Reverse electron flow-induced ROS production is attenuated by activation of mitochondrial Ca2+-sensitive K+ channels

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302

Hydroperoxide metabolism in mammalian organs.

Chance, B., Sies, H., & Boveris, A. (1979) · Physiological Reviews · doi:10.1152/physrev.1979.59.3.527 · Cited by 5,827

Mitochondrial formation of reactive oxygen species

Turrens, J. F. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.049478 · Cited by 5,084

Calcium, ATP, and ROS: a mitochondrial love-hate triangle

Brookes, P. S., Yoon, Y., Robotham, J. L., Anders, M. W., & Sheu, S.-S. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00139.2004 · Cited by 2,575

Mitochondrial dysfunction and type 2 diabetes

Lowell, B. B., & Shulman, G. I. (2005) · Science · doi:10.1126/science.1104343 · Cited by 2,070

Production of Reactive Oxygen Species by Mitochondria

Chen, Q., Vazquez, E. J., Moghaddas, S., Hoppel, C. L., & Lesnefsky, E. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304854200 · Cited by 1,616

Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria

Turrens, J. F., & Boveris, A. (1980) · Biochemical Journal · doi:10.1042/bj1910421 · Cited by 1,601

Generation of reactive oxygen species by the mitochondrial electron transport chain

Liu, Y., Fiskum, G., & Schubert, D. (2002) · Journal of Neurochemistry · doi:10.1046/j.0022-3042.2002.00744.x · Cited by 1,260

Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria

Turrens, J. F., Alexandre, A., & Lehninger, A. L. (1985) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(85)90293-0 · Cited by 1,214

Production of superoxide radicals and hydrogen peroxide by NADH-ubiquinone reductase and ubiquinol-cytochrome c reductase from beef-heart mitochondria

Cadenas, E., Boveris, A., Ragan, C. I., & Stoppani, A. O. M. (1977) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(77)90035-2 · Cited by 855

Mitochondrial reactive oxygen species production in excitable cells: Modulators of mitochondrial and cell function

Stowe, D. F., & Camara, A. K. S. (2009) · Antioxidants & Redox Signaling · doi:10.1089/ars.2008.2331 · Cited by 471

Mitochondrial Metabolism in Aging Heart

Lesnefsky, E. J., Chen, Q., & Hoppel, C. L. (2016) · Circulation Research · doi:10.1161/circresaha.116.307505 · Cited by 358

Mitochondrial Channels: Ion Fluxes and More

Szabó, I., & Zoratti, M. (2014) · Physiological Reviews · doi:10.1152/physrev.00021.2013 · Cited by 330

Mitochondrial potassium channels

Szewczyk, A. M., Jarmuszkiewicz, W., & Kunz, W. S. (2009) · IUBMB Life · doi:10.1002/iub.155 · Cited by 182

The Cardiac Mitochondrion: Nexus of Stress

Baines, C. P. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135929 · Cited by 154

BK channel activators and their therapeutic perspectives

Bentzen, B. H., Olesen, S., Rønn, L. C. B., & Grunnet, M. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00389 · Cited by 151

Mitochondrial contributions to vascular endothelial dysfunction, arterial stiffness, and cardiovascular diseases

Kirkman, D. L., Robinson, A. T., Rossman, M. J., Seals, D. R., & Edwards, D. G. (2021) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00917.2020 · Cited by 150

Biochemical regulation of the inflammasome

Dowling, J. K., & O'Neill, L. A. J. (2012) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2012.694844 · Cited by 139

Flavonoids and Mitochondria: Activation of Cytoprotective Pathways?

