A novel Toll-like receptor 4 antagonist antibody ameliorates inflammation but impairs mucosal healing in murine colitis
Open accessAbstract
Dysregulated innate immune responses to commensal bacteria contribute to the development of inflammatory bowel disease (IBD). TLR4 is overexpressed in the intestinal mucosa of IBD patients and may contribute to uncontrolled inflammation. However, TLR4 is also an important mediator of intestinal repair. The aim of this study is to examine the effect of a TLR4 antagonist on inflammation and intestinal repair in two murine models of IBD. Colitis was induced in C57BL/6J mice with dextran sodium sulfate (DSS) or by transferring CD45Rb(hi) T cells into RAG1-/- mice. An antibody (Ab) against the TLR4/MD-2 complex or isotype control Ab was administered intraperitoneally during DSS treatment, recovery from DSS colitis, or induction of colitis in RAG1-/- mice. Colitis severity was assessed by disease activity index (DAI) and histology. The effect of the Ab on the inflammatory infiltrate was determined by cell isolation and immunohistochemistry. Mucosal expression of inflammatory mediators was analyzed by real-time PCR and ELISA. Blocking TLR4 at the beginning of DSS administration delayed the development of colitis with significantly lower DAI scores. Anti-TLR4 Ab treatment decreased macrophage and dendritic cell infiltrate and reduced mucosal expression of CCL2, CCL20, TNF-alpha, and IL-6. Anti-TLR4 Ab treatment during recovery from DSS colitis resulted in defective mucosal healing with lower expression of COX-2, PGE(2), and amphiregulin. In contrast, TLR4 blockade had minimal efficacy in ameliorating inflammation in the adoptive transfer model of chronic colitis. Our findings suggest that anti-TLR4 therapy may decrease inflammation in IBD but may also interfere with colonic mucosal healing.
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Blocking TLR4 with antibodies limited acute inflammation in the DSS model but hampered subsequent tissue repair, suggesting an important role for TLR4 in the resolution of inflammation and restoration of tissue integrity.
“Although blocking TLR4 with antibodies limited acute inflammation in the DSS model, subsequent tissue repair was hampered, suggesting an important role for TLR4 in the resolution of inflammation and restoration of tissue integrity.162”
From Regulation of Intestinal Barrier Function by Microbial Metabolites (2021) · cites this paper as [162]
Cites
Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251 · see citing works
TLR4 links innate immunity and fatty acid-induced insulin resistance
Shi, H., Kokoeva, M. V., Inouye, K., Tzameli, I., Yin, H., & Flier, J. S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28898 · Cited by 3,690 · see citing works
Podolsky, D. K. (2002) · New England Journal of Medicine · doi:10.1056/nejmra020831 · Cited by 3,183 · see citing works
The gut flora as a forgotten organ
O'Hara, A. M., & Shanahan, F. (2006) · The EMBO Reports · doi:10.1038/sj.embor.7400731 · Cited by 2,791 · see citing works
Clinicopathologic study of dextran sulfate sodium experimental acute colitis
Shichijo, K., Matuu, M., Ikeda, Y., Naito, S., Ito, M., & Sekine, I. (1998) · The Japanese Journal of Pharmacology · doi:10.1016/s0021-5198(19)41298-5 · Cited by 1,943 · see citing works
Hornung, V., Rothenfußer, S., Britsch, S., Krug, A., Jahrsdörfer, B., Giese, T., Endres, S., & Hartmann, G. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.9.4531 · Cited by 1,927 · see citing works
MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways.
