The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Early NF-κB activation is associated with hormone-induced pancreatitis
Abstract
Inflammation and cell death are critical to pathogenesis of acute pancreatitis. Here we show that transcription factor nuclear factor-κB (NF-κB), which regulates these processes, is activated and plays a role in rat cerulein pancreatitis. NF-κB was strongly activated in the pancreas within 30 min of cerulein infusion; a second phase of NF-κB activation was prominent at 3–6 h. This biphasic kinetics could result from observed transient degradation of the inhibitory protein IκBα and slower but sustained degradation of IκBβ. The hormone also caused NF-κB translocation and IκB degradation in vitro in dispersed pancreatic acini. Both p65/p50 and p50/p50, but not c-Rel, NF-κB complexes were manifest in pancreatitis and in isolated acini. Coinfusion of CCK JMV-180, which abolishes pancreatitis, prevented cerulein-induced NF-κB activation. The second but not early phase of NF-κB activation was inhibited by a neutralizing tumor necrosis factor-α antibody. Antioxidant N-acetylcysteine (NAC) blocked NF-κB activation and significantly improved parameters of pancreatitis. In particular, NAC inhibited intrapancreatic trypsin activation and mRNA expression of cytokines interleukin-6 and KC, which were dramatically induced by cerulein. The results suggest that NF-κB activation is an important early event that may contribute to inflammatory and cell death responses in acute pancreatitis.
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Structure, Regulation and Function of NF-kappaB
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lnterleukin-8 and Related Chemotactic Cytokines—CXC and CC Chemokines
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Cited by
Activators and target genes of Rel/NF-κB transcription factors
Pahl, H. L. (1999) · Oncogene · doi:10.1038/sj.onc.1203239 · Cited by 3,727
Acute Pancreatitis: Bench to the Bedside
Pandol, S. J., Saluja, A. K., Imrie, C. W., & Banks, P. A. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.01.055 · Cited by 677
Self-citationPathophysiology of acute pancreatitis
Bhatia, M., Wong, F. L., Cao, Y., Lau, H. Y., Huang, J., Puneet, P., & Chevali, L. (2005) · Pancreatology · doi:10.1159/000085265 · Cited by 544
Autophagy, Inflammation, and Immune Dysfunction in the Pathogenesis of Pancreatitis
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Self-citationMacrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia through NF-κB and MMPs
Liou, G.-Y., Döppler, H., Necela, B., Krishna, M., Crawford, H. C., Raimondo, M., & Storz, P. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201301001 · Cited by 294
Metadata
- Authors
- Gukovsky, I., Gukovskaya, A. S., Blinman, T. A., Zaninovic, V., & Pandol, S. J.
- Venue
- American Journal of Physiology-Gastrointestinal and Liver Physiology
- Publisher
- American Physiological Society
- Published
- 1998-12-01
- Volume
- 275
- Issue
- 6
- Pages
- G1402-G1414
- ISSN
- 0193-1857 (ISSN-L)
- 1522-1547
- OpenAlex
- W2095940849
- Cited by
- 344
- References
- 43
- FWCI
- 9.62
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gukovsky, I., Gukovskaya, A. S., Blinman, T. A., Zaninovic, V., & Pandol, S. J. (1998). Early NF-κB activation is associated with hormone-induced pancreatitis. American Journal of Physiology-Gastrointestinal and Liver Physiology. https://doi.org/10.1152/ajpgi.1998.275.6.g1402
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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