Kicińska, A., & Jarmuszkiewicz, W. (2020) · Molecules · doi:10.3390/molecules25133060 · Cited by 137

Different approaches to modeling analysis of mitochondrial swelling

Javadov, S. A., Chapa‐Dubocq, X. R., & Makarov, V. I. (2017) · Mitochondrion · doi:10.1016/j.mito.2017.08.004 · Cited by 138

Intracellular BK Ca (iBK Ca ) channels

Singh, H., Stefani, E., & Toro, L. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2011.215533 · Cited by 126

BK channel openers inhibit ROS production of isolated rat brain mitochondria

Kulawiak, B., Kudin, A. P., Szewczyk, A. M., & Kunz, W. S. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.05.004 · Cited by 121

Ranolazine reduces Ca2+ overload and oxidative stress and improves mitochondrial integrity to protect against ischemia reperfusion injury in isolated hearts

Aldakkak, M., Camara, A. K. S., Heisner, J. S., Yang, M., & Stowe, D. F. (2011) · Pharmacological Research · doi:10.1016/j.phrs.2011.06.018 · Cited by 116

Mitochondrial BKCa channel

Balderas, E., Zhang, J., Stefani, E., & Toro, L. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00104 · Cited by 99

Ageing and inflammation – A central role for mitochondria in brain health and disease

Currais, A. J. M. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.02.001 · Cited by 97

Mitochondrial potassium channels and reactive oxygen species

Malińska, D., Mirandola, S. R., & Kunz, W. S. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.01.013 · Cited by 94

Damage to mitochondrial complex I during cardiac ischemia reperfusion injury is reduced indirectly by anti-anginal drug ranolazine

Gadicherla, A. K., Stowe, D. F., Antholine, W. E., Yang, M., & Camara, A. K. S. (2011) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2011.11.021 · Cited by 86

Protection against cardiac injury by small Ca2+-sensitive K+ channels identified in guinea pig cardiac inner mitochondrial membrane

Stowe, D. F., Gadicherla, A. K., Zhou, Y., Aldakkak, M., Cheng, Q., Kwok, W., Jiang, M. T., Heisner, J. S., Yang, M., & Camara, A. K. S. (2012) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2012.08.031 · Cited by 88

Mitochondrial depolarization underlies delay in permeability transition by preconditioning with isoflurane: roles of ROS and Ca2+

Sedlić, F., Šepac, A., Pravdić, D., Camara, A. K. S., Bienengraeber, M., Brzezinska, A. K., Wakatsuki, T., & Bosnjak, Z. J. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00006.2010 · Cited by 83

Large-conductance Ca2+-activated potassium channel in mitochondria of endothelial EA.hy926 cells

Bednarczyk, P., Kozieł, A., Jarmuszkiewicz, W., & Szewczyk, A. M. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00976.2012 · Cited by 78

Physiology of potassium channels in the inner membrane of mitochondria

Szabó, I., Leanza, L., Gulbins, E., & Zoratti, M. (2011) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-011-1058-7 · Cited by 76

Mitochondrial Ca2+-activated K+ channels and their role in cell life and death pathways

Krabbendam, I. E., Honrath, B., Culmsee, C., & Dolga, A. M. (2017) · Cell Calcium · doi:10.1016/j.ceca.2017.07.005 · Cited by 76

Mild uncoupling of respiration and phosphorylation as a mechanism providing nephro- and neuroprotective effects of penetrating cations of the SkQ family

Plotnikov, E. Y., Silachev, D. N., Jankauskas, S. S., Rokitskaya, T. I., Chupyrkina, A. A., Pevzner, I. B., Zorova, L. D., Исаев, Н. К., Antonenko, Y. N., Skulachev, V. P., et al. (2012) · Biochemistry (Moscow) · doi:10.1134/s0006297912090106 · Cited by 72

The Human Mitochondrial DNA Depletion Syndrome Gene MPV17 Encodes a Non-selective Channel That Modulates Membrane Potential

Antonenkov, V. D., Isomursu, A., Mennerich, D., Vapola, M. H., Weiher, H., Kietzmann, T., & Hiltunen, J. K. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.608083 · Cited by 69

Oxidative Stress and Maxi Calcium-Activated Potassium (BK) Channels

Hermann, A., Ситдикова, Г. Ф., & Weiger, T. M. (2015) · Biomolecules · doi:10.3390/biom5031870 · Cited by 68

Redox Control of Cardiac Excitability

Aggarwal, N. T., & Makielski, J. C. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4234 · Cited by 62

