Cited by 303Regulation of Appetite and ObesityGastrointestinal motility and disordersBiochemical Analysis and Sensing Techniques

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Vagal afferent responses to fatty acids of different chain length in the rat

Lal, Simon, Kirkup, Anthony J., Brunsden, Alan M., Thompson, David G., Grundy, David·2001·American Journal of Physiology-Gastrointestinal and Liver Physiology

DOI 10.1152/ajpgi.2001.281.4.g907

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Abstract

The role of cholecystokinin (CCK) in the effect of dietary lipid on proximal gastrointestinal function and satiety is controversial. Recent work suggests that fatty acid chain length may be a determining factor. We investigated the mechanism by which long- and short-chain fatty acids activate jejunal afferent nerves in rats. Whole mesenteric afferent nerve discharge was recorded in anaesthetized male Wistar rats during luminal perfusion of saline, sodium oleate, and sodium butyrate (both 10 mM). Both fatty acids evoked characteristic afferent nerve responses, distinct from the mechanical response to saline, that were abolished in rats following chronic subdiaphragmatic vagotomy. The effect of oleate was abolished by the CCK-A receptor antagonist Devazepide (0.5 mg/kg), whereas the effect of butyrate persisted despite pretreatment with either Devazepide or a combination of the calcium channel inhibitors nifedipine (1 mg/kg) and the omega-conotoxins GVIA and SVIB (each 25 microg/kg). In summary, long- and short-chain fatty acids activate intestinal vagal afferents by different mechanisms; oleate acts via a CCK-mediated mechanism and butyrate appears to have a direct effect on afferent terminals.

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Authors: Lal, S., Kirkup, A. J., Brunsden, A. M., Thompson, D. G., & Grundy, D.
Affiliations: Salford Royal Hospital (GB)
University of Sheffield (GB)
ORCID: Lal, Simon
Thompson, David G.
Grundy, David
Venue: American Journal of Physiology-Gastrointestinal and Liver Physiology
Publisher: American Physiological Society
Published: 2001-10-01
Volume: 281
Issue: 4
Pages: G907-G915
ISSN: 0193-1857 (ISSN-L)
1522-1547
DOI: 10.1152/ajpgi.2001.281.4.g907
OpenAlex: W2256831100
Cited by: 303
References: 46
Citations by year: 2026: 11 · 2025: 22 · 2024: 22 · 2023: 29 · 2022: 24 · 2021: 23 · 2020: 20 · 2019: 13 · 2018: 18 · 2017: 4 · 2016: 8 · 2014: 13 · 2013: 7 · 2012: 8
FWCI: 3.32
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Gastrointestinal and Liver Physiology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
Keywords: fatty acid chain length, vagal afferent nerves, cholecystokinin, sodium oleate, sodium butyrate, CCK-A receptor, devazepide, omega-conotoxin, nifedipine, subdiaphragmatic vagotomy, dietary fat
MeSH terms: Animals, Cholecystokinin, Electrophysiology, Hormone Antagonists, Jejunum, Male, Mesentery, Neurons, Afferent, Vagotomy, Vagus Nerve, Rats, Wistar, Oleic Acid, Devazepide, Butyric Acid, Rats

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Vagal afferent responses to fatty acids of different chain length in the rat

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