Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function

Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis

Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251 · see citing works

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

Maslowski, K. M., Vieira, A. T., Ng, A., Kranich, J., Sierro, F., Yu, D., Schilter, H. C., Rolph, M. S., Mackay, F., Artis, D., et al. (2009) · Nature · doi:10.1038/nature08530 · Cited by 3,241 · see citing works

Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria

Rescigno, M., Urbano, M., Valzasina, B., Francolini, M., Rotta, G., Bonasio, R., Granucci, F., Kraehenbuhl, J.-P., & Ricciardi‐Castagnoli, P. (2001) · Nature Immunology · doi:10.1038/86373 · Cited by 2,554 · see citing works

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

Park, B., Song, D., Kim, H. M., Choi, B.-S., Lee, H., & Lee, J.-O. (2009) · Nature · doi:10.1038/nature07830 · Cited by 2,421 · see citing works

A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice

Okayasu, I., Hatakeyama, S., Yamada, M., Ohkusa, T., Inagaki, Y., & NAKAYA, R. (1990) · Gastroenterology · doi:10.1016/0016-5085(90)90290-h · Cited by 2,405 · see citing works

Molecular Analysis of Commensal Host-Microbial Relationships in the Intestine

Hooper, L. V., Wong, M. H., Thelin, A., Hansson, L., Falk, P. G., & Gordon, J. I. (2001) · Science · doi:10.1126/science.291.5505.881 · Cited by 2,202 · see citing works

MD-2, a Molecule that Confers Lipopolysaccharide Responsiveness on Toll-like Receptor 4

Shimazu, R., Akashi, S., Ogata, H., Nagai, Y., Fukudome, K., Miyake, K., & Kimoto, M. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.11.1777 · Cited by 2,187 · see citing works

APC mutations occur early during colorectal tumorigenesis

Powell, S. M., Zilz, N. D., Beazer-barclay, Y. D., Bryan, T. M., Hamilton, S. R., Thibodeau, S. N., Vogelstein, B., & Kinzler, K. W. (1992) · Nature · doi:10.1038/359235a0 · Cited by 1,925 · see citing works

Nod2-Dependent Regulation of Innate and Adaptive Immunity in the Intestinal Tract

Kobayashi, K. S., Chamaillard, M., Ogura, Y., Henegariu, O., Inohara, N., Núñez, G., & Flavell, R. A. (2005) · Science · doi:10.1126/science.1104911 · Cited by 1,776 · see citing works

CX 3 CR1-Mediated Dendritic Cell Access to the Intestinal Lumen and Bacterial Clearance

Niess, J. H., Brand, S., Gu, X., Landsman, L., Jung, S., McCormick, B. A., Vyas, J. M., Boes, M. L., Ploegh, H. L., Fox, J. G., et al. (2005) · Science · doi:10.1126/science.1102901 · Cited by 1,609 · see citing works

Multiple Intestinal Neoplasia Caused by a Mutation in the Murine Homolog of the APC Gene

Su, L.-K., Kinzler, K. W., Vogelstein, B., Preisinger, A. C., Moser, A. R., Luongo, C., Gould, K. A., & Dove, W. F. (1992) · Science · doi:10.1126/science.1350108 · Cited by 1,537 · see citing works

Symbiotic bacteria direct expression of an intestinal bactericidal lectin

Cash, H. L., Whitham, C. V., Behrendt, C. L., & Hooper, L. V. (2006) · Science · doi:10.1126/science.1127119 · Cited by 1,432 · see citing works

TLR9 signals after translocating from the ER to CpG DNA in the lysosome

Latz, E., Schoenemeyer, A., Visintin, A., Fitzgerald, K. A., Monks, B. G., Knetter, C. F., Lien, E., Nilsen, N. J., Espevik, T., & Golenbock, D. T. (2004) · Nature Immunology · doi:10.1038/ni1028 · Cited by 1,355 · see citing works

Cutting Edge: Bacterial Flagellin Activates Basolaterally Expressed TLR5 to Induce Epithelial Proinflammatory Gene Expression

Gewirtz, A. T., Navas, T. A., Lyons, S., Godowski, P. J., & Madara, J. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.4.1882 · Cited by 1,345 · see citing works

Severity of inflammation is a risk factor for colorectal neoplasia in ulcerative colitis

Rutter, M., Saunders, B., Wilkinson, K., Rumbles, S., Schofield, G., Kamm, M., Williams, C., Price, A., Talbot, I., & Forbes, A. (2004) · Gastroenterology · doi:10.1053/j.gastro.2003.11.010 · Cited by 1,255 · see citing works

Differential Alteration in Intestinal Epithelial Cell Expression of Toll-Like Receptor 3 (TLR3) and TLR4 in Inflammatory Bowel Disease

Cario, E., & Podolsky, D. K. (2000) · Infection and Immunity · doi:10.1128/iai.68.12.7010-7017.2000 · Cited by 1,245 · see citing works

Mammalian defensins in the antimicrobial immune response

Selsted, M. E., & Ouellette, A. J. (2005) · Nature Immunology · doi:10.1038/ni1206 · Cited by 1,196 · see citing works

Epithelial NEMO links innate immunity to chronic intestinal inflammation

Nenci, A., Becker, C., Wullaert, A., Gareus, R., Loo, G., Danese, S., Huth, M., Nikolaev, A., Neufert, C. F., Madison, B., et al. (2007) · Nature · doi:10.1038/nature05698 · Cited by 1,077 · see citing works

Secretion of microbicidal α-defensins by intestinal Paneth cells in response to bacteria

Ayabe, T., Satchell, D. P., Wilson, C. L., Parks, W. C., Selsted, M. E., & Ouellette, A. J. (2000) · Nature Immunology · doi:10.1038/77783 · Cited by 1,060 · see citing works

The immune geography of IgA induction and function

Macpherson, A. J., McCoy, K. D., Johansen, F.-E., & Brandtzaeg, P. (2007) · Mucosal Immunology · doi:10.1038/mi.2007.6 · Cited by 1,047 · see citing works

Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface

Vaishnava, S., Behrendt, C. L., Ismail, A. S., Eckmann, L., & Hooper, L. V. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808723105 · Cited by 1,019 · see citing works

Angiogenins: a new class of microbicidal proteins involved in innate immunity

Hooper, L. V., Stappenbeck, T. S., Hong, C. V., & Gordon, J. I. (2003) · Nature Immunology · doi:10.1038/ni888 · Cited by 929 · see citing works

Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis

Rachmilewitz, D., Katakura, K., Karmeli, F., Hayashi, T., Reinus, C., Rudensky, B., Akira, S., Takeda, K., Lee, J., Takabayashi, K., et al. (2004) · Gastroenterology · doi:10.1053/j.gastro.2003.11.019 · Cited by 859 · see citing works

Intestinal Bacteria Trigger T Cell-Independent Immunoglobulin A2 Class Switching by Inducing Epithelial-Cell Secretion of the Cytokine APRIL

He, B., Xu, W., Santini, P. A., Polydorides, A. D., Chiu, A., Estrella, J. S., Shan, M., Chadburn, A., Villanacci, V., Plebani, A., et al. (2007) · Immunity · doi:10.1016/j.immuni.2007.04.014 · Cited by 748 · see citing works

Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5

Uematsu, S., Fujimoto, K., Jang, M. H., Yang, B., Jung, Y.-J., Nishiyama, M., Sato, S., Tsujimura, T., Yamamoto, M., Yokota, Y., et al. (2008) · Nature Immunology · doi:10.1038/ni.1622 · Cited by 746 · see citing works

Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement

Chieppa, M., Rescigno, M., Huang, A. Y.-C., & Germain, R. N. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061884 · Cited by 711 · see citing works

An Agonist of Toll-Like Receptor 5 Has Radioprotective Activity in Mouse and Primate Models

Burdelya, L. G., Krivokrysenko, V. I., Tallant, T. C., Strom, E., Gleiberman, A. S., Gupta, D., Kurnasov, O. V., Fort, F. L., Osterman, A. L., DiDonato, J. A., et al. (2008) · Science · doi:10.1126/science.1154986 · Cited by 705 · see citing works

