Adrenergic modulation of human colonic motor and sensory function

The Hospital Anxiety and Depression Scale

Zigmond, A. S., & Snaith, R. P. (1983) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1983.tb09716.x · Cited by 47,139

Altered rectal perception is a biological marker of patients with irritable bowel syndrome

Mertz, H., Naliboff, B. D., Munakata, J., Niazi, N., & Mayer, E. A. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90267-8 · Cited by 976

Distribution of α2 agonist binding sites in the rat and human central nervous system: Analysis of some functional, anatomic correlates of the pharmacologic effects of clonidine and related adrenergic agents

Unnerstall, J. R., Kopajtic, T. A., & Kuhar, M. J. (1984) · Brain Research Reviews · doi:10.1016/0165-0173(84)90030-4 · Cited by 708

Yohimbine: a pharmacological probe for study of the alpha 2-adrenoreceptor.

Goldberg, M. R., & Robertson, D. (1983) · PubMed · Cited by 438

Assessment of Functional Gastrointestinal Disease: The Bowel Disease Questionnaire

TALLEY, N. J., PHILLIPS, S. F., WILTGEN, C. M., ZINSMEISTER, A. R., & MELTON, L. J. (1990) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(12)62169-7 · Cited by 330

Motility of the pelvic colon

Connell, A. M., Jones, F. A., & Rowlands, E. N. (1965) · Gut · doi:10.1136/gut.6.2.105 · Cited by 211

Treatment of Diabetic Diarrhea with Clonidine

Fedorak, R. N., FIELD, M., & CHANG, E. B. (1985) · Annals of Internal Medicine · doi:10.7326/0003-4819-102-2-197 · Cited by 190

Gastric tone determines the sensitivity of the stomach to distention

Notivol, R., Coffin, B., Azpiroz, F., Mearin, F., Serra, J., & Malagelada, J. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90057-8 · Cited by 175

The gastrocolic response: Evidence for a neural mechanism

Snape, W. J., Wright, S., Battle, W. M., & Cohen, S. (1979) · Gastroenterology · doi:10.1016/0016-5085(79)90162-8 · Cited by 170

A double-blind controlled trial of oral-pulse methotrexate therapy in the treatment of primary sclerosing cholangitis

Knox, T. A., & Kaplan, M. M. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90610-6 · Cited by 169

AGA technical review on irritable bowel syndrome.

Drossman, D. A., Camilleri, M., Mayer, E. A., & Whitehead, W. E. (2002) · Gastroenterology · doi:10.1053/gast.2002.37095 · Cited by 1,384

Interactions between the cardiovascular and pain regulatory systems: an updated review of mechanisms and possible alterations in chronic pain

Bruehl, S. P., & Chung, O. Y. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.06.004 · Cited by 377

Management of the irritable bowel syndrome

Camilleri, M. (2001) · Gastroenterology · doi:10.1053/gast.2001.21908 · Cited by 346

Altered visceral perceptual and neuroendocrine response in patients with irritable bowel syndrome during mental stress

Posserud, I., Agerforz, P., Ekman, R., Björnsson, E. S., Abrahamsson, H., & Simrén, M. (2004) · Gut · doi:10.1136/gut.2003.017962 · Cited by 292

American Neurogastroenterology and Motility Society consensus statement on intraluminal measurement of gastrointestinal and colonic motility in clinical practice

Camilleri, M., Bharucha, A. E., Lorenzo, C. D., Hasler, W. L., Prather, C. M., Rao, S. S. C., & Wald, A. M. (2008) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2008.01230.x · Cited by 257

Prospective Study of Motor, Sensory, Psychologic, and Autonomic Functions in Patients With Irritable Bowel Syndrome

Camilleri, M., McKinzie, S., Busciglio, I. A., Low, P. A., Sweetser, S. R., Burton, D. D., Baxter, K. L., Ryks, M. D., & Zinsmeister, A. R. (2008) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2008.02.060 · Cited by 244

G-protein β3 subunit 825 CC genotype is associated with unexplained (functional) dyspepsia 1 ☆

Holtmann, G., Siffert, W., Haag, S., Mueller, N., Langkafel, M., Senf, W., Zotz, R. B., & Talley, N. J. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.01.006 · Cited by 213