Medzhitov, R., Preston-Hurlburt, P., Kopp, E., Stadlen, A., Chen, C.-Q., Ghosh, S., & Janeway, C. (1998) · Molecules and Cells · doi:10.1016/s1097-2765(00)80136-7 · Cited by 1,783 · see citing works
Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4
Pålsson‐McDermott, E. M., & O'Neill, L. A. J. (2004) · Immunology · doi:10.1111/j.1365-2567.2004.01976.x · Cited by 1,254 · see citing works
Cario, E., & Podolsky, D. K. (2000) · Infection and Immunity · doi:10.1128/iai.68.12.7010-7017.2000 · Cited by 1,245 · see citing works
Dieleman, L. A., Palmen, M. J. H. J., Akol, H., Bloemena, E., Peña, A. S., Meuwissen, S. G. M., & van Rees, E. P. (1998) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1998.00728.x · Cited by 1,167 · see citing works
Duchmann, R., Kaiser, I., Hermann, E., Mayet, W.-J., Ewe, K., & BÜSCHENFELDE, K.-H. M. Z. (1995) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1995.tb03836.x · Cited by 938 · see citing works
Smythies, L. E., Sellers, M. T., Clements, R. H., Mosteller‐Barnum, M., Meng, G., Benjamin, W. H., Orenstein, J. M., & Smith, P. D. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200519229 · Cited by 924 · see citing works
Dendritic cells in intestinal immune regulation
Coombes, J. L., & Powrie, F. M. (2008) · Nature reviews. Immunology · doi:10.1038/nri2335 · Cited by 792 · see citing works
Role of Cytokines in the Pathogenesis of Inflammatory Bowel Disease
Papadakis, K. A., & Targan, S. R. (2000) · Annual Review of Medicine · doi:10.1146/annurev.med.51.1.289 · Cited by 714 · see citing works
Dextran sulfate sodium-induced colitis occurs in severe combined immunodeficient mice
Dieleman, L. A., Ridwan, B. U., Tennyson, G. S., Beagley, K. W., Bucy, R. P., & Elson, C. O. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90803-6 · Cited by 677 · see citing works
Toll-Like Receptor-4 Promotes the Development of Colitis-Associated Colorectal Tumors
Fukata, M., Chen, A., Vamadevan, A. S., Cohen, J., Breglio, K. J., Krishnareddy, S., Hsu, D. S., Xu, R., Harpaz, N., Dannenberg, A. J., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.09.008 · Cited by 623 · see citing works
Self-citationFranchimont, D. P., Vermeire, S., Housni, H. E., Pierik, M. J., Steen, K. V., Gustot, T., Quertinmont, E., Abramowicz, M., Gossum, A. V., Devière, J., et al. (2004) · Gut · doi:10.1136/gut.2003.030205 · Cited by 596 · see citing works
Fractalkine Preferentially Mediates Arrest and Migration of CD16+ Monocytes
Ancuța, P., Rao, R., Moses, A. V., Mehle, A., Shaw, S. K., Luscinskas, F. W., & Gabuzda, D. H. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20022156 · Cited by 566 · see citing works
Characteristics of Intestinal Dendritic Cells in Inflammatory Bowel Diseases
Hart, A. L., Al-Hassi, H. O., Rigby, R. J., Bell, S., Emmanuel, A. V., Knight, S. C., Kamm, M. A., & Stagg, A. J. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.05.013 · Cited by 562 · see citing works
Fukata, M., Michelsen, K. S., Eri, R. D., Thomas, L. S., Hu, B., Lukasek, K., Nast, C. C., Lechago, J., Xu, R., Naiki, Y., et al. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00328.2004 · Cited by 508 · see citing works
Self-citationToll-like receptors 2 and 4 are up-regulated during intestinal inflammation
Hausmann, M., Kießling, S., Mestermann, S., Webb, G. R., Spöttl, T., Andus, T., Schölmerich, J., Herfarth, H. H., Ray, K., Falk, W., et al. (2002) · Gastroenterology · doi:10.1053/gast.2002.33662 · Cited by 488 · see citing works
Elson, C. O., Cong, Y., McCracken, V. J., Dimmitt, R. A., Lorenz, R. G., & Weaver, C. T. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00291.x · Cited by 469 · see citing works
Fukata, M., Chen, A., Klepper, A. L., Krishnareddy, S., Vamadevan, A. S., Thomas, L. S., Xu, R., Inoue, H., Arditi, M., Dannenberg, A. J., et al. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.06.017 · Cited by 456 · see citing works
Self-citationMucosal antibodies in inflammatory bowel disease are directed against intestinal bacteria.