Impaired Defense of Intestinal Mucosa in Mice Lacking Intestinal Trefoil Factor

Mashimo, H. L., Wu, D., Podolsky, D. K., & Fishman, M. C. (1996) · Science · doi:10.1126/science.274.5285.262 · Cited by 702 · see citing works

Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function

Cario, E., Gerken, G., & Podolsky, D. K. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.02.056 · Cited by 697 · see citing works

Decreased Expression of Toll-Like Receptor-4 and MD-2 Correlates with Intestinal Epithelial Cell Protection Against Dysregulated Proinflammatory Gene Expression in Response to Bacterial Lipopolysaccharide

Abreu, M. T., Vora, P., Faure, E., Thomas, L. S., Arnold, E. T., & Arditi, M. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.3.1609 · Cited by 681 · see citing works

Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits

Brandl, K., Plitas, G., Mihu, C. N., Ubeda, C., Jia, T., Fleisher, M., Schnabl, B., DeMatteo, R. P., & Pamer, E. G. (2008) · Nature · doi:10.1038/nature07250 · Cited by 631 · see citing works

Toll-Like Receptor-4 Promotes the Development of Colitis-Associated Colorectal Tumors

Fukata, M., Chen, A., Vamadevan, A. S., Cohen, J., Breglio, K. J., Krishnareddy, S., Hsu, D. S., Xu, R., Harpaz, N., Dannenberg, A. J., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.09.008 · Cited by 623 · see citing works

Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells

Lee, J., Mo, J., Katakura, K., Alkalay, I., Rucker, A. N., Liu, Y., Lee, H., Shen, C., Cojocaru, G., Shenouda, S., et al. (2006) · Nature Cell Biology · doi:10.1038/ncb1500 · Cited by 621 · see citing works

SIGIRR, a negative regulator of Toll-like receptor–interleukin 1 receptor signaling

Wald, D. N., Qin, J., Zhao, Z., Qian, Y., Naramura, M., Tian, L., Towne, J. E., Sims, J. E., Stark, G. R., & Li, X. (2003) · Nature Immunology · doi:10.1038/ni968 · Cited by 606 · see citing works

Activated macrophages are an adaptive element of the colonic epithelial progenitor niche necessary for regenerative responses to injury

Pull, S. L., Doherty, J. M., Mills, J. C., Gordon, J. I., & Stappenbeck, T. S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405979102 · Cited by 605 · see citing works

Negative Regulation of Toll-like Receptor-mediated Signaling by Tollip

Zhang, G., & Ghosh, S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109537200 · Cited by 598 · see citing works

Colorectal cancer and genetic alterations in the Wnt pathway

Segditsas, S., & Tomlinson, I. (2006) · Oncogene · doi:10.1038/sj.onc.1210059 · Cited by 591 · see citing works

Regulation of Spontaneous Intestinal Tumorigenesis Through the Adaptor Protein MyD88

Rakoff-Nahoum, S., & Medzhitov, R. M. (2007) · Science · doi:10.1126/science.1140488 · Cited by 584 · see citing works

TLR Signaling in the Gut in Health and Disease

Abreu, M. T., Fukata, M., & Arditi, M. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.8.4453 · Cited by 577 · see citing works

Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor

Burns, K., Clatworthy, J., Martin, L., Martinon, F., Plumpton, C., Maschera, B., Lewis, A., Ray, K. P., Tschopp, J., & Volpe, F. (2000) · Nature Cell Biology · doi:10.1038/35014038 · Cited by 554 · see citing works

TACI and BAFF-R mediate isotype switching in B cells

Castigli, E., Wilson, S. A., Scott, S., Dedeoğlu, F., Xu, S., Lam, K., Bram, R. J., Jabara, H. H., & Geha, R. S. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20032000 · Cited by 544 · see citing works

Toll-Like Receptors on Tumor Cells Facilitate Evasion of Immune Surveillance

Huang, B., Zhao, J., Li, H., He, K., Chen, Y., Mayer, L. F., Unkeless, J. C., & Xiong, H. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0784 · Cited by 542 · see citing works

Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis

Fukata, M., Michelsen, K. S., Eri, R. D., Thomas, L. S., Hu, B., Lukasek, K., Nast, C. C., Lechago, J., Xu, R., Naiki, Y., et al. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00328.2004 · Cited by 508 · see citing works

Oral Probiotics Prevent Necrotizing Enterocolitis in Very Low Birth Weight Preterm Infants: A Multicenter, Randomized, Controlled Trial

Lin, H.-C., Hsu, C.-H., Chen, H.-L., Chung, M.-Y., Hsu, J.-F., Lien, R.-I., Tsao, L.-Y., Chen, C.-H., & Su, B.-H. (2008) · Pediatrics · doi:10.1542/peds.2007-3007 · Cited by 506 · see citing works

Mechanisms of cross hyporesponsiveness to toll-like receptor bacterial ligands in intestinal epithelial cells☆

Otte, J., Cario, E., & Podolsky, D. K. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.01.007 · Cited by 506 · see citing works

Innate and Adaptive Immunity Cooperate Flexibly to Maintain Host-Microbiota Mutualism

Slack, E. M. C., Hapfelmeier, S., Stecher, B., Velykoredko, Y., Stoel, M., Lawson, M. A., Geuking, M. B., Beutler, B., Tedder, T. F., Hardt, W., et al. (2009) · Science · doi:10.1126/science.1172747 · Cited by 503 · see citing works

Epithelial-cell-intrinsic IKK-β expression regulates intestinal immune homeostasis

Zaph, C., Troy, A. E., Taylor, B. C., Berman-Booty, L. D., Guild, K. J., Du, Y., Yost, E. A., Gruber, A. D., May, M. J., Greten, F. R., et al. (2007) · Nature · doi:10.1038/nature05590 · Cited by 496 · see citing works

At the Crossroads of Inflammation and Cancer

Clevers, H. C. (2004) · Cell · doi:10.1016/j.cell.2004.09.005 · Cited by 494 · see citing works

Influence of the normal flora on mucosal morphology and cellular renewal in the ileum. A comparison of germ-free and conventional mice.

Abrams, G. D., Bauer, H., & Sprinz, H. (1963) · PubMed · Cited by 482 · see citing works

A Critical Role for TLR4 in the Pathogenesis of Necrotizing Enterocolitis by Modulating Intestinal Injury and Repair

Leaphart, C. L., Cavallo, J. A., Gribar, S. C., Çetin, S., Li, J., Branca, M. F., Dubowski, T. D., Sodhi, C. P., & Hackam, D. J. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.7.4808 · Cited by 482 · see citing works

Toll-like receptor 2 enhances ZO-1-associated intestinal epithelial barrier integrity via protein kinase C

Cario, E., Gerken, G., & Podolsky, D. K. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.04.015 · Cited by 475 · see citing works

Postnatal acquisition of endotoxin tolerance in intestinal epithelial cells

Lotz, M., Gütle, D., Walther, S., Ménard, S., Bogdan, C., & Hornef, M. W. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20050625 · Cited by 464 · see citing works

Cox-2 Is Regulated by Toll-Like Receptor-4 (TLR4) Signaling: Role in Proliferation and Apoptosis in the Intestine

Fukata, M., Chen, A., Klepper, A. L., Krishnareddy, S., Vamadevan, A. S., Thomas, L. S., Xu, R., Inoue, H., Arditi, M., Dannenberg, A. J., et al. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.06.017 · Cited by 456 · see citing works

Toll-like receptor 9–induced type I IFN protects mice from experimental colitis

Katakura, K., Lee, J., Rachmilewitz, D., Li, G. C., Eckmann, L., & Raz, E. (2005) · Journal of Clinical Investigation · doi:10.1172/jci22996 · Cited by 450 · see citing works

Enterocyte TLR4 Mediates Phagocytosis and Translocation of Bacteria Across the Intestinal Barrier

Neal, M. D., Leaphart, C. L., Levy, R. M., Prince, J. M., Billiar, T. R., Watkins, S. C., Li, J., Çetin, S., Ford, H. R., Schreiber, A. D., et al. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.5.3070 · Cited by 434 · see citing works

Human Intestinal Epithelial Cells Are Broadly Unresponsive to Toll-Like Receptor 2-Dependent Bacterial Ligands: Implications for Host-Microbial Interactions in the Gut

Melmed, G., Thomas, L. S., Lee, N., Tesfay, S. Y., Lukasek, K., Michelsen, K. S., Zhou, Y., Hu, B., Arditi, M., & Abreu, M. T. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.3.1406 · Cited by 431 · see citing works

Impaired expression of peroxisome proliferator-activated receptor γ in ulcerative colitis

Dubuquoy, L., Jansson, E. Å., Deeb, S. S., Rakotobé, S., Karoui, M., Colombel, J., Auwerx, J. H., Pettersson, S., & Desreumaux, P. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00271-3 · Cited by 425 · see citing works

Trefoil peptides promote epithelial migration through a transforming growth factor beta-independent pathway.

