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Adrenergic modulation of human colonic motor and sensory function
Abstract
The effects of pharmacological modulation of adrenergic receptors on colonic motor and sensory function are unclear. We studied 40 healthy volunteers in a single-blind design; 12 received saline, and the remaining 28 received either clonidine, yohimbine, phenylephrine, or ritodrine. A barostat-manometric assembly in the left colon recorded drug effects on fasting and postprandial motor function, compliance, and sensation in response to standardized phasic balloon distensions delivered in random order. Clonidine reduced and yohimbine increased fasting, but not postprandial tone, by 63.2 ± 22.3% and 24.8 ± 8.8% (SE), respectively. Clonidine tended to reduce fasting phasic activity in the descending and sigmoid colon. A power exponential model provided the best fit to the compliance curve. Clonidine significantly increased colonic compliance. Clonidine reduced and yohimbine increased colonic perception of pain but not gas sensation during distension. Phenylephrine and ritodrine did not influence colonic motor or sensory function in the present studies. Thus α 2-receptors modulate fasting colonic tone and compliance and alter perception of pain but not gas during mechanical stimulation of the colon.
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“This dose is safe for administration to healthy subjects, elicited a two- to three-fold increase in plasma norepinephrine levels, and stimulated colonic motility in humans (7, 14).”
From Effects of glucagon-like peptide-1, yohimbine, and nitrergic modulation on sympathetic and parasympathetic activity in humans (2008) · cites this paper as [7]
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Metadata
- Authors
- Bharucha, A. E., Camilleri, M., Zinsmeister, A. R., & Hanson, R. B.
- Affiliations
- Gastroenterology Research Unit and
- Mayo Clinic (US)
- Venue
- American Journal of Physiology-Gastrointestinal and Liver Physiology
- Publisher
- American Physiological Society
- Published
- 1997-11-01
- Volume
- 273
- Issue
- 5
- Pages
- G997-G1006
- ISSN
- 0193-1857 (ISSN-L)
- 1522-1547
- OpenAlex
- W2175762975
- Cited by
- 177
- References
- 34
- Citations by year
- 2025: 3 · 2023: 1 · 2022: 1 · 2020: 2 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 12 · 2015: 3 · 2014: 4 · 2013: 9 · 2012: 4
- FWCI
- 5.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Gastrointestinal and Liver Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service (00585)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Surgery › Congenital gastrointestinal and neural anomalies
- Health Sciences › Medicine › Urology › Urinary Bladder and Prostate Research
- Keywords
- adrenergic receptors, colonic motility, clonidine, yohimbine, phenylephrine, ritodrine, alpha2-adrenoceptors, colonic compliance, colonic tone, balloon distension, postprandial motility
- MeSH terms
- Adult, Anxiety, Blood Pressure, Clonidine, Colon, Depression, Female, Gastrointestinal Motility, Heart Rate, Humans, Male, Muscle Contraction, Muscle Tonus, Muscle, Smooth, Phenylephrine, Pressure, Ritodrine, Sensation, Stress, Psychological, Yohimbine, Single-Blind Method, Adrenergic Agents, Postprandial Period
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