Macpherson, A. J., Khoo, U. Y., Forgács, I., Philpott‐Howard, J., & Bjarnason, I. (1996) · Gut · doi:10.1136/gut.38.3.365 · Cited by 435 · see citing works
Mahida, Y. R., Wu, K., & Jewell, D. P. (1989) · Gut · doi:10.1136/gut.30.6.835 · Cited by 427 · see citing works
Caron, G., Duluc, D., Frémaux, I., Jeannin, P., David, C., Gascan, H., & Delneste, Y. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.3.1551 · Cited by 410 · see citing works
Interferon-gamma is causatively involved in experimental inflammatory bowel disease in mice
Ito, R., Shin‐Ya, M., Kishida, T., Urano, A., Takada, R., Sakagami, J., Imanishi, J., Kita, M., Ueda, Y., Iwakura, Y., et al. (2006) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2006.03214.x · Cited by 365 · see citing works
Strategic Compartmentalization of Toll-Like Receptor 4 in the Mouse Gut
Ortega-Cava, C. F., Ishihara, S., Rumi, M. A. K., Kawashima, K., Ishimura, N., Kazumori, H., Udagawa, J., Kadowaki, Y., & Kinoshita, Y. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.8.3977 · Cited by 346 · see citing works
Aranda, R., Sydora, B. C., McAllister, P. L., Binder, S. W., Yang, H., Targan, S. R., & Kronenberg, M. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.7.3464 · Cited by 312 · see citing works
Furrie, E., Macfarlane, S., Thomson, G., Macfarlane, G. T., & Microbiology & Gut Biology Group, T. T. &. T. B. (2005) · Immunology · doi:10.1111/j.1365-2567.2005.02200.x · Cited by 282 · see citing works
Dieu‐Nosjean, M., Vicari, A. P., Lebecque, S., & Caux, C. (1999) · Journal of Leukocyte Biology · doi:10.1002/jlb.66.2.252 · Cited by 266 · see citing works
Rugtveit, J., Brandtzaeg, P., Halstensen, T. S., FAUSA, O., & Scott, H. (1994) · Gut · doi:10.1136/gut.35.5.669 · Cited by 266 · see citing works
The Immune Response in Inflammatory Bowel Disease
Brown, S. J., & Mayer, L. (2007) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01343.x · Cited by 237 · see citing works
Self-citationSuppression of experimental colitis by intestinal mononuclear phagocytes
Qualls, J. E., Kaplan, A. M., van Rooijen, N., & Cohen, D. A. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.1205734 · Cited by 237 · see citing works
Macrophage Migration Inhibitory Factor Induces Macrophage Recruitment via CC Chemokine Ligand 2
Gregory, J. L., Morand, E. F., McKeown, S. J., Ralph, J. A., Hall, P., Yang, Y. H., McColl, S. R., & Hickey, M. J. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.11.8072 · Cited by 229 · see citing works
Török, H., Glas, J., Tonenchi, L., Mussack, T., & Folwaczny, C. (2004) · Clinical Immunology · doi:10.1016/j.clim.2004.03.002 · Cited by 227 · see citing works
Fort, M. M., Mozaffarian, A., Stöver, A. G., Correia, J. D. S., Johnson, D. A., Crane, R. T., Ulevitch, R. J., Persing, D. H., Bielefeldt-Ohmann, H., Probst, P., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.10.6416 · Cited by 216 · see citing works
Shang, L., Fukata, M., Thirunarayanan, N., Martin, A. P., Arnaboldi, P. M., Maussang, D., Berin, M. C., Unkeless, J. C., Mayer, L., Abreu, M. T., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.04.020 · Cited by 203 · see citing works
Self-citationSzebeni, B., Veres, G., Dezsőfi, A., Rusai, K., Vannay, Á., Mráz, M., Majorová, E., & Arató, A. (2007) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2007.03531.x · Cited by 194 · see citing works
Adaptation of Bacteria to the Intestinal Niche: Probiotics and Gut Disorder
Dunne, C. P. (2001) · Inflammatory Bowel Diseases · doi:10.1097/00054725-200105000-00010 · Cited by 182 · see citing works