Dignass, A. U., Lynch–Devaney, K., Kindon, H., Thim, L., & Podolsky, D. K. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117332 · Cited by 422 · see citing works

Deletion of TLR5 results in spontaneous colitis in mice

Vijay–Kumar, M., Sanders, C. J., Taylor, R. T., Kumar, A., Aitken, J. D., Sitaraman, S. V., Neish, A. S., Uematsu, S., Akira, S., Williams, I. R., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci33084 · Cited by 420 · see citing works

Current View: Intestinal Stem Cells and Signaling

Scoville, D. H., Sato, T., He, X., & Li, L. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.01.079 · Cited by 416 · see citing works

Toll-like Receptor 4 Resides in the Golgi Apparatus and Colocalizes with Internalized Lipopolysaccharide in Intestinal Epithelial Cells

Hornef, M. W., Frisan, T., Vandewalle, A., Normark, S. J., & Richter‐Dahlfors, A. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011788 · Cited by 413 · see citing works

The Roles of Bacteria and TLR4 in Rat and Murine Models of Necrotizing Enterocolitis

Jilling, T., Simon, D., Lu, J. N., Meng, F. J., Li, D., Schy, R., Thomson, R. B., Soliman, A., Arditi, M., & Caplan, M. S. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.5.3273 · Cited by 395 · see citing works

Toll-Like Receptor 4 Signaling by Intestinal Microbes Influences Susceptibility to Food Allergy

Bashir, M. E. H., Louie, S., Shi, H. N., & Nagler‐Anderson, C. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.11.6978 · Cited by 387 · see citing works

MyD88-mediated signals induce the bactericidal lectin RegIIIγ and protect mice against intestinal Listeria monocytogenes infection

Brandl, K., Plitas, G., Schnabl, B., DeMatteo, R. P., & Pamer, E. G. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070563 · Cited by 385 · see citing works

Immunostimulatory DNA ameliorates experimental and spontaneous murine colitis

Rachmilewitz, D., Karmeli, F., Takabayashi, K., Hayashi, T., Leider–Trejo, L., Lee, J., Leoni, L. M., & Raz, E. (2002) · Gastroenterology · doi:10.1053/gast.2002.32994 · Cited by 380 · see citing works

β-Defensin-2 Expression Is Regulated by TLR Signaling in Intestinal Epithelial Cells

Vora, P., Youdim, A., Thomas, L. S., Fukata, M., Tesfay, S., Lukasek, K., Michelsen, K. S., Wada, A., Hirayama, T., Arditi, M., et al. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.9.5398 · Cited by 358 · see citing works

TLR4 and MD-2 Expression Is Regulated by Immune-mediated Signals in Human Intestinal Epithelial Cells

Abreu, M. T., Arnold, E. T., Thomas, L. S., Gonsky, R., Zhou, Y., Hu, B., & Arditi, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110333200 · Cited by 356 · see citing works

Strategic Compartmentalization of Toll-Like Receptor 4 in the Mouse Gut

Ortega-Cava, C. F., Ishihara, S., Rumi, M. A. K., Kawashima, K., Ishimura, N., Kazumori, H., Udagawa, J., Kadowaki, Y., & Kinoshita, Y. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.8.3977 · Cited by 346 · see citing works

TSLP regulates intestinal immunity and inflammation in mouse models of helminth infection and colitis

Taylor, B. C., Zaph, C., Troy, A. E., Du, Y., Guild, K. J., Comeau, M. R., & Artis, D. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20081499 · Cited by 343 · see citing works

TLR9 Is Localized in the Endoplasmic Reticulum Prior to Stimulation

Leifer, C. A., Kennedy, M. N., Mazzoni, A., Lee, C., Kruhlak, M. J., & Segal, D. M. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.2.1179 · Cited by 342 · see citing works

Intracellular Recognition of Lipopolysaccharide by Toll-like Receptor 4 in Intestinal Epithelial Cells

Hornef, M. W., Normark, B. H., Vandewalle, A., & Normark, S. J. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20022194 · Cited by 330 · see citing works

The Toll–Interleukin-1 Receptor Member SIGIRR Regulates Colonic Epithelial Homeostasis, Inflammation, and Tumorigenesis

Xiao, H. Q., Gulen, M. F., Qin, J., Yao, J., Bulek, K., Kish, D. D., Altuntas, C. Z., Wald, D. N., Ma, C., Zhou, H., et al. (2007) · Immunity · doi:10.1016/j.immuni.2007.02.012 · Cited by 325 · see citing works

Commensal-Associated Molecular Patterns Induce Selective Toll-Like Receptor-Trafficking from Apical Membrane to Cytoplasmic Compartments in Polarized Intestinal Epithelium

Cario, E., Brown, D., McKee, M. L., Lynch–Devaney, K., Gerken, G., & Podolsky, D. K. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64360-x · Cited by 301 · see citing works

Commensal-dependent expression of IL-25 regulates the IL-23–IL-17 axis in the intestine

Zaph, C., Du, Y., Saenz, S. A., Nair, M. G., Perrigoue, J., Taylor, B. C., Troy, A. E., Kobuley, D. E., Kastelein, R. A., Cua, D. J., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080720 · Cited by 292 · see citing works

A two-step model for colon adenoma initiation and progression caused by APC loss

Phelps, R. A., Chidester, S., Dehghanizadeh, S., Phelps, J., Sandoval, I. T., Rai, K., Broadbent, T., Sarkar, S., Burt, R. W., & Jones, D. A. (2009) · Cell · doi:10.1016/j.cell.2009.02.037 · Cited by 286 · see citing works

Toll‐like receptors‐2, ‐3 and ‐4 expression patterns on human colon and their regulation by mucosal‐associated bacteria

Furrie, E., Macfarlane, S., Thomson, G., Macfarlane, G. T., & Microbiology & Gut Biology Group, T. T. &. T. B. (2005) · Immunology · doi:10.1111/j.1365-2567.2005.02200.x · Cited by 282 · see citing works

The gastrointestinal tract stem cell niche

Yen, T., & Wright, N. A. (2006) · Stem Cell Reviews and Reports · doi:10.1007/s12015-006-0048-1 · Cited by 279 · see citing works

Myd88-dependent positioning of Ptgs2-expressing stromal cells maintains colonic epithelial proliferation during injury

Brown, S. L., Riehl, T. E., Walker, M. R., Geske, M. J., Doherty, J. M., Stenson, W. F., & Stappenbeck, T. S. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29159 · Cited by 263 · see citing works

Taking toll: lipid A mimetics as adjuvants and immunomodulators

Persing, D. H., Coler, R. N., Lacy, M. J., Johnson, D. A., Baldridge, J. R., Hershberg, R. M., & Reed, S. G. (2002) · Trends in Microbiology · doi:10.1016/s0966-842x(02)02426-5 · Cited by 260 · see citing works

Reciprocal Expression and Signaling of TLR4 and TLR9 in the Pathogenesis and Treatment of Necrotizing Enterocolitis

Gribar, S. C., Sodhi, C. P., Richardson, W. M., Anand, R., Gittes, G. K., Branca, M. F., Jakub, A. M., Shi, X.-H., Shah, S. R., Ozolek, J. A., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.1.636 · Cited by 258 · see citing works

Intestinal inflammation in mice deficient in Tir8 , an inhibitory member of the IL-1 receptor family

Garlanda, C., Riva, F., Polentarutti, N., Buracchi, C., Sironi, M., Bortoli, M. D., Muzio, M., Bergottini, R., Scanziani, E., Vecchi, A., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308680101 · Cited by 254 · see citing works