Stress and visceral pain: From animal models to clinical therapies

Larauche, M. H., Mulak, A., & Taché, Y. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.04.020 · Cited by 219

Visceral hypersensitivity: facts, speculations, and challenges

Camilleri, M., COULIE, B., & Tack, J. F. (2001) · Gut · doi:10.1136/gut.48.1.125 · Cited by 204

The selective serotonin reuptake inhibitor fluoxetine does not change rectal sensitivity and symptoms in patients with irritable bowel syndrome: A double blind, randomized, placebo-controlled study

Kuiken, S. D., Tytgat, G. N. J., & Boeckxstaens, G. E. (2003) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(03)70039-1 · Cited by 206

Modulation of gastric sensory and motor functions by nitrergic and α2-adrenergic agents in humans

Thumshirn, M., Camilleri, M., Choi, M., & Zinsmeister, A. R. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70179-4 · Cited by 186

Association of distinct α 2 adrenoceptor and serotonin transporter polymorphisms with constipation and somatic symptoms in functional gastrointestinal disorders

Kim, H. J., Camilleri, M., Carlson, P. J., Cremonini, F., Ferber, I., Stephens, D. A., McKinzie, S., Zinsmeister, A. R., & Urrutia, R. A. (2004) · Gut · doi:10.1136/gut.2003.030882 · Cited by 176

First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques

Corsetti, M., Costa, M., Bassotti, G., Bharucha, A. E., Borrelli, O., Dinning, P. G., Lorenzo, C. D., Huizinga, J. D., Jiménez, M., Rao, S. S. C., et al. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0167-1 · Cited by 161

The β3-adrenoceptor as a therapeutic target: Current perspectives

Ursino, M. G., Vasina, V. I., Raschi, E., Crema, F., & Ponti, F. D. (2009) · Pharmacological Research · doi:10.1016/j.phrs.2009.01.002 · Cited by 161

Cholinergic stimulation enhances colonic motor activity, transit, and sensation in humans

Law, N., Bharucha, A. E., Undale, A. S., & Zinsmeister, A. R. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.281.5.g1228 · Cited by 147

Insights into the Pathophysiology and Mechanisms of Constipation, Irritable Bowel Syndrome, and Diverticulosis in Older People

Camilleri, M., Lee, J. S., Viramontes, B. E., Bharucha, A. E., & Tangalos, E. G. (2000) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2000.tb04793.x · Cited by 144

Review article: modulation of the brain–gut axis as a therapeutic approach in gastrointestinal disease

Mayer, E. A., Tillisch, K., & Bradesi, S. (2006) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.03078.x · Cited by 139

Consensus report: clinical perspectives, mechanisms, diagnosis and management of irritable bowel syndrome

Camilleri, M., Heading, R. C., & Thompson, W. (2002) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2002.01305.x · Cited by 136

Effects of glucagon-like peptide-1(7–36)amide on motility and sensation of the proximal stomach in humans

Schirra, J., Wank, U., Arnold, R., Göke, B., & Katschinski, M. (2002) · Gut · doi:10.1136/gut.50.3.341 · Cited by 130

Role of tension receptors in dyspeptic patients with hypersensitivity to gastric distention

Tack, J. F., Caenepeel, P., Corsetti, M., & Janssens, J. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.07.005 · Cited by 129

High amplitude propagated contractions

Bharucha, A. E. (2012) · Neurogastroenterology & Motility · doi:10.1111/nmo.12019 · Cited by 119

Irritable Bowel Syndrome: Methods, Mechanisms, and Pathophysiology. Genetic epidemiology and pharmacogenetics in irritable bowel syndrome

Camilleri, M., & Katzka, D. A. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00537.2011 · Cited by 117

Topical phenylephrine increases anal canal resting pressure in patients with faecal incontinence

Cheetham, M., Kamm, M. A., & Phillips, R. K. S. (2001) · Gut · doi:10.1136/gut.48.3.356 · Cited by 113

Treatment With Hypnotherapy Reduces the Sensory and Motor Component of the Gastrocolonic Response in Irritable Bowel Syndrome