Reactive oxygen species production in cardiac mitochondria after complex I inhibition: Modulation by substrate-dependent regulation of the NADH/NAD+ ratio

Kôrge, P., Calmettes, G., & Weiss, J. N. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.04.002 · Cited by 59

Mitochondrial matrix K+flux independent of large-conductance Ca2+-activated K+channel opening

Aldakkak, M., Stowe, D. F., Cheng, Q., Kwok, W., & Camara, A. K. S. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00468.2009 · Cited by 54

Impact of intracellular ion channels on cancer development and progression

Peruzzo, R., Biasutto, L., Szabó, I., & Leanza, L. (2016) · European Biophysics Journal · doi:10.1007/s00249-016-1143-0 · Cited by 50

Expression and Activation of BKCa Channels in Mice Protects Against Ischemia-Reperfusion Injury of Isolated Hearts by Modulating Mitochondrial Function

Goswami, S. K., Ponnalagu, D., Hussain, A. T., Shah, K. J., Karekar, P., Rao, S. G., Meredith, A. L., Khan, M., & Singh, H. (2019) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2018.00194 · Cited by 47

Reverse electron flow-mediated ROS generation in ischemia-damaged mitochondria: Role of complex I inhibition vs. depolarization of inner mitochondrial membrane

Ross, T., Szczepanek, K., Bowler, E., Hu, Y., Larner, A. C., Lesnefsky, E. J., & Chen, Q. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.05.035 · Cited by 48

Mitochondrial but not plasmalemmal BK channels are hypoxia‐sensitive in human glioma

Gu, X. Q., Pamenter, M. E., Siemen, D., Sun, X., & Haddad, G. G. (2014) · Glia · doi:10.1002/glia.22620 · Cited by 45

Isoflurane protects cardiomyocytes and mitochondria by immediate and cytosol‐independent action at reperfusion

Pravdić, D., Mio, Y., Sedlić, F., Pratt, P. F., Warltier, D., Bosnjak, Z., & Bienengraeber, M. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00698.x · Cited by 44

High Yields of Hydrogen Production Induced by Meta-Substituted Dichlorophenols Biodegradation from the Green Alga Scenedesmus obliquus

Papazi, A., Andronis, E. A., Ioannidis, N. E., Chaniotakis, N. A., & Kotzabasis, K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049037 · Cited by 45

Isoflurane modulates cardiac mitochondrial bioenergetics by selectively attenuating respiratory complexes

Agarwal, B., Dash, R. K., Stowe, D. F., Bosnjak, Z. J., & Camara, A. K. S. (2013) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2013.11.006 · Cited by 41

Dynamic buffering of mitochondrial Ca2+ during Ca2+ uptake and Na+-induced Ca2+ release

Blomeyer, C. A., Bazil, J. N., Stowe, D. F., Pradhan, R. K., Dash, R. K., & Camara, A. K. S. (2012) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-012-9483-7 · Cited by 41

Pharmacological activation of mitochondrial BK Ca channels protects isolated cardiomyocytes against simulated reperfusion-induced injury

Borchert, G. H., Hlaváčková, M., & Kolář, F. (2013) · Experimental Biology and Medicine · doi:10.1177/1535370212474596 · Cited by 41

Tyrosine nitration of voltage-dependent anion channels in cardiac ischemia-reperfusion: reduction by peroxynitrite scavenging

Yang, M., Camara, A. K. S., Wakim, B. T., Zhou, Y., Gadicherla, A. K., Kwok, W., & Stowe, D. F. (2012) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2012.06.004 · Cited by 40

Signaling pathways targeting mitochondrial potassium channels

Rotko, D., Kunz, W. S., Szewczyk, A. M., & Kulawiak, B. (2020) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2020.105792 · Cited by 40

Uridine treatment prevents myocardial injury in rat models of acute ischemia and ischemia/reperfusion by activating the mitochondrial ATP-dependent potassium channel