MyD88-deficient mice develop severe intestinal inflammation in dextran sodium sulfate colitis

Araki, A., Kanai∥, T., Ishikura, T., Makita, S., Uraushihara, K., Iiyama, R., Totsuka, T., Takeda, K., Akira, S., & Watanabe, M. (2005) · Journal of Gastroenterology · doi:10.1007/s00535-004-1492-9 · Cited by 239 · see citing works

PU.1 and Interferon Consensus Sequence-binding Protein Regulate the Myeloid Expression of the Human Toll-like Receptor 4 Gene

Rehli, M., Poltorak, A., Schwarzfischer, L., Krause, S. W., Andreesen, R., & Beutler, B. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.13.9773 · Cited by 233 · see citing works

Colitis-Associated Variant of TLR2 Causes Impaired Mucosal Repair Because of TFF3 Deficiency

Podolsky, D. K., Gerken, G., Eyking, A., & Cario, E. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.03.007 · Cited by 231 · see citing works

Enteroendocrine cells express functional Toll-like receptors

Bogunovic, M., Davé, S. H., Tilstra, J. S., Chang, D. T. W., Harpaz, N., Xiong, H., Mayer, L. F., & Plevy, S. E. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00249.2006 · Cited by 230 · see citing works

Pathophysiological role of Toll-like receptor 5 engagement by bacterial flagellin in colonic inflammation

Rhee, S. H., Im, E., Riegler, M., Kokkotou, E., O'Brien, M., & Pothoulakis, C. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502174102 · Cited by 229 · see citing works

Epithelial cells prime the immune response to an array of gut‐derived commensals towards a tolerogenic phenotype through distinct actions of thymic stromal lymphopoietin and transforming growth factor‐β

Zeuthen, L. H., Fink, L. N., & Frokiaer, H. (2008) · Immunology · doi:10.1111/j.1365-2567.2007.02687.x · Cited by 227 · see citing works

Toll-Like Receptor-4 Inhibits Enterocyte Proliferation via Impaired β-Catenin Signaling in Necrotizing Enterocolitis

Sodhi, C. P., Shi, X.-H., Richardson, W. M., et al. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.09.045 · Cited by 221 · see citing works

Gamma Interferon Augments the Intracellular Pathway for Lipopolysaccharide (LPS) Recognition in Human Intestinal Epithelial Cells through Coordinated Up-Regulation of LPS Uptake and Expression of the Intracellular Toll-Like Receptor 4-MD-2 Complex

Suzuki, M., Hisamatsu, T., & Podolsky, D. K. (2003) · Infection and Immunity · doi:10.1128/iai.71.6.3503-3511.2003 · Cited by 217 · see citing works

A synthetic TLR4 antagonist has anti-inflammatory effects in two murine models of inflammatory bowel disease

Fort, M. M., Mozaffarian, A., Stöver, A. G., Correia, J. D. S., Johnson, D. A., Crane, R. T., Ulevitch, R. J., Persing, D. H., Bielefeldt-Ohmann, H., Probst, P., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.10.6416 · Cited by 216 · see citing works

Toll-Like Receptor Signaling in Small Intestinal Epithelium Promotes B-Cell Recruitment and IgA Production in Lamina Propria

Shang, L., Fukata, M., Thirunarayanan, N., Martin, A. P., Arnaboldi, P. M., Maussang, D., Berin, M. C., Unkeless, J. C., Mayer, L., Abreu, M. T., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.04.020 · Cited by 203 · see citing works

Flagellin Treatment Protects against Chemicals, Bacteria, Viruses, and Radiation

Vijay–Kumar, M., Aitken, J. D., Sanders, C. J., Frias, A. H., Sloane, V. M., Xu, J., Neish, A. S., Rojas, M., & Gewirtz, A. T. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.12.8280 · Cited by 201 · see citing works

The Gut Microbiota Predispose to the Pathophysiology of Acute Postradiotherapy Diarrhea

Manichanh, C., Varela, E., Martinez, C., Antolin, M., Llopis, M., Dor, J., Giralt, J., Guarner, F., & Malagelada, J.-R. (2008) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2008.01868.x · Cited by 201 · see citing works

Evidence for an Innate Immune Response in the Immature Human Intestine: Toll-Like Receptors on Fetal Enterocytes

Fusunyan, R. D., Nanthakumar, N. N., Baldeon, M. E., & Walker, W. A. (2001) · Pediatric Research · doi:10.1203/00006450-200104000-00023 · Cited by 201 · see citing works

In Vitro and ex Vivo Activation of the TLR5 Signaling Pathway in Intestinal Epithelial Cells by a Commensal Escherichia coli Strain

Bambou, J., Giraud, A., Ménard, S., Bègue, B., Rakotobé, S., Heyman, M., Taddéi, F., Cerf–Bensussan, N., & Gaboriau‐Routhiau, V. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405410200 · Cited by 195 · see citing works

MyD88 signalling plays a critical role in host defence by controlling pathogen burden and promoting epithelial cell homeostasis during Citrobacter rodentium-induced colitis

Gibson, D. L., Ma, C., Bergstrom, K., Huang, J. T., Man, C., & Vallance, B. A. (2007) · Cellular Microbiology · doi:10.1111/j.1462-5822.2007.01071.x · Cited by 195 · see citing works

Preoperative chemoradiation in fixed distal rectal cancer: dose time factors for pathological complete response

Mohiuddin, M., Regine, W. F., John, W. J., et al. (2000) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(99)00486-1 · Cited by 185 · see citing works

Toll-Like Receptor 5 Engagement Modulates Tumor Development and Growth in a Mouse Xenograft Model of Human Colon Cancer

Rhee, S. H., Im, E., & Pothoulakis, C. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.04.022 · Cited by 183 · see citing works

TLR Signaling Mediated by MyD88 Is Required for a Protective Innate Immune Response by Neutrophils to Citrobacter rodentium

Lebeis, S. L., Bommarius, B., Parkos, C. A., Sherman, M. A., & Kalman, D. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.1.566 · Cited by 176 · see citing works

Degranulation of paneth cells via toll-like receptor 9.

Rumio, C., Besusso, D., Palazzo, M., Selleri, S., Sfondrini, L., Dubini, F., Ménard, S., & Balsari, A. (2004) · American Journal of Pathology · doi:10.1016/s0002-9440(10)63304-4 · Cited by 175 · see citing works

Absence of Toll-Like Receptor 4 Explains Endotoxin Hyporesponsiveness in Human Intestinal Epithelium

Naik, S., Kelly, E. J., Meijer, L., Pettersson, S., & Sanderson, I. (2001) · Journal of Pediatric Gastroenterology and Nutrition - JPGN · doi:10.1097/00005176-200104000-00011 · Cited by 174 · see citing works

Toll-like receptor 2 plays a critical role in maintaining mucosal integrity during Citrobacter rodentium-induced colitis

Gibson, D. L., Ma, C., Rosenberger, C. M., Bergstrom, K., Valdez, Y., Huang, J. T., Khan, M. A., & Vallance, B. A. (2007) · Cellular Microbiology · doi:10.1111/j.1462-5822.2007.01052.x · Cited by 169 · see citing works

A novel Toll-like receptor 4 antagonist antibody ameliorates inflammation but impairs mucosal healing in murine colitis

Ungaro, R., Fukata, M., Hsu, D., Hernandez, Y., Breglio, K., Chen, A., Xu, R., Sotolongo, J., Espana, C., Zaias, J., et al. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90496.2008 · Cited by 159 · see citing works

Intestinal neoplasia in the ApcMin mouse: independence from the microbial and natural killer (beige locus) status.

