Assessment of Functional Gastrointestinal Disease: The Bowel Disease Questionnaire
Open accessAbstract
A need exists for a self-report questionnaire that reliably and accurately measures symptoms and that distinguishes patients with functional gastrointestinal disease from those with other conditions. We have developed such an instrument, the bowel disease questionnaire, and herein describe details of its discriminatory validity. Data from 399 subjects were analyzed. Patients with gastrointestinal symptoms were ultimately diagnosed as having functional gastrointestinal disease (82 with the irritable bowel syndrome and 33 with functional dyspepsia) or organic gastrointestinal disease (N = 101). There were 145 healthy control subjects and 38 patients with a psychiatric disease, somatoform disorder (which includes those with a diagnosis of hypochrondriasis, psychogenic pain, and somatization or conversion disorder). All subjects completed the questionnaire before undergoing an independent diagnostic assessment by experienced physicians. Functional gastrointestinal disease could be distinguished from organic disease, somatoform disorder, and health by using models derived from logistic discriminant analysis. With use of these models, the estimated probability of functional gastrointestinal disease was then calculated. Descriptive symptom scores were of less value than the scores derived from the data sets by logistic discriminant analysis. Age did not significantly affect the responses to the questionnaire items. We conclude that, in the population studied, the bowel disease questionnaire is a valid measure of symptoms of functional gastrointestinal disease, and this instrument may have clinical and research applications.
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Functional GI disorders, anxiety, and depression were excluded by validated screening questionnaires, a clinical interview, and a physical examination.
“Functional GI disorders, anxiety, and depression were excluded by validated screening questionnaires (46), a clinical interview, and a physical examination.”
From Effects of glucagon-like peptide-1, yohimbine, and nitrergic modulation on sympathetic and parasympathetic activity in humans (2008) · cites this paper as [46]
The Conclusion (p. 12) says the bowel disease questionnaire could distinguish functional gastrointestinal disorders from other conditions, supporting its use as a screening instrument. The paper does not establish it as a validated screen for anxiety or depression; the appendix (p. 22) lists depression as a symptom item, not a diagnosis. The citation is attached to the questionnaires, so the clinical interview and physical examination are not assessed here. (LLM, conf=0.85)
Experimental — accuracy not yet measuredThe Talley Bowel Disease Questionnaire is a reliable and valid measure of GI symptoms.
“The Talley BDQ has been shown to be a reliable and valid measure of GI symptoms (31).”
From Psychosocial Distress and Somatic Symptoms in Community Subjects With Irritable Bowel Syndrome: A Psychological Component Is the Rule (2009) · cites this paper as [31]
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Self-citation
- Authors
- TALLEY, N. J., PHILLIPS, S. F., WILTGEN, C. M., ZINSMEISTER, A. R., & MELTON, L. J.
- Affiliations
- Mayo Clinic (US)
- Venue
- Mayo Clinic Proceedings
- Publisher
- Elsevier BV
- Published
- 1990-11
- Volume
- 65
- Issue
- 11
- Pages
- 1456-1479
- ISSN
- 0025-6196 (ISSN-L)
- OpenAlex
- W2140255850
- Cited by
- 330
- References
- 24
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 3 · 2023: 4 · 2022: 1 · 2021: 13 · 2020: 5 · 2019: 3 · 2018: 6 · 2017: 4 · 2016: 9 · 2015: 10 · 2014: 13 · 2013: 10 · 2012: 14
- FWCI
- 1.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Mayo Clinic Proceedings (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Keywords
- functional gastrointestinal disorders, irritable bowel syndrome, functional dyspepsia, somatoform disorders, health anxiety, psychogenic pain, conversion disorder, somatization, diagnostic validity, logistic discriminant analysis, symptom assessment, questionnaire development
- MeSH terms
- Adult, Aged, Diagnosis, Differential, Female, Gastrointestinal Diseases, Humans, Male, Middle Aged, Surveys and Questionnaires, Regression Analysis, Somatoform Disorders, Reproducibility of Results
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