Крылова, И. Б., Selina, E. N., Bulion, V. V., Rodionova, O. M., Evdokimova, N. R., Belosludtseva, N. V., Shigaeva, M. I., & Mironova, G. D. (2021) · Scientific Reports · doi:10.1038/s41598-021-96562-7 · Cited by 41

Hemin inhibits the large conductance potassium channel in brain mitochondria: A putative novel mechanism of neurodegeneration

Augustynek, B., Kudin, A. P., Bednarczyk, P., Szewczyk, A. M., & Kunz, W. S. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.04.022 · Cited by 36

The Slo(w) path to identifying the mitochondrial channels responsible for ischemic protection

Smith, C. O., Nehrke, K. W., & Brookes, P. S. (2017) · Biochemical Journal · doi:10.1042/bcj20160623 · Cited by 40

Single channel properties of mitochondrial large conductance potassium channel formed by BK-VEDEC splice variant

Gałecka, S., Kulawiak, B., Bednarczyk, P., Singh, H., & Szewczyk, A. M. (2021) · Scientific Reports · doi:10.1038/s41598-021-90465-3 · Cited by 30

Multidimensional Regulation of Cardiac Mitochondrial Potassium Channels

Kulawiak, B., Bednarczyk, P., & Szewczyk, A. M. (2021) · Cells · doi:10.3390/cells10061554 · Cited by 30

Reversible Blockade of Complex I or Inhibition of PKCβ Reduces Activation and Mitochondria Translocation of p66Shc to Preserve Cardiac Function after Ischemia

Yang, M., Stowe, D. F., Udoh, K. B., Heisner, J. S., & Camara, A. K. S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113534 · Cited by 29

Mitochondrial handling of excess Ca2+ is substrate-dependent with implications for reactive oxygen speciesgeneration

Aldakkak, M., Stowe, D. F., Dash, R. K., & Camara, A. K. S. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.09.020 · Cited by 30

Pharmacological options to protect the aged heart from ischemia and reperfusion injury by targeting the PKA–BKCa signaling pathway

Heinen, A., Stroethoff, M., Schmidt, A., Stracke, N., Behmenburg, F., Bauer, I., Hollmann, M. W., & Huhn, R. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.03.029 · Cited by 29

Complex I and ATP synthase mediate membrane depolarization and matrix acidification by isoflurane in mitochondria

Pravdić, D., Hirata, N., Barber, L., Sedlić, F., Bosnjak, Z. J., & Bienengraeber, M. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.07.003 · Cited by 28

Lower muscle mitochondrial energetics is associated with greater phenotypic frailty in older women and men: the Study of Muscle, Mobility and Aging

Mau, T., Barnes, H. N., BLACKWELL, T. L., Kramer, P. A., Bauer, S. R., Marcinek, D. J., Ramos, S. V., Forman, D. E., Toledo, F. G. S., Hepple, R. T., et al. (2023) · GeroScience · doi:10.1007/s11357-023-01002-1 · Cited by 27

Functional Role of Mitochondrial and Nuclear BK Channels

Li, B., & Gao, T. (2016) · International review of neurobiology · doi:10.1016/bs.irn.2016.03.018 · Cited by 25

Ca2+-Activated K+ Channels as Therapeutic Targets for Myocardial and Vascular Protection

Clements, R., Terentyev, D. A., & Sellke, F. W. (2015) · Circulation Journal · doi:10.1253/circj.cj-15-0015 · Cited by 26

BK in Double-Membrane Organelles: A Biophysical, Pharmacological, and Functional Survey

González-Sanabria, N., Echeverría, F., Segura, I. A., Alvarado-Sánchez, R., & Latorre, R. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.761474 · Cited by 25

Endogenous and Agonist-induced Opening of Mitochondrial Big Versus Small Ca2+-sensitive K+ Channels on Cardiac Cell and Mitochondrial Protection

Stowe, D. F., Yang, M., Heisner, J. S., & Camara, A. K. S. (2017) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000524 · Cited by 24

Revisiting the Large-Conductance Calcium-Activated Potassium (BKCa) Channels in the Pulmonary Circulation