Dove, W. F., Clipson, L. J., Gould, K. A., Luongo, C., Marshall, D. J., Moser, A. R., Newton, M. A., & Jacoby, R. F. (1997) · PubMed · Cited by 159 · see citing works

TLRs Regulate the Gatekeeping Functions of the Intestinal Follicle-Associated Epithelium

Chabot, S., Wagner, J. S., Farrant, S. A., & Neutra, M. R. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.7.4275 · Cited by 158 · see citing works

Innate immune signaling by Toll-like receptor-4 (TLR4) shapes the inflammatory microenvironment in colitis-associated tumors

Fukata, M., Hernandez, Y., Conduah, D. E., Cohen, J., Chen, A., Breglio, K. J., Goo, T., Hsu, D. S., Xu, R., & Abreu, M. T. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20880 · Cited by 157 · see citing works

Gut flora, Toll-like receptors and nuclear receptors: a tripartite communication that tunes innate immunity in large intestine

Lundin, A., Bok, C. M., Aronsson, L., Björkholm, B., Gustafsson, J.-Å., Pott, S., Arulampalam, V., Hibberd, M. L., Rafter, J. J., & Pettersson, S. (2008) · Cellular Microbiology · doi:10.1111/j.1462-5822.2007.01108.x · Cited by 153 · see citing works

Bacterial DNA evokes epithelial IL‐8 production by a MAPK‐dependent, NFκB‐independent pathway

Akhtar, M., Watson, J. L., Nazli, A., & McKay, D. M. (2003) · The FASEB Journal · doi:10.1096/fj.02-0950fje · Cited by 153 · see citing works

Activation of Enteroendocrine Cells via TLRs Induces Hormone, Chemokine, and Defensin Secretion

Palazzo, M., Balsari, A., Rossini, A., Selleri, S., Calcaterra, C., Gariboldi, S., Zanobbio, L., Arnaboldi, F., Shirai, Y. F., Serrao, G., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.7.4296 · Cited by 147 · see citing works

Toll-Like Receptor 4 Contributes to Colitis Development but Not to Host Defense during Citrobacter rodentium Infection in Mice

Khan, M. A., Ma, C., Knodler, L. A., Valdez, Y., Rosenberger, C. M., Deng, W., Finlay, B. B., & Vallance, B. A. (2006) · Infection and Immunity · doi:10.1128/iai.74.5.2522-2536.2006 · Cited by 147 · see citing works

Surface Expression of Toll-Like Receptor 9 Is Upregulated on Intestinal Epithelial Cells in Response to Pathogenic Bacterial DNA

Ewaschuk, J. B., Backer, J., Churchill, T. A., Obermeier, F., Krause, D. O., & Madsen, K. L. (2007) · Infection and Immunity · doi:10.1128/iai.01662-06 · Cited by 147 · see citing works

Enterocyte-Derived TAK1 Signaling Prevents Epithelium Apoptosis and the Development of Ileitis and Colitis

Kajino‐Sakamoto, R., Inagaki, M., Lippert, E., Akira, S., Robine, S., Matsumoto, K., Jobin, C., & Ninomiya‐Tsuji, J. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.2.1143 · Cited by 147 · see citing works

Activation of toll-like receptor 3 protects against DSS-induced acute colitis

Vijay–Kumar, M., Wu, H., Aitken, J., Kolachala, V. L., Neish, A. S., Sitaraman, S. V., & Gewirtz, A. T. (2007) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20142 · Cited by 138 · see citing works

Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways

Zeng, H., Wu, H., Sloane, V. M., et al. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00273.2005 · Cited by 136 · see citing works

Expression of Toll-like receptor 9 and response to bacterial CpG oligodeoxynucleotides in human intestinal epithelium

Pedersen, G., Andresen, L. O., Matthiessen, M. W., Rask-Madsen, J., & Brynskov, J. (2005) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2005.02848.x · Cited by 134 · see citing works

Regulation of Serum Amyloid A3 (SAA3) in Mouse Colonic Epithelium and Adipose Tissue by the Intestinal Microbiota

Reigstad, C. S., Östergren‐Lundén, G., Felin, J., & Bäckhed, F. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005842 · Cited by 131 · see citing works

Lipopolysaccharide is radioprotective in the mouse intestine through a prostaglandin-mediated mechanism

Riehl, T. E., Cohn, S. M., Tessner, T. G., Schloemann, S. R., & Stenson, W. F. (2000) · Gastroenterology · doi:10.1016/s0016-5085(00)70363-5 · Cited by 124 · see citing works

Increased Susceptibility to Colitis-Associated Cancer of Mice Lacking TIR8 , an Inhibitory Member of the Interleukin-1 Receptor Family

Garlanda, C., Riva, F., Veliz, T., Polentarutti, N., Pasqualini, F., Radaelli, E., Sironi, M., Nebuloni, M., Zorini, E. O., Scanziani, E., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0560 · Cited by 123 · see citing works

Flagellin Suppresses Epithelial Apoptosis and Limits Disease during Enteric Infection

Vijay–Kumar, M., Wu, H., Jones, R. M., Grant, G., Babbin, B. A., King, T. P., Kelly, D., Gewirtz, A. T., & Neish, A. S. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.060345 · Cited by 122 · see citing works

Regulation of Colonic Epithelial Repair in Mice by Toll-Like Receptors and Hyaluronic Acid

Zheng, L., Riehl, T. E., & Stenson, W. F. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.08.055 · Cited by 118 · see citing works

IL-10 Gene-Deficient Mice Lack TGF-β/Smad Signaling and Fail to Inhibit Proinflammatory Gene Expression in Intestinal Epithelial Cells after the Colonization with Colitogenic Enterococcus faecalis

Ruiz, P. A., Shkoda, A., Kim, S. C., Sartor, R. B., & Haller, D. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.5.2990 · Cited by 116 · see citing works

Recognition of Double-Stranded RNA by TLR3 Induces Severe Small Intestinal Injury in Mice

Zhou, R., Wei, H., Sun, R., & Tian, Z. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.7.4548 · Cited by 107 · see citing works

TLR signaling at the intestinal epithelial interface

Abreu, M. T., Thomas, L. S., Arnold, E. T., Lukasek, K., Michelsen, K. S., & Arditi, M. (2003) · Journal of Endotoxin Research · doi:10.1179/096805103225002593 · Cited by 107 · see citing works

Toll-like receptor 2 is critical for induction of Reg3β expression and intestinal clearance of Yersinia pseudotuberculosis

Dessein, R., Gironella, M., Vignal, C., Peyrin‐Biroulet, L., Sokol, H., Sécher, T., Lacas‐Gervais, S., Gratadoux, J.-J., Lafont, F., Dagorn, J.-C., et al. (2009) · Gut · doi:10.1136/gut.2008.168443 · Cited by 106 · see citing works

Th2 Cytokines Down-Regulate TLR Expression and Function in Human Intestinal Epithelial Cells

Mueller, T., Terada, T., Rosenberg, I. M., Shibolet, O., & Podolsky, D. K. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.10.5805 · Cited by 103 · see citing works

Review: Enteroendocrine cells: Neglected players in gastrointestinal disorders?

Moran, G. W., Leslie, F. C., Levison, S., & McLaughlin, J. T. (2008) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x08093943 · Cited by 102 · see citing works

Changes in intestinal Toll-like receptors and cytokines precede histological injury in a rat model of necrotizing enterocolitis

Liu, Y., Zhu, L., Fatheree, N. Y., Liu, X., Pacheco, S. E., Tatevian, N., & Rhoads, J. M. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00182.2009 · Cited by 98 · see citing works

Microbial Pattern Recognition Receptors Mediate M-Cell Uptake of a Gram-Negative Bacterium

Tyrer, P. C., Foxwell, A. R., Cripps, A. W., Apicella, M. A., & Kyd, J. M. (2005) · Infection and Immunity · doi:10.1128/iai.74.1.625-631.2006 · Cited by 97 · see citing works

TLR5-Mediated Phosphoinositide 3-Kinase Activation Negatively Regulates Flagellin-Induced Proinflammatory Gene Expression

Yu, Y., Nagai, S., Wu, H., Neish, A. S., Koyasu, S., & Gewirtz, A. T. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.10.6194 · Cited by 87 · see citing works

Regulation of Toll-like receptor 4-associated MD-2 in intestinal epithelial cells: a comprehensive analysis

Vamadevan, A. S., Fukata, M., Arnold, E. T., Thomas, L. S., Hsu, D. S., & Abreu, M. T. (2009) · Innate Immunity · doi:10.1177/1753425909339231 · Cited by 86 · see citing works

Role of Shiga toxin versus H7 flagellin in enterohaemorrhagic Escherichia coli signalling of human colon epithelium in vivo

Miyamoto, Y., Iimura, M., Kaper, J. B., et al. (2006) · Cellular Microbiology · doi:10.1111/j.1462-5822.2005.00673.x · Cited by 85 · see citing works