Simrén, M., Ringström, G., Björnsson, E. S., & Abrahamsson, H. (2004) · Psychosomatic Medicine · doi:10.1097/01.psy.0000116964.76529.6e · Cited by 111

Effects of a cannabinoid receptor agonist on colonic motor and sensory functions in humans: a randomized, placebo-controlled study

Esfandyari, T., Camilleri, M., Busciglio, I. A., Burton, D. D., Baxter, K. L., & Zinsmeister, A. R. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00565.2006 · Cited by 112

A Study of Candidate Genotypes Associated with Dyspepsia in a U.S. Community

Camilleri, C. E., Carlson, P. J., Camilleri, M., Castillo, E. J., Locke, G. R., Geno, D. M., Stephens, D. A., Zinsmeister, A. R., & Urrutia, R. A. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00481.x · Cited by 107

Effects of a κ-opioid agonist, asimadoline, on satiation and GI motor and sensory functions in humans

Delgado-Aros, S., Chial, H. J., Camilleri, M., Szarka, L. A., Weber, F. T., Jacob, J., Ferber, I. J., McKinzie, S., Burton, D. D., & Zinsmeister, A. R. (2003) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00360.2002 · Cited by 108

Manometric, Sensorimotor, and Neurophysiologic Evaluation of Anorectal Function

Scott, S. M., & Gladman, M. A. (2008) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2008.06.010 · Cited by 103

Manometric techniques for the evaluation of colonic motor activity: current status

Scott, S. M. (2003) · Neurogastroenterology & Motility · doi:10.1046/j.1365-2982.2003.00434.x · Cited by 100

Pharmacogenetic Trial of a Cannabinoid Agonist Shows Reduced Fasting Colonic Motility in Patients With Nonconstipated Irritable Bowel Syndrome

Wong, B. S., Camilleri, M., Busciglio, I., Carlson, P., Szarka, L. A., Burton, D., & Zinsmeister, A. R. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.07.036 · Cited by 100

Effects of glucagon-like peptide-1, yohimbine, and nitrergic modulation on sympathetic and parasympathetic activity in humans

Bharucha, A. E., Charkoudian, N., Andrews, C. N., Camilleri, M., Sletten, D., Zinsmeister, A. R., & Low, P. A. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00153.2008 · Cited by 98

Phenotypic Variation of Colonic Motor Functions in Chronic Constipation

Ravi, K., Bharucha, A. E., Camilleri, M., Rhoten, D., Bakken, T., & Zinsmeister, A. R. (2010) · Gastroenterology · doi:10.1053/j.gastro.2009.07.057 · Cited by 92

Surgical autonomic denervation results in altered colonic motility: an explanation for low anterior resection syndrome?

Lee, W. Y., Takahashi, T., Pappas, T. N., Mantyh, C. R., & Ludwig, K. A. (2008) · Surgery · doi:10.1016/j.surg.2008.03.014 · Cited by 94

Effects of an α2-adrenergic agonist on gastrointestinal transit, colonic motility, and sensation in humans

Viramontes, B. E., Malcolm, A., Camilleri, M., Szarka, L. A., McKinzie, S., Burton, D. D., & Zinsmeister, A. R. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.281.6.g1468 · Cited by 93

A randomized, controlled exploratory study of clonidine in diarrhea-predominant irritable bowel syndrome

Camilleri, M., Kim, D.-Y., McKinzie, S., Kim, H. J., Thomforde, G. M., Burton, D. D., Low, P. A., & Zinsmeister, A. R. (2003) · Clinical Gastroenterology and Hepatology · doi:10.1053/cgh.2003.50019 · Cited by 90

Effects of a serotonin 5-HT 4 receptor antagonist SB-207266 on gastrointestinal motor and sensory function in humans

Bharucha, A. E., Camilleri, M., Haydock, S., Ferber, I., Burton, D., Cooper, S., Tompson, D., Fitzpatrick, K., Higgins, R., & Zinsmeister, A. R. (2000) · Gut · doi:10.1136/gut.47.5.667 · Cited by 90

Irritable bowel syndrome

Talley, N. J. (2006) · Internal Medicine Journal · doi:10.1111/j.1445-5994.2006.01217.x · Cited by 87