Guntur, D., Olschewski, H., Enyedi, P., Csáki, R., Olschewski, A., & Nagaraj, C. (2021) · Biomolecules · doi:10.3390/biom11111629 · Cited by 23

Redox-dependent loss of flavin by mitochondria complex I is different in brain and heart

Yoval‐Sánchez, B., Ansari, F., James, J., Niatsetskaya, Z. V., Sosunov, S. A., Filipenko, P., Tikhonova, I. G., Ten, V. S., Wittig, I., Rafikov, R., et al. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102258 · Cited by 23

Milrinone-Induced Pharmacological Preconditioning in Cardioprotection: Hints for a Role of Mitochondrial Mechanisms

Raupach, A., Reinle, J., Stroethoff, M., Mathes, A., Heinen, A., Hollmann, M. W., Huhn, R., & Bunte, S. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8040507 · Cited by 22

The regulation of mitochondrial respiration by opening of mKCa channels is age-dependent

Heinen, A., Winning, A., Schlack, W. S., Hollmann, M. W., Preckel, B., Fräβdorf, J., & Weber, N. C. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.09.008 · Cited by 22

Rottlerin Increases Cardiac Contractile Performance and Coronary Perfusion Through BK Ca++ Channel Activation After Cold Cardioplegic Arrest in Isolated Hearts

Clements, R., Cordeiro, B., Feng, J., Bianchi, C. F., & Sellke, F. W. (2011) · Circulation · doi:10.1161/circulationaha.110.012112 · Cited by 21

Mitochondrial BK Channel Openers CGS7181 and CGS7184 Exhibit Cytotoxic Properties

Augustynek, B., Koprowski, P., Rotko, D., Kunz, W. S., Szewczyk, A. M., & Kulawiak, B. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19020353 · Cited by 21

Inhibition of BKCanegatively alters cardiovascular function

Patel, N. H., Johannesen, J., Shah, K. J., Goswami, S. K., Patel, N., Ponnalagu, D., Kohut, A. R., & Singh, H. (2018) · Physiological Reports · doi:10.14814/phy2.13748 · Cited by 21

Loss of the large conductance calcium-activated potassium channel causes an increase in mitochondrial reactive oxygen species in glioblastoma cells

Kulawiak, B., Żochowska, M., Bednarczyk, P., Galuba, A., Stroud, D. A., & Szewczyk, A. M. (2023) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-023-02833-9 · Cited by 20

Mitochondrialne kanały potasowe: podsumowanie

Szewczyk, A. M., Bednarczyk, P., Jędraszko, J., Kampa, R. P., Koprowski, P., Krajewska, M., Kucman, S. K., Kulawiak, B., Laskowski, M., Rotko, D., et al. (2018) · Postępy Biochemii · doi:10.18388/pb.2018_132 · Cited by 21

Enhanced charge-independent mitochondrial free Ca2+ and attenuated ADP-induced NADH oxidation by isoflurane: Implications for cardioprotection

Agarwal, B., Camara, A. K. S., Stowe, D. F., Bosnjak, Z. J., & Dash, R. K. (2011) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2011.11.011 · Cited by 19

Targeting Mitochondrial Large-Conductance Calcium-Activated Potassium Channel by Hydrogen Sulfide via Heme-Binding Site

Walewska, A., Szewczyk, A. M., Krajewska, M., & Koprowski, P. (2022) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.121.001017 · Cited by 17

SERCA, complex I of the respiratory chain and ATP-synthase inhibition are involved in pleiotropic effects of NS1619 on endothelial cells

Łukasiak, A., Skup, A., Chłopicki, S., Łomnicka, M., Kaczara, P., Proniewski, B., Szewczyk, A. M., & Wrzosek, A. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.05.039 · Cited by 17

Effectors of large-conductance calcium-activated potassium channel modulate glutamate excitotoxicity in organotypic hippocampal slice cultures

Piwońska, M., Szewczyk, A. M., Schröder, U. H., Reymann, K. G., & Bednarczyk, P. (2016) · Acta Neurobiologiae Experimentalis · doi:10.21307/ane-2017-002 · Cited by 17