Time-course expression of Toll-like receptors 2 and 4 in inflammatory bowel disease and homeostatic effect of VIP

Gomariz, R. P., Arranz, A., Abad, C., Torroba, M., Martínez, C., Rosignoli, F., García-Gómez, M., Leceta, J., & Juarranz, Y. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.1004564 · Cited by 85 · see citing works

Toll-like receptor-mediated responses of primary intestinal epithelial cells during the development of colitis

Singh, J., Cruickshank, S. M., Newton, D. J., Wakenshaw, L., Graham, A. M., Lan, J., Lodge, J. P. A., Felsburg, P. J., & Carding, S. R. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00377.2004 · Cited by 80 · see citing works

Regulatory molecules required for nucleotide‐sensing Toll‐like receptors

Saitoh, S.-I., & Miyake, K. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00729.x · Cited by 79 · see citing works

Expression of TLR-2, TLR-4, NOD2 and pNF-κB in a Neonatal Rat Model of Necrotizing Enterocolitis

Schultz, A. L. M., Bonnard, A., Barreau, F., Aigrain, Y. Y., Pierre-Louis, C., Berrebi, D. D., & Peuchmaur, M. M. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001102 · Cited by 79 · see citing works

Modulation of dendritic cell phenotype and functionin an in vitro model of the intestinal epithelium

Butler, M., Ng, C., van Heel, D. A., Lombardi, G., Lechler, R. I., Playford, R. J., & Ghosh, S. K. (2006) · European Journal of Immunology · doi:10.1002/eji.200535497 · Cited by 75 · see citing works

IL-27 Regulates Homeostasis of the Intestinal CD4+ Effector T Cell Pool and Limits Intestinal Inflammation in a Murine Model of Colitis

Troy, A. E., Zaph, C., Du, Y., Taylor, B. C., Guild, K. J., Hunter, C. A., Saris, C. J. M., & Artis, D. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802918 · Cited by 72 · see citing works

Does necrotising enterocolitis impact the neurodevelopmental and growth outcomes in preterm infants with birthweight ≤1250 g?

Soraisham, A. S., Amin, H. J., Al-Hindi, M. Y., et al. (2006) · Journal of Paediatrics and Child Health · doi:10.1111/j.1440-1754.2006.00910.x · Cited by 70 · see citing works

Refolding, purification, and characterization of human and murine RegIII proteins expressed in Escherichia coli

Cash, H. L., Whitham, C. V., & Hooper, L. V. (2006) · Protein Expression and Purification · doi:10.1016/j.pep.2006.01.014 · Cited by 65 · see citing works

Human CD8+ intraepithelial lymphocytes: a unique model to study the regulation of effector cytotoxic T lymphocytes in tissue

Jabrì, B., & Ebert, E. C. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2006.00481.x · Cited by 57 · see citing works

Rapamycin suppresses TLR4-triggered IL-6 and PGE2 production of colon cancer cells by inhibiting TLR4 expression and NF-κB activation

Sun, Q., Liu, Q., Zheng, Y., & Cao, X. (2008) · Molecular Immunology · doi:10.1016/j.molimm.2008.01.025 · Cited by 55 · see citing works

Mouse Paneth Cell Secretory Responses to Cell Surface Glycolipids of Virulent and Attenuated Pathogenic Bacteria

Tanabe, H., Ayabe, T., Bainbridge, B. W., Guina, T., Ernst, R. K., Darveau, R. P., Miller, S. I., & Ouellette, A. J. (2005) · Infection and Immunity · doi:10.1128/iai.73.4.2312-2320.2005 · Cited by 55 · see citing works

Necrotizing enterocolitis — bench to bedside: novel and emerging strategies

Guner, Y. S., Chokshi, N. K., Petrosyan, M., Upperman, J. S., Ford, H. R., & Grikscheit, T. C. (2008) · Seminars in Pediatric Surgery · doi:10.1053/j.sempedsurg.2008.07.004 · Cited by 54 · see citing works

Expression and function of toll-like receptor 8 and Tollip in colonic epithelial cells from patients with inflammatory bowel disease

Steenholdt, C., Andresen, L. O., Pedersen, G., Hansen, A., & Brynskov, J. (2008) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520802495529 · Cited by 54 · see citing works

Both Radioresistant and Hemopoietic Cells Promote Innate and Adaptive Immune Responses to Flagellin

Sanders, C. J., Moore, D. A., Williams, I. R., & Gewirtz, A. T. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.11.7184 · Cited by 53 · see citing works

Signal Integration Following Toll-like Receptor Triggering

Dalpke, A. H., & Heeg, K. M. (2002) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.v22.i3.40 · Cited by 52 · see citing works

Trypsin-Sensitive Modulation of Intestinal Epithelial MD-2 as Mechanism of Lipopolysaccharide Tolerance

Cario, E., Golenbock, D. T., Visintin, A., Rünzi, M., Gerken, G., & Podolsky, D. K. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.7.4258 · Cited by 49 · see citing works

MD-2 controls bacterial lipopolysaccharide hyporesponsiveness in human intestinal epithelial cells

Lenoir, C., Sapin, C., Broquet, A. H., et al. (2007) · Life Sciences · doi:10.1016/j.lfs.2007.12.007 · Cited by 47 · see citing works

Inflammatory Bowel Disease: A Model of Chronic Inflammation-Induced Cancer

Yang, G., Taboada, S., & Liao, J. (2009) · Methods in molecular biology · doi:10.1007/978-1-59745-447-6_9 · Cited by 46 · see citing works

Immunostimulatory Oligonucleotides Inhibit Colonic Proinflammatory Cytokine Production in Ulcerative Colitis

Rachmilewitz, D., Karmeli, F., Shteingart, S., et al. (2006) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000217335.30689.77 · Cited by 44 · see citing works

TNFR1 mediates the radioprotective effects of lipopolysaccharide in the mouse intestine

Riehl, T. E., Newberry, R. D., Lorenz, R. G., & Stenson, W. F. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00537.2002 · Cited by 43 · see citing works

Regulation of toll‐like receptors in intestinal epithelial cells by stress and Toxoplasma gondii infection

Gopal, R., Birdsell, D. N., & Monroy, F. P. (2008) · Parasite Immunology · doi:10.1111/j.1365-3024.2008.01055.x · Cited by 42 · see citing works

Cytokine‐mediated control of lipopolysaccharide‐induced activation of small intestinal epithelial cells

Lotz, M., König, T., Ménard, S., Gütle, D., Bogdan, C., & Hornef, M. W. (2007) · Immunology · doi:10.1111/j.1365-2567.2007.02639.x · Cited by 34 · see citing works

X. Trefoil peptide and EGF receptor/ligand transgenic mice

Giraud, A. S. (2000) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2000.278.4.g501 · Cited by 32 · see citing works

Age-related increase of porcine natural interferon α producing cell frequency and of interferon yield per cell

Nowacki, W., CEDERBLAD, B., Renard, C., et al. (1993) · Veterinary Immunology and Immunopathology · doi:10.1016/0165-2427(93)90059-d · Cited by 31 · see citing works

Intestinal Epithelial-Derived TAK1 Signaling Is Essential for Cytoprotection against Chemical-Induced Colitis

Kim, J., Kajino‐Sakamoto, R., Omori, E., Jobin, C., & Ninomiya‐Tsuji, J. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004561 · Cited by 28 · see citing works

Regulation of Toll-like receptor 4 expression in mouse colon by macrophage migration inhibitory factor

Ohkawara, T., Takeda, H., Miyashita, K., et al. (2005) · Histochemistry and Cell Biology · doi:10.1007/s00418-005-0092-y · Cited by 20 · see citing works

Comparison of late rectal toxicity from conventional versus three-dimensional conformal radiotherapy for prostate cancer: Analysis of clinical and dosimetric factors

Lee, C. M., Lee, R. J., Handrahan, D. L., et al. (2005) · Urology · doi:10.1016/j.urology.2004.08.037 · Cited by 15 · see citing works

A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice

Plovier, H., Everard, A., Druart, C., Depommier, C., Van Hul, M., Geurts, L., Chilloux, J., Ottman, N., Duparc, T., Lichtenstein, L., et al. (2017) · Nature Medicine · doi:10.1038/nm.4236 · Cited by 2,204 · see citing works

