeficiency virus

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Nutritional Influences on Immunity and Infection

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Intracellular zinc during cell activation and zinc deficiency

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Nanostructured coatings based on metallic nanoparticles as viral entry inhibitor to combat COVID-19

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A ratiometric triazine-based colorimetric and fluorometric sensor for the recognition of Zn 2+ ions and its application in human lung cancer cells

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The Mechanisms of Zinc Action as a Potent Anti-Viral Agent: The Clinical Therapeutic Implication in COVID-19

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Polysaccharide from Atractylodes macrocephala Koidz binding with zinc oxide nanoparticles: Characterization, immunological effect and mechanism

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Health benefits of bluefin tuna consumption: (Thunnus thynnus) as a case study

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Zinc as a Gatekeeper of Immune Function

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Zinc Signals in Inflammation

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Roles of Zinc and Zinc Signaling in Immunity: Zinc as an Intracellular Signaling Molecule

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Zinc Signals in Immunology

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Functional Significance of Zinc-Related Signaling Pathways in Immune Cells

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