Dissecting the molecular mechanism by which NH2htau and Aβ1-42 peptides impair mitochondrial ANT-1 in Alzheimer disease

Bobba, A., Amadoro, G., Petragallo, V. A., Calissano, P., & Atlante, A. (2013) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2013.04.001 · Cited by 17

Closure of mitochondrial potassium channels favors opening of the Tl+-induced permeability transition pore in Ca2+-loaded rat liver mitochondria

Korotkov, S. M., Brailovskaya, I. V., Shumakov, A. R., & Emelyanova, L. V. (2015) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-015-9611-2 · Cited by 15

Specific BK Channel Activator NS11021 Protects Rat Renal Proximal Tubular Cells from Cold Storage—Induced Mitochondrial Injury In Vitro

Shrum, S., Rusch, N. J., & MacMillan-Crow, L. A. (2019) · Biomolecules · doi:10.3390/biom9120825 · Cited by 14

The mitochondrial bioenergetic phenotype for protection from cardiac ischemia in SUR2 mutant mice

Aggarwal, N. T., Pravdić, D., McNally, E. M., Bosnjak, Z. J., Shi, N., & Makielski, J. C. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00363.2010 · Cited by 14

Inhibition of BKCa channels protects neonatal hearts against myocardial ischemia and reperfusion injury

Sanghvi, S. K., Szteyn, K., Ponnalagu, D., Sridharan, D., Lam, A., Hansra, I., Chaudhury, A., Majumdar, U., Kohut, A. R., Rao, S. G., et al. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-00980-z · Cited by 13

Effects of isoflurane on complex II‑associated mitochondrial respiration and reactive oxygen species production: Roles of nitric oxide and mitochondrial KATP channels

Wang, J., Sun, J., Qiao, S., Li, H., Che, T., Wang, C., & An, J. (2019) · Molecular Medicine Reports · doi:10.3892/mmr.2019.10658 · Cited by 13

Abscisic Acid and Its Receptors LANCL1 and LANCL2 Control Cardiomyocyte Mitochondrial Function, Expression of Contractile, Cytoskeletal and Ion Channel Proteins and Cell Proliferation via ERRα

Spinelli, S., Guida, L., Passalacqua, M., Magnone, M., Cossu, V., Sambuceti, G., Marini, C., Sturla, L., & Zocchi, E. (2023) · Antioxidants · doi:10.3390/antiox12091692 · Cited by 12

Time and charge/pH-dependent activation of K+ channel-mediated K+ influx and K+/H+ exchange in guinea pig heart isolated mitochondria; role in bioenergetic stability

Malas, K. M., Lambert, D. S., Heisner, J. S., Camara, A. K. S., & Stowe, D. F. (2022) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2022.148908 · Cited by 11

Potassium Ions Decrease Mitochondrial Matrix pH: Implications for ATP Production and Reactive Oxygen Species Generation

Naima, J., & Ohta, Y. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021233 · Cited by 10

Cytoprotective action of the potassium channel opener NS1619 under conditions of disrupted calcium homeostasis

Chmielewska, L., & Malińska, D. (2011) · Pharmacological Reports · doi:10.1016/s1734-1140(11)70413-3 · Cited by 9

Differential programming of p53-deficient embryonic cells during rotenone block

Green, M. L., Singh, A. V., Ruest, L. B., Pisano, M., Prough, R. A., & Knudsen, T. B. (2011) · Toxicology · doi:10.1016/j.tox.2011.08.013 · Cited by 9

Opening of Intermediate Conductance Ca2+-Activated K+ Channels in C2C12 Skeletal Muscle Cells Increases the Myotube Diameter via the Akt/Mammalian Target of Rapamycin Pathway

Iseki, Y., Ono, Y., Hibi, C., Tanaka, S., Takeshita, S., Maejima, Y., Kurokawa, J., Murakawa, M., Shimomura, K., & Sakamoto, K. (2020) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.120.000290 · Cited by 6