Control of adaptive immunity by the innate immune system

Iwasaki, A., & Medzhitov, R. (2015) · Nature Immunology · doi:10.1038/ni.3123 · Cited by 2,160 · see citing works

The gut-liver axis and the intersection with the microbiome

Tripathi, A., Debelius, J., Brenner, D. A., Karin, M., Loomba, R., Schnabl, B., & Knight, R. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0011-z · Cited by 1,480 · see citing works

Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders

Kelly, J. R., Kennedy, P. J., Cryan, J. F., Dinan, T. G., Clarke, G., & Hyland, N. P. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00392 · Cited by 1,110 · see citing works

Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4

Venkatesh, M., Mukherjee, S., Wang, H., Li, H., Sun, K., Benechet, A. P., Qiu, Z., Maher, L., Redinbo, M. R., Phillips, R. S., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.014 · Cited by 1,066 · see citing works

The intestinal epithelium: central coordinator of mucosal immunity

Allaire, J. M., Crowley, S. M., Law, H. T., Chang, S.-Y., Ko, H.-J., & Vallance, B. A. (2018) · Trends in Immunology · doi:10.1016/j.it.2018.04.002 · Cited by 933 · see citing works

Gut Microbial Metabolites Fuel Host Antibody Responses

Kim, M., Qie, Y., Park, J., & Kim, C. H. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.07.001 · Cited by 893 · see citing works

Shifting the balance: antibiotic effects on host–microbiota mutualism

Willing, B. P., Russell, S. L., & Finlay, B. B. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2536 · Cited by 747 · see citing works

Homeostasis in intestinal epithelium is orchestrated by the circadian clock and microbiota cues transduced by TLRs

Mukherji, A., Kobiita, A., Ye, T., & Chambon, P. (2013) · Cell · doi:10.1016/j.cell.2013.04.020 · Cited by 560 · see citing works

TLR5-mediated sensing of gut microbiota is necessary for antibody responses to seasonal influenza vaccination

Oh, J. Z., Ravindran, R., Chassaing, B., Carvalho, F. A., Maddur, M. S., Bower, M., Hakimpour, P., Gill, K. P., Nakaya, H. I., Yarovinsky, F., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.08.009 · Cited by 541 · see citing works

Microbial Translocation Across the GI Tract

Brenchley, J. M., & Douek, D. C. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075001 · Cited by 496 · see citing works

Autism Spectrum Disorders and the Gut Microbiota

Fattorusso, A., Di Genova, L., Dell’Isola, G., Mencaroni, E., & Esposito, S. (2019) · Nutrients · doi:10.3390/nu11030521 · Cited by 484 · see citing works

The role of inflammation and the gut microbiome in depression and anxiety

Peirce, J. M., & Alviña, K. (2019) · Journal of Neuroscience Research · doi:10.1002/jnr.24476 · Cited by 466 · see citing works

IL-17C regulates the innate immune function of epithelial cells in an autocrine manner

Ramirez-Carrozzi, V., Sambandam, A., Luis, E., Lin, Z., Jeet, S., Lesch, J., Hackney, J., Kim, J., Zhou, M., Lai, J., et al. (2011) · Nature Immunology · doi:10.1038/ni.2156 · Cited by 477 · see citing works

The Gut Microbiota and Autism Spectrum Disorders

Li, Q., Han, Y., Dy, A. B. C., & Hagerman, R. J. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00120 · Cited by 462 · see citing works

Neuropeptides and the Microbiota-Gut-Brain Axis

Holzer, P., & Farzi, A. (2014) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4939-0897-4_9 · Cited by 451 · see citing works

A Map of Toll-like Receptor Expression in the Intestinal Epithelium Reveals Distinct Spatial, Cell Type-Specific, and Temporal Patterns

Price, A. E., Shamardani, K., Lugo, K. A., Deguine, J., Roberts, A. W., Lee, B. L., & Barton, G. M. (2018) · Immunity · doi:10.1016/j.immuni.2018.07.016 · Cited by 379 · see citing works

Central Nervous System Demyelinating Disease Protection by the Human Commensal <i>Bacteroides fragilis</i> Depends on Polysaccharide A Expression

Ochoa-Repáraz, J., Mielcarz, D. W., Ditrio, L. E., Burroughs, A. R., Begum-Haque, S., Dasgupta, S., Kasper, D. L., & Kasper, L. H. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001443 · Cited by 367 · see citing works

Leaky Gut and Autoimmune Diseases

Fasano, A. (2012) · Clinical Reviews in Allergy &amp; Immunology · doi:10.1007/s12016-011-8291-x · Cited by 342 · see citing works

Gut microbiota role in irritable bowel syndrome: New therapeutic strategies

Distrutti, E., Monaldi, L., Ricci, P., & Fiorucci, S. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i7.2219 · Cited by 320 · see citing works

Nutritional iron turned inside out: intestinal stress from a gut microbial perspective

Kortman, G. A. M., Raffatellu, M., Swinkels, D. W., & Tjalsma, H. (2014) · FEMS Microbiology Reviews · doi:10.1111/1574-6976.12086 · Cited by 291 · see citing works

The role of gut dysbiosis in Parkinson’s disease: mechanistic insights and therapeutic options

Wang, Q., Luo, Y., Ray Chaudhuri, K., Reynolds, R., Tan, E.-K., & Pettersson, S. (2021) · Brain · doi:10.1093/brain/awab156 · Cited by 281 · see citing works

Gut microbiota modulate T cell trafficking into human colorectal cancer

Cremonesi, E., Governa, V., Garzon, J. F. G., Mele, V., Amicarella, F., Muraro, M. G., Trella, E., Galati-Fournier, V., Oertli, D., Däster, S. R., et al. (2018) · Gut · doi:10.1136/gutjnl-2016-313498 · Cited by 275 · see citing works

Germ-free and antibiotic-treated mice are highly susceptible to epithelial injury in DSS colitis

Hernández-Chirlaque, C., Aranda, C. J., Ocón, B., Capitán-Cañadas, F., Ortega-González, M., Carrero, J. J., Suárez, M. D., Zarzuelo, A., Sánchez de Medina, F., & Martínez-Augustin, O. (2016) · Journal of Crohn's and Colitis · doi:10.1093/ecco-jcc/jjw096 · Cited by 262 · see citing works

Interactions Between the Gut Microbiota and the Host Innate Immune Response Against Pathogens

Cheng, H.-Y., Ning, M.-X., Chen, D.-K., & Ma, W.-T. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00607 · Cited by 244 · see citing works

Taxonomic identification of commensal bacteria associated with the mucosa and digesta throughout the gastrointestinal tracts of preweaned calves

Malmuthuge, N., Griebel, P. J., & Guan, L. L. (2014) · Applied and Environmental Microbiology · doi:10.1128/aem.03864-13 · Cited by 238 · see citing works

Targeted deletion of MyD88 in intestinal epithelial cells results in compromised antibacterial immunity associated with downregulation of polymeric immunoglobulin receptor, mucin-2, and antibacterial peptides

Frantz, A. L., Rogier, E. W., Weber, C. R., Shen, L., Cohen, D. A., Fenton, L. A., Bruno, M. E. C., & Kaetzel, C. S. (2012) · Mucosal Immunology · doi:10.1038/mi.2012.23 · Cited by 230 · see citing works

Toll-Like Receptors: Regulators of the Immune Response in the Human Gut

Hug, H., Mohajeri, M., & La Fata, G. (2018) · Nutrients · doi:10.3390/nu10020203 · Cited by 217 · see citing works

Morphine induces bacterial translocation in mice by compromising intestinal barrier function in a TLR-dependent manner

Meng, J., Yu, H., Ma, J., Wang, J., Banerjee, S., Charboneau, R., Barke, R. A., & Roy, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054040 · Cited by 212 · see citing works

Immunological properties of inulin-type fructans

Vogt, L., Meyer, D., Pullens, G., Faas, M., Smelt, M., Venema, K., Ramasamy, U., Schols, H. A., & De Vos, P. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2012.656772 · Cited by 195 · see citing works