Frolová, L., Drastich, P., Rossmann, P., Kostovcikova, K., & Tlaskalová‐Hogenová, H. (2007) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.7a7303.2007 · Cited by 167 · see citing works
Pharmacological Inhibition of Endotoxin Responses Is Achieved by Targeting the TLR4 Coreceptor, MD-2
Visintin, A., Halmen, K. A., Latz, E., Monks, B. G., & Golenbock, D. T. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.10.6465 · Cited by 153 · see citing works
Khan, M. A., Ma, C., Knodler, L. A., Valdez, Y., Rosenberger, C. M., Deng, W., Finlay, B. B., & Vallance, B. A. (2006) · Infection and Immunity · doi:10.1128/iai.74.5.2522-2536.2006 · Cited by 147 · see citing works
Hans, W., Schölmerich, J., Groß, V., & Falk, W. (2000) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200012030-00002 · Cited by 145 · see citing works
The Role of Dendritic Cells in the Development of Acute Dextran Sulfate Sodium Colitis
Berndt, B. E., Zhang, M., Chen, G.-H., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.9.6255 · Cited by 140 · see citing works
Velde, A. A. T., van Kooyk, Y., Braat, H., et al. (2002) · European Journal of Immunology · doi:10.1002/immu.200390017 · Cited by 139 · see citing works
Baumgart, D. C., Metzke, D., Schmitz, J., Scheffold, A., Sturm, A., Wiedenmann, B. J., & Dignass, A. U. (2005) · Gut · doi:10.1136/gut.2004.040360 · Cited by 134 · see citing works
Role of Macrophage Inflammatory Protein-3α and Its Ligand CCR6 in Rheumatoid Arthritis
Ruth, J. H., Shahrara, S., Park, C. C., Morel, J., Kumar, P., Qin, S., & Koch, A. E. (2003) · Laboratory Investigation · doi:10.1097/01.lab.0000062854.30195.52 · Cited by 130 · see citing works
Fukata, M., Breglio, K. J., Chen, A., Vamadevan, A. S., Goo, T., Hsu, D. S., Conduah, D. E., Xu, R., & Abreu, M. T. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.3.1886 · Cited by 130 · see citing works
Self-citationAssociation Between Toll-like Receptor 4 and Inflammatory Bowel Disease
Oostenbrug, L. E., Drenth, J. P. H., de Jong, D. J., Nolte, I. M., Oosterom, E., van Dullemen, H. M., van der Linde, K., Meerman, G. J. T., van der Steege, G., Kleibeuker, J. H., et al. (2005) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000161305.81198.0f · Cited by 122 · see citing works
Peripheral monocyte and naive T-cell recruitment and activation in Crohn's disease
BURGIO, V. L., Fais, S., Boirivant, M., Perrone, A., & Pallone, F. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90560-x · Cited by 121 · see citing works
TLR4-induced IFN-γ production increases TLR2 sensitivity and drives Gram-negative sepsis in mice
Spiller, S., Elson, G., Ferstl, R., Dreher, S., Mueller, T., Freudenberg, M. A., Daubeuf, B., Wagner, H., & Kirschning, C. J. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20071990 · Cited by 115 · see citing works
Self-citationCutting Edge: T Cells Respond to Lipopolysaccharide Innately via TLR4 Signaling
Zanin‐Zhorov, A., Tal, G., Cahalon, L., Cohen-Sfady, M., Pevsner‐Fischer, M., Lider, O., & Cohen, I. R. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.1.41 · Cited by 114 · see citing works
Tokuyama, H., Ueha, S., Kurachi, M., Matsushima, K., Fuminori, M., Blumberg, R. S., & Kakimi, K. (2005) · International Immunology · doi:10.1093/intimm/dxh284 · Cited by 113 · see citing works
Use of antibiotics in the treatment of inflammatory bowel disease
Perencevich, M. L., & Burakoff, R. B. (2006) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000225330.38119.c7 · Cited by 111 · see citing works
Watanabe, N., Ikuta, K., Okazaki, K., Nakase, H., Tabata, Y., Matsuura, M., Tamaki, H., Kawanami, C., Honjo, T., & Chiba, T. (2003) · Digestive Diseases and Sciences · doi:10.1023/a:1021960401290 · Cited by 108 · see citing works
Fukuda, M., Kanauchi, O., Araki, Y., Andoh, A., Mitsuyama, K., Takagi, K., Toyonaga, A., Sata, M., Fujiyama, Y., Fukuoka, M., et al. (2002) · International Journal of Molecular Medicine · doi:10.3892/ijmm.9.1.65 · Cited by 103 · see citing works
Reduced intestinal inflammation induced by dextran sodium sulfate in interleukin-6-deficient mice
Naito, Y., Takagi, T., Uchiyama, K., Kuroda, M., Kokura, S., Ichikawa, H., Yanagisawa, R., Inoue, K.-I., Takano, H., Satoh, M., et al. (2004) · International Journal of Molecular Medicine · doi:10.3892/ijmm.14.2.191 · Cited by 92 · see citing works
Singh, J., Cruickshank, S. M., Newton, D. J., Wakenshaw, L., Graham, A. M., Lan, J., Lodge, J. P. A., Felsburg, P. J., & Carding, S. R. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00377.2004 · Cited by 80 · see citing works
Guo, J., Zhang, M., Wang, B., Yuan, Z., Guo, Z., Chen, T., Yu, Y., Qin, Z., & Cao, X. (2002) · International Journal of Cancer · doi:10.1002/ijc.10816 · Cited by 79 · see citing works
Innate and adaptive mechanisms to control of pathological intestinal inflammation
Kelsall, B. L. (2007) · The Journal of Pathology · doi:10.1002/path.2286 · Cited by 77 · see citing works
CD4+ T-cells in the regulation of inflammatory responses in the intestine
Powrie, F. M., Mauze, S., & Coffman, R. L. (1997) · Research in Immunology · doi:10.1016/s0923-2494(98)80152-1 · Cited by 73 · see citing works
Vučković, S., Florin, T. H., Khalil, D., et al. (2001) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2001.04686.x · Cited by 73 · see citing works
Adaptations of intestinal macrophages to an antigen-rich environment
Schenk, M., & Mueller, C. (2006) · Seminars in Immunology · doi:10.1016/j.smim.2006.09.002 · Cited by 70 · see citing works
Bennett‐Guerrero, E., Grocott, H. P., Levy, J. H., Stierer, K. A., Hogue, C. W. J., Cheung, A. T., Newman, M. F., Carter, A. A., Rossignol, D. P., & Collard, C. D. (2007) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000253501.07183.2a · Cited by 67 · see citing works
Macrophages in Inflammatory Bowel Disease
Grip, O., Janciauskiene, S. M., & Lindgren, S. C. (2003) · Current Drug Targets - Inflammation & Allergy · doi:10.2174/1568010033484179 · Cited by 60 · see citing works
Fractalkine induces chemotaxis and actin polymerization in human dendritic cells
Dichmann, S., Herouy, Y., Purlis, D., et al. (2001) · Inflammation Research · doi:10.1007/pl00000230 · Cited by 59 · see citing works
Allison, M. C., & Poulter, L. W. (1991) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1991.tb05757.x · Cited by 54 · see citing works
Wong, Y. N., Rossignol, D. P., Rose, J., Kao, R., Carter, A. R., & Lynn, M. (2003) · The Journal of Clinical Pharmacology · doi:10.1177/0091270003254804 · Cited by 54 · see citing works
Involvement of Dendritic Cells in the Pathogenesis of Inflammatory Bowel Disease
Leon, F., Smythies, L. E., Smith, P. D., et al. (2006) · Advances in experimental medicine and biology · doi:10.1007/0-387-33778-4_8 · Cited by 46 · see citing works
Hans, W., Schölmerich, J., Gross, V., & Falk, W. (2000) · PubMed · Cited by 46 · see citing works
Wang, L., Liu, Q., Sun, Q., et al. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.12.030 · Cited by 42 · see citing works
Furuta, T., Kikuchi, T., Akira, S., et al. (2006) · International Immunology · doi:10.1093/intimm/dxl099 · Cited by 42 · see citing works
Chemokines orchestrate leukocyte trafficking in inflammatory bowel disease
Zhong, W. (2007) · Frontiers in bioscience · doi:10.2741/2789 · Cited by 33 · see citing works
Advances in the pathogenesis of inflammatory bowel disease
Young, Y., & Abreu, M. T. (2006) · Current Gastroenterology Reports · doi:10.1007/s11894-006-0037-1 · Cited by 33 · see citing works
Self-citationCorrelation of dendritic cell infiltration with active crypt inflammation in ulcerative colitis
Watanabe, S., Yamakawa, M., Hiroaki, T., et al. (2006) · Clinical Immunology · doi:10.1016/j.clim.2006.10.013 · Cited by 30 · see citing works
Ohkawara, T., Takeda, H., Nishihira, J., et al. (2005) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2005.02877.x · Cited by 30 · see citing works
Dextran sulphate sodium induces acute colitis and alters hepatic function in hamsters
Karlsson, A., Jägervall, Å., Pettersson, M., Andersson, A., Gillberg, P., & Melgar, S. (2007) · International Immunopharmacology · doi:10.1016/j.intimp.2007.10.007 · Cited by 25 · see citing works
Strauch, U., Obermeier, F., Grunwald, N., et al. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i48.6529 · Cited by 22 · see citing works
Ohkawara, T., Takeda, H., Miyashita, K., et al. (2005) · Histochemistry and Cell Biology · doi:10.1007/s00418-005-0092-y · Cited by 20 · see citing works
Shirai, Y., Hashimoto, M., Kato, R., Kawamura, Y. I., Kirikae, T., Yano, H., Takashima, J., Kirihara, Y., Saitō, Y., Fujino, M., et al. (2004) · Journal of Clinical Immunology · doi:10.1023/b:joci.0000018062.01980.ba · Cited by 17 · see citing works
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- Authors
- Ungaro, R., Fukata, M., Hsu, D., Hernandez, Y., Breglio, K., Chen, A., Xu, R., Sotolongo, J., Espana, C., Zaias, J., Elson, G., Mayer, L., Kosco-Vilbois, M., & Abreu, M. T.
- Affiliations
- Mount Sinai Hospital (US)
- University of Miami (US)
- Icahn School of Medicine at Mount Sinai (US)
- Light Chain Bioscience (Switzerland) (CH)
- Venue
- American Journal of Physiology-Gastrointestinal and Liver Physiology
- Publisher
- American Physiological Society
- Published
- 2009-06
- Volume
- 296
- Issue
- 6
- Pages
- G1167-G1179
- ISSN
- 0193-1857 (ISSN-L)
- 1522-1547
- PMC
- PMC2697943
- OpenAlex
- W2121908572
- Cited by
- 159
- References
- 81
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 5 · 2023: 3 · 2022: 6 · 2021: 10 · 2020: 6 · 2019: 7 · 2018: 7 · 2017: 6 · 2016: 7 · 2015: 11 · 2014: 12 · 2013: 18 · 2012: 19
- FWCI
- 10.47
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Physiology-Gastrointestinal and Liver Physiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institute of Allergy and Infectious Diseases (AI-052266)
- National Institute of Diabetes and Digestive and Kidney Diseases (R21DK069594, DK069594)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Keywords
- TLR4, anti-TLR4 antibody, inflammatory bowel disease, colitis, mucosal healing, intestinal inflammation, MD-2, DSS-induced colitis, adoptive T cell therapy, macrophages, dendritic cells, MCP-1, CCL20, TNF-α, interleukin-6, cyclooxygenase-2, prostaglandin E2, amphiregulin
- MeSH terms
- Animals, Antibodies, Monoclonal, Antigen-Presenting Cells, Cell Movement, Colitis, Epithelial Cells, Female, Glycoproteins, Inflammation, Intestinal Mucosa, Lymph Nodes, Male, Mice, Inbred C57BL, Regeneration, T-Lymphocytes, Dinoprostone, Cytokines, Dextran Sulfate, Mice, Knockout, Homeodomain Proteins, Chemokines, Bacterial Translocation, Intercellular Signaling Peptides and Proteins, Cell Proliferation, Toll-Like Receptor 4, Mice, Cyclooxygenase 2, EGF Family of Proteins, Amphiregulin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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