Review article: colonic sensorimotor physiology in health, and its alteration in constipation and diarrhoeal disorders

Camilleri, & Ford (1998) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.1998.00305.x · Cited by 85

Effects of venlafaxine, buspirone, and placebo on colonic sensorimotor functions in healthy humans

Chial, H. J., Camilleri, M., Ferber, I. J., Delgado-Aros, S., Burton, D. D., McKinzie, S., & Zinsmeister, A. R. (2003) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(03)70038-x · Cited by 84

Rectal visceral sensitivity in healthy volunteers: influences of gender, age and methods

Sloots, Felt-Bersma, R. J. F., Cuesta, & Meuwissen, S. G. M. (2000) · Neurogastroenterology & Motility · doi:10.1046/j.1365-2982.2000.00210.x · Cited by 80

Colonic Migrating Motor Complexes, High Amplitude Propagating Contractions, Neural Reflexes and the Importance of Neuronal and Mucosal Serotonin

Smith, T., Park, K., & Hennig, G. (2014) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm14092 · Cited by 113

Barostat testing of rectal sensation and compliance in humans: comparison of results across two centres and overall reproducibility

Cremonini, F., Houghton, L. A., Camilleri, M., Ferber, I., Fell, C., Cox, V., Castillo, E. J., Alpers, D., Dewit, O., Gray, E., et al. (2005) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2005.00709.x · Cited by 80

Baroreflex sensitivity associated hypoalgesia in healthy states is altered by chronic pain

Chung, O. Y., Bruehl, S. P., Diedrich, L., Diedrich, A., Chont, M., & Robertson, D. (2008) · Pain · doi:10.1016/j.pain.2007.11.011 · Cited by 76

Irritable Bowel Syndrome

Andresen, V., & Camilleri, M. (2006) · Drugs · doi:10.2165/00003495-200666080-00004 · Cited by 77

High body mass alters colonic sensory-motor function and transit in humans

Delgado-Aros, S., Camilleri, M., Garcia, M. A., Burton, D. D., & Busciglio, I. A. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90286.2008 · Cited by 73

Towards identifying optimal doses for alpha‐2 adrenergic modulation of colonic and rectal motor and sensory function

Malcolm, A., Camilleri, Kost, Burton, Fett, & Zinsmeister, A. R. (2000) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2000.00757.x · Cited by 71

Day‐to‐day reproducibility of anorectal sensorimotor assessments in healthy subjects

Bharucha, A. E., Seide, B. M., Fox, J. C., & Zinsmeister, A. R. (2004) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2004.00499.x · Cited by 68

The Role of the Barostat in Human Research and Clinical Practice

P. J. van der Schaar, C. B. H. W. L. (1999) · Scandinavian Journal of Gastroenterology · doi:10.1080/003655299750025552 · Cited by 67

Serotonergic and non‐serotonergic targets in the pharmacotherapy of visceral hypersensitivity

Bueno, L., De Ponti, F., Fried, M., Kullak‐ublick, G. A., Kwiatek, M. A., Pohl, D., Quigley, E. M. M., Tack, J., & Talley, N. J. (2007) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2006.00876.x · Cited by 64

Cannabinoid receptor 1 gene and irritable bowel syndrome: phenotype and quantitative traits

Camilleri, M., Kolar, G. J., Vázquez‐Roque, M. I., Carlson, P., Burton, D. D., & Zinsmeister, A. R. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00376.2012 · Cited by 64

Candidate genes and sensory functions in health and irritable bowel syndrome

Camilleri, M., Busciglio, I. A., Carlson, P., McKinzie, S., Burton, D. D., Baxter, K. L., Ryks, M. D., & Zinsmeister, A. R. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90202.2008 · Cited by 66

Common Functional Gastroenterological Disorders Associated With Abdominal Pain

Bharucha, A. E., Chakraborty, S., & Sletten, C. D. (2016) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2016.06.003 · Cited by 68

Effects of pregabalin on visceral pain responses and colonic compliance in rats

Ravnefjord, A., Brusberg, M., Larsson, H., Lindström, E., & Martı́nez, V. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.259 · Cited by 64