Oral administration of Proteus mirabilis damages dopaminergic neurons and motor functions in mice

Choi, J. G., Kim, N., Ju, I. G., Eo, H., Lim, S.-M., Jang, S.-E., Kim, D.-H., & Oh, M. S. (2018) · Scientific Reports · doi:10.1038/s41598-018-19646-x · Cited by 170 · see citing works

Biogeographical differences in the influence of maternal microbial sources on the early successional development of the bovine neonatal gastrointestinal tract

Yeoman, C. J., Ishaq, S. L., Bichi, E., Olivo, S. K., Lowe, J., & Aldridge, B. M. (2018) · Scientific Reports · doi:10.1038/s41598-018-21440-8 · Cited by 168 · see citing works

Antibiotic-induced dysbiosis alters host-bacterial interactions and leads to colonic sensory and motor changes in mice

Aguilera, M., Cerdà-Cuéllar, M., & Martínez, V (2015) · Gut Microbes · doi:10.4161/19490976.2014.990790 · Cited by 162 · see citing works

Clostridium ramosum regulates enterochromaffin cell development and serotonin release

Mandić, A. D., Woting, A., Jaenicke, T., Sander, A., Sabrowski, W., Rolle-Kampcyk, U., von Bergen, M., & Blaut, M. (2019) · Scientific Reports · doi:10.1038/s41598-018-38018-z · Cited by 150 · see citing works

Duodenal microbiota composition and mucosal homeostasis in pediatric celiac disease

Cheng, J., Kalliomäki, M., Heilig, H. G., Palva, A., Lähteenoja, H., de Vos, W. M., Salojärvi, J., & Satokari, R. (2013) · BMC Gastroenterology · doi:10.1186/1471-230x-13-113 · Cited by 152 · see citing works

Microbiota–neuroepithelial signalling across the gut–brain axis

Ohara, T. E., & Hsiao, E. Y. (2025) · Nature Reviews Microbiology · doi:10.1038/s41579-024-01136-9 · Cited by 147 · see citing works

Intestinal epithelial Toll-Like receptor 4 signaling affects epithelial function and colonic microbiota and promotes a risk for transmissible colitis

Dheer, R., Santaolalla, R., Davies, J. M., Lang, J. K., Phillips, M. C., Pastorini, C., Vazquez-Pertejo, M. T., & Abreu, M. T. (2016) · Infection and Immunity · doi:10.1128/iai.01374-15 · Cited by 144 · see citing works

Mechanistic links between gut microbial community dynamics, microbial functions and metabolic health

Ha, C. W. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i44.16498 · Cited by 137 · see citing works

The intestinal microbiota and host immune interactions in the critically ill

Schuijt, T. J., van der Poll, T., de Vos, W. M., & Wiersinga, W. J. (2013) · Trends in Microbiology · doi:10.1016/j.tim.2013.02.001 · Cited by 123 · see citing works

The microbiota and its metabolites in colonic mucosal health and cancer risk

Vipperla, K., & O'Keefe, S. J. (2012) · Nutrition in Clinical Practice · doi:10.1177/0884533612452012 · Cited by 116 · see citing works

Cancer Induces a Stress Ileopathy Depending on β-Adrenergic Receptors and Promoting Dysbiosis that Contributes to Carcinogenesis

Yonekura, S., Terrisse, S., Alves Costa Silva, C., Lafarge, A., Iebba, V., Ferrere, G., Goubet, A.-G., Fahrner, J.-E., Lahmar, I., Ueda, K., et al. (2022) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-0999 · Cited by 112 · see citing works

Intestinal TLR4 deletion exacerbates acute pancreatitis through gut microbiota dysbiosis and Paneth cells deficiency

Qi-Xiang, M., Yang, F., Ze-Hua, H., Nuo-Ming, Y., Rui-Long, W., Bin-Qiang, X., Jun-Jie, F., Chun-Lan, H., & Yue, Z. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2112882 · Cited by 112 · see citing works

Recurrent infection progressively disables host protection against intestinal inflammation

Yang, W. H., Heithoff, D. M., Aziz, P. V., Sperandio, M., Nizet, V., Mahan, M. J., & Marth, J. D. (2017) · Science · doi:10.1126/science.aao5610 · Cited by 104 · see citing works

Microbiota and Probiotics in Health and HIV Infection

D’Angelo, C., Reale, M., & Costantini, E. (2017) · Nutrients · doi:10.3390/nu9060615 · Cited by 97 · see citing works

Microbiota–immune system interaction: an uneasy alliance

Salzman, N. H. (2011) · Current Opinion in Microbiology · doi:10.1016/j.mib.2010.09.018 · Cited by 96 · see citing works

Glycan recognition at the interface of the intestinal immune system: target for immune modulation via dietary components

de Kivit, S., Kraneveld, A. D., Garssen, J., & Willemsen, L. E. M. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.05.086 · Cited by 94 · see citing works

Lipocalin 2 prevents intestinal inflammation by enhancing phagocytic bacterial clearance in macrophages

Toyonaga, T., Matsuura, M., Mori, K., Honzawa, Y., Minami, N., Yamada, S., Kobayashi, T., Hibi, T., & Nakase, H. (2016) · Scientific Reports · doi:10.1038/srep35014 · Cited by 75 · see citing works

NOD-like receptors in intestinal homeostasis and epithelial tissue repair

Parlato, M., & Yeretssian, G. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15069594 · Cited by 79 · see citing works

Expression and functional importance of innate immune receptors by intestinal epithelial cells

Marques, R., & Boneca, I. G. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0829-9 · Cited by 76 · see citing works

Oral Bacterial and Fungal Microbiome Impacts Colorectal Carcinogenesis

Klimesova, K., Jiraskova Zakostelska, Z., & Tlaskalova-Hogenova, H. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00774 · Cited by 67 · see citing works

The microbiotic highway to health—New perspective on food structure, gut microbiota, and host inflammation

Hansen, N. W., & Sams, A. (2018) · Nutrients · doi:10.3390/nu10111590 · Cited by 65 · see citing works

The 2016 ESPEN Arvid Wretlind lecture: The gut in stress

McClave, S. A., Lowen, C. C., & Martindale, R. G. (2018) · Clinical Nutrition · doi:10.1016/j.clnu.2017.07.015 · Cited by 63 · see citing works

Changes to the Intestinal Microbiome With Parenteral Nutrition: Review of a Murine Model and Potential Clinical Implications

Demehri, F. R., Barrett, M., & Teitelbaum, D. H. (2015) · Nutrition in Clinical Practice · doi:10.1177/0884533615609904 · Cited by 53 · see citing works

<i>Candida</i>Immunity

Naglik, J. R. (2014) · New Journal of Science · doi:10.1155/2014/390241 · Cited by 29 · see citing works

Fibrolytic Bacteria Isolated from the Rumen of North American Moose (Alces alces) and Their Use as a Probiotic in Neonatal Lambs

Ishaq, S. L., Kim, C. J., Reis, D., & Wright, A.-D. G. (2015) · PLoS ONE · doi:10.1371/journal.pone.0144804 · Cited by 29 · see citing works

Ethylene signalling and response pathway: a unique signalling cascade with a multitude of inputs and outputs

Stepanova, A. N., & Alonso, J. M. (2005) · Physiologia Plantarum · doi:10.1111/j.1399-3054.2005.00447.x · Cited by 93 · see citing works

Abiotic stress signalling pathways: specificity and cross-talk

Knight, H., & Knight, M. R. (2001) · Trends in Plant Science · doi:10.1016/s1360-1385(01)01946-x · Cited by 972 · see citing works

The signalling pathways in cancer

Hu, J., & Pezzella, F. (2019) · Oxford University Press eBooks · doi:10.1093/med/9780198779452.003.0012

Reactive Oxygen Species as Signalling Molecules

Desikan, R., Hancock, J. T., & Neill, S. J. (2005) · doi:10.1002/9780470988565.ch7 · Cited by 58 · see citing works

On the Absorption of Carbohydrates by the Intestinal Epithelium: An Experimental Inquiry into Pavy's Theory of the Action of the Epithelium on Carbohydrates

Paton, D. N., & Gulland, G. L. (1895) · Proceedings of the Royal Society of Edinburgh · doi:10.1017/s0370164600048781