The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Vagal afferent responses to fatty acids of different chain length in the rat
Abstract
The role of cholecystokinin (CCK) in the effect of dietary lipid on proximal gastrointestinal function and satiety is controversial. Recent work suggests that fatty acid chain length may be a determining factor. We investigated the mechanism by which long- and short-chain fatty acids activate jejunal afferent nerves in rats. Whole mesenteric afferent nerve discharge was recorded in anaesthetized male Wistar rats during luminal perfusion of saline, sodium oleate, and sodium butyrate (both 10 mM). Both fatty acids evoked characteristic afferent nerve responses, distinct from the mechanical response to saline, that were abolished in rats following chronic subdiaphragmatic vagotomy. The effect of oleate was abolished by the CCK-A receptor antagonist Devazepide (0.5 mg/kg), whereas the effect of butyrate persisted despite pretreatment with either Devazepide or a combination of the calcium channel inhibitors nifedipine (1 mg/kg) and the omega-conotoxins GVIA and SVIB (each 25 microg/kg). In summary, long- and short-chain fatty acids activate intestinal vagal afferents by different mechanisms; oleate acts via a CCK-mediated mechanism and butyrate appears to have a direct effect on afferent terminals.
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“SCFAs also activate vagal afferents in the gastrointestinal tract (364), transducing electric signals to modulate neurotransmitter levels in the brain and brain function.”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [364]
In the citing paper
“Vagal afferents express receptors that sense SCFAs55, and activation of this pathway has been implicated in glucose homeostasis56.”
From The gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease (2018) · cites this paper as [55]
Citations
Cites
Bioassay of plasma cholecystokinin in rats: Effects of food, trypsin inhibitor, and alcohol
Liddle, R. A., Goldfine, I. D., & Williams, J. A. (1984) · Gastroenterology · doi:10.1016/0016-5085(84)90524-9 · Cited by 410
Noble, F., Wank, S. A., Crawley, J. N., Bradwejn, J., Seroogy, K. B., Hamon, M., & Roques, B. P. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01427-3 · Cited by 385
A relation between the chain length of fatty acids and the slowing of gastric emptying
Hunt, J. N., & Knox, M. (1968) · The Journal of Physiology · doi:10.1113/jphysiol.1968.sp008411 · Cited by 301
Fatty acid chain length determines cholecystokinin secretion and effect on human gastric motility
McLaughlin, J. T., Lucà, M. G., Jones, M. N., D’Amato, M., Dockray, G. J., & Thompson, D. G. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70227-1 · Cited by 262
Self-citationEffects of cholecystokinin (CCK-8) on two classes of gastroduodenal vagal afferent fibre
Blackshaw, L. A., & Grundy, D. (1990) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(90)90185-l · Cited by 221
Self-citationBerthoud, H., Kressel, M., Raybould, H., & Neuhuber, W. (1995) · Anatomy and Embryology · doi:10.1007/bf00187819 · Cited by 216
Bertrand, P. P., Kunze, W., Bornstein, J. C., Furness, J. B., & Smith, M. (1997) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1997.273.2.g422 · Cited by 208
Cholecystokinin and Pancreozymin, one single Hormone?
Jorpes, E., & Mutt, V. (1966) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1966.tb03185.x · Cited by 196
Mechanism(s) of butyrate transport in Caco-2 cells: role of monocarboxylate transporter 1
Hadjiagapiou, C., Schmidt, L. N., Dudeja, P. K., Layden, T. J., & Ramaswamy, K. (2000) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2000.279.4.g775 · Cited by 182
I. CCK receptors: an exemplary family
Wank, S. A. (1998) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1998.274.4.g607 · Cited by 180
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(58638), Q. Z., Yuan, J., Wang, Z., Miao, J., Gong, H., & Han, Y. (2026) · Nutrients · doi:10.3390/nu18203311
Zhou, Y., Guan, Y., Sun, P., Zhang, J., Shentu, D., Rong, X., & Chen, Z. (2026) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-026-11268-4
Metadata
- Authors
- Lal, S., Kirkup, A. J., Brunsden, A. M., Thompson, D. G., & Grundy, D.
- Affiliations
- Salford Royal Hospital (GB)
- University of Sheffield (GB)
- Venue
- American Journal of Physiology-Gastrointestinal and Liver Physiology
- Publisher
- American Physiological Society
- Published
- 2001-10-01
- Volume
- 281
- Issue
- 4
- Pages
- G907-G915
- ISSN
- 0193-1857 (ISSN-L)
- 1522-1547
- OpenAlex
- W2256831100
- Cited by
- 303
- References
- 46
- Citations by year
- 2026: 11 · 2025: 22 · 2024: 22 · 2023: 29 · 2022: 24 · 2021: 23 · 2020: 20 · 2019: 13 · 2018: 18 · 2017: 4 · 2016: 8 · 2014: 13 · 2013: 7 · 2012: 8
- FWCI
- 3.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Gastrointestinal and Liver Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
- Keywords
- fatty acid chain length, vagal afferent nerves, cholecystokinin, sodium oleate, sodium butyrate, CCK-A receptor, devazepide, omega-conotoxin, nifedipine, subdiaphragmatic vagotomy, dietary fat
- MeSH terms
- Animals, Cholecystokinin, Electrophysiology, Hormone Antagonists, Jejunum, Male, Mesentery, Neurons, Afferent, Vagotomy, Vagus Nerve, Rats, Wistar, Oleic Acid, Devazepide, Butyric Acid, Rats
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