Inhibitory Effects of Thyroid Hormones on Mitochondrial Oxidative Stress: A Systematic Review

Goharbari, M. H., Shadboorestan, A., & Abdollahi, M. R. (2016) · International Journal of Pharmacology · doi:10.3923/ijp.2016.249.261 · Cited by 6

Oxidative stress in schistosomiasis, echinococcosis, and trypanosomiasis: a therapeutic approach

Ghosh, S., Das, A. K., Sarkar, P., & Sil, P. C. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815723-7.00006-7 · Cited by 6

Combined high-fat, high-sucrose diet and streptozotocin treatment induces cardiometabolic heart failure with preserved ejection fraction in mice

Heinen, A., Spychala, A., Ballmann, L., Gödecke, S., Faradj, Z., Bresch, F., Krüger, M., Bottermann, K., Zabri, H., Fischer, J. W., et al. (2026) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00843.2025 · Cited by 5

The effect of modulators of large-conductance Ca2+-modulated K+ channels on rat AS-30D ascites hepatoma cells and isolated liver mitochondria treated with Cd2+

Belyaeva, E. A. (2015) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s0022093015040018 · Cited by 3

Reactive Oxygen Species (ROS) and Cardiac Ischemia and Reperfusion Injury

Camara, A. K. S., & Stowe, D. F. (2014) · Springer eBooks · doi:10.1007/978-3-642-30018-9_75 · Cited by 3

A potent and selective activator of large‐conductance Ca2+‐activated K+ channels induces preservation of mitochondrial function after hypoxia and reoxygenation by handling of calcium and transmembrane potential

de Souza, I. I. A., Barenco, T. D. S., Pavarino, M. E. M. F., Couto, M. T., de Resende, G. O., de Oliveira, D. F., Ponte, C. G., Nascimento, J. H. M., & Maciel, L. (2024) · Acta Physiologica · doi:10.1111/apha.14151 · Cited by 2

Process of Oxidative Phosphorylation and Free Radical Generation

Stowe, D. F. (2025) · Springer eBooks · doi:10.1007/978-3-031-76668-8_6 · Cited by 2

Diabetic heart shows preferential secretion of inner mitochondrial membrane proteins in the presence of mitochondrial oxidative stress

Miotto, P. M., Bayliss, J. A., Fidelito, G., Bell, J. R., Delbridge, L. M. D., Watt, M. J., & Montgomery, M. K. (2025) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00073.2025 · Cited by 3

Physiology and Molecular Biology of Ion Channels Underlying Ventricular Repolarization of the Mammalian Heart

Comollo, T. W., Zhang, C., Zou, X., & Kass, R. S. (2019) · Springer eBooks · doi:10.1007/978-3-030-22672-5_1 · Cited by 2

Mitigating effect of paxilline against injury produced by Cd2+ in rat pheochromocytoma PC12 and ascites hepatoma AS-30D cells

Belyaeva, E. A., & Соколова, Т. В. (2020) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2020.110519 · Cited by 2

Effect of Large-Conductance Calcium-Dependent K+ Channel Activator NS1619 on Function of Mitochondria in the Heart of Dystrophin-Deficient Mice

Dubinin, M. V., Starinets, V. S., Chelyadnikova, Y. A., Belosludtseva, N. V., Mikheeva, I. B., Penkina, D. K., Igoshkina, A. D., Talanov, E. Y., Kireev, I. I., Zorov, D. B., et al. (2023) · Biochemistry (Moscow) · doi:10.1134/s0006297923020037 · Cited by 2

Loss of cardiomyocyte AKT signaling causes deterioration of lipid metabolism and cellular atrophy

Gödecke, S., Heinen, A., Appel, T., Müller, P., Stemmer, T., Müller, D., Flögel, U., Herebian, D., Solari, F. A., Deenen, R., et al. (2026) · Metabolism · doi:10.1016/j.metabol.2026.156619 · Cited by 1

Mitochondrial Reactive Oxygen Species in Myocardial Pre- and Postconditioning

Cardoso, A. R., Queliconi, B. B., & Kowaltowski, A. J. (