Updates on treatment of irritable bowel syndrome

Hammerle, C. W., & Surawicz, C. M. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.2639 · Cited by 65

Treating irritable bowel syndrome: overview, perspective and future therapies

Camilleri, M. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705741 · Cited by 64

Testing the sensitivity hypothesis in practice: tools and methods, assumptions and pitfalls

Camilleri, M. (2002) · Gut · doi:10.1136/gut.51.suppl_1.i34 · Cited by 65

Measurement of Gastrointestinal and Colonic Motor Functions in Humans and Animals

Camilleri, M., & Linden, D. (2016) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2016.04.003 · Cited by 55

Viscoelastic properties of the human colon

Bharucha, A. E., Hubmayr, R. D., Ferber, I. J., & Zinsmeister, A. R. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.281.2.g459 · Cited by 60

Serotonergic modulating drugs for functional gastrointestinal diseases

Spiller, R. E. (2002) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.2002.01612.x · Cited by 60

Gastric electrical stimulation at proximal stomach induces gastric relaxation in dogs

Xing, J. H., Brody, F. J., Brodsky, J. A., Larive, B., Ponsky, J. L., & Soffer, E. E. (2003) · Neurogastroenterology & Motility · doi:10.1046/j.1365-2982.2003.00385.x · Cited by 60

Visceral Hypersensitivity

Delgado-Aros, S., & Camilleri, M. (2005) · Journal of Clinical Gastroenterology · doi:10.1097/01.mcg.0000156114.22598.1b · Cited by 58

Rectal and colonic distension elicit viscerovisceral reflexes in humans

Law, N., Bharucha, A. E., & Zinsmeister, A. R. (2002) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00359.2001 · Cited by 56

Effects of alosetron on gastrointestinal transit time and rectal sensation in patients with irritable bowel syndrome

Thumshirn, Coulie, Camilleri, Zinsmeister, Burton, & Dyke, V. (2000) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2000.00786.x · Cited by 55

Irritable pouch syndrome is characterized by visceral hypersensitivity

Shen, B., Sanmiguel, C. P., Bennett, A. E., Lian, L., Larive, B., Remzi, F. H., Fazio, V. W., & Soffer, E. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21412 · Cited by 52

Neonatal gastric suctioning results in chronic visceral and somatic hyperalgesia: role of corticotropin releasing factor

Smith, C. R., Nordstrom, E. M., Sengupta, J. N., & Miranda, A. (2007) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2007.00949.x · Cited by 52

Effects of Clonidine in Women With Fecal Incontinence

Bharucha, A. E., Fletcher, J. G., Camilleri, M., Edge, J., Carlson, P., & Zinsmeister, A. R. (2013) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2013.06.035 · Cited by 50

Current and novel therapeutic options for irritable bowel syndrome management

Camilleri, M., & Andresen, V. (2009) · Digestive and Liver Disease · doi:10.1016/j.dld.2009.07.009 · Cited by 48

Coloanal motor coordination in association with high-amplitude colonic contractions after pharmacological stimulation

Malcolm, A., & Camilleri, M. (2000) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2000.01840.x · Cited by 48

Rectal sensorimotor dysfunction in women with fecal incontinence

Andrews, C. N., Bharucha, A. E., Seide, B., & Zinsmeister, A. R. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00176.2006 · Cited by 48

Effect of the NK3 receptor antagonist, talnetant, on rectal sensory function and compliance in healthy humans

Houghton, L. A., Cremonini, F., Camilleri, M., Busciglio, I., Fell, C., Cox, V., Alpers, D. H., Dewit, O., Dukes, G. E., Gray, E., et al. (2007) · Neurogastroenterology and Motility · doi:10.1111/j.1365-2982.2007.00934.x · Cited by 46

Mechanisms of Disease: genetics of functional gastrointestinal disorders—searching the genes that matter

Adam, B., Liebregts, T., & Holtmann, G. (2007) · Nature Clinical Practice Gastroenterology & Hepatology · doi:10.1038/ncpgasthep0717 · Cited by 44

The relationship between resting blood pressure and acute pain sensitivity: effects of chronic pain and alpha-2 adrenergic blockade

Bruehl, S. P., Chung, O. Y., Diedrich, L., Diedrich, A., & Robertson, D. (2007) · Journal of Behavioral Medicine · doi:10.1007/s10865-007-9133-4 · Cited by 44

Clinical effects and pharmacokinetic variables of romifidine and the peripheral α2‐adrenoceptor antagonist MK‐467 in horses

de Vries, A., Pakkanen, S. A., Raekallio, M. R., Ekiri, A. B., Scheinin, M., Taylor, P. M., & Vainio, O. (2016) · Veterinary Anaesthesia and Analgesia · doi:10.1111/vaa.12354 · Cited by 43

Enteric alpha-2 adrenoceptors: Pathophysiological implications in functional and inflammatory bowel disorders

Blandizzi, C. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.05.013 · Cited by 45

Pharmacological and Pharmacokinetic Aspects of Functional Gastrointestinal Disorders

Camilleri, M., Bueno, L. P., Ponti, F. D., Fioramonti, J., Lydiard, R. B., & Tack, J. F. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.08.062 · Cited by 42

Barostat Measurement of Rectal Compliance and Capacity

Fox, M. R., Thumshirn, M., Fried, M., & Schwizer, W. (2006) · Diseases of the Colon & Rectum · doi:10.1007/s10350-005-0295-2 · Cited by 41

Meal induced rectosigmoid tone modification: a low caloric meal accurately separates functional and organic gastrointestinal disease patients

Stefano, M. D., Miceli, E., Missanelli, A., Mazzocchi, S., & Corazza, G. R. (2006) · Gut · doi:10.1136/gut.2005.076323 · Cited by 41

Drug Development for the Irritable Bowel Syndrome: Current Challenges and Future Perspectives

Ponti, F. D. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00007 · Cited by 40

Review article: drugs interfering with visceral sensitivity for the treatment of functional gastrointestinal disorders – the clinical evidence

Kuiken, S. D., Tytgat, G. N. J., & Boeckxstaens, G. E. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2005.02392.x · Cited by 40

The Antinociceptive Effects of Intravenous Dexmedetomidine in Colorectal Distension-Induced Visceral Pain in Rats: The Role of Opioid Receptors

Ülger, F., Bozkurt, A., Bilge, S. S., İlkaya, F., Dilek, A., Bostanci, M. Ö., Çıftçıoğlu, E., & Güldoğuş, F. (2009) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e3181a9fae2 · Cited by 38

Changes in brain G proteins and colonic sympathetic neural signaling in chronic-acute combined stress rat model of irritable bowel syndrome (IBS)

Zou, N., Lv, H., Li, J., Yang, N., Xue, H., Zhu, J., & Qian, J. (2008) · Translational research · doi:10.1016/j.trsl.2008.10.002 · Cited by 38

An exploratory study of the association of adrenergic and serotonergic genotype and gastrointestinal motor functions

Grudell, A., Camilleri, M., Carlson, P., Gorman, H., Ryks, M. D., Burton, D. D., Baxter, K. L., & Zinsmeister, A. R. (2007) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2007.01026.x · Cited by 36

Megacolon: Acute, toxic, and chronic

Bharucha, A. E., & Phillips, S. F. (1999) · Current Treatment Options in Gastroenterology · doi:10.1007/s11938-999-0055-9 · Cited by 35

Colonic Motor Function in Humans Is Not Affected by Gender

Soffer, E., Kongara, K. R., Achkar, J.-P., & Gannon, J. (2000) · Digestive Diseases and Sciences · doi:10.1023/a:1005535432163 · Cited by 35

Elevated expression of c-fos in central nervous system correlates with visceral hypersensitivity in irritable bowel syndrome (IBS): a new target for IBS treatment

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Lower gastrointestinal functions

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Effects of glucagon‐like peptide‐1 and sympathetic stimulation on gastric accommodation in humans1

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Potential biomarkers.

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Synchronized gastric electrical stimulation improves vagotomy-induced impairment in gastric accommodation via the nitrergic pathway in dogs

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Adrenoceptors and regulation of intestinal tone in the isolated colon of the mouse

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Oral clonidine inhibits visceral pain-related viscerosomatic and cardiovascular responses to colorectal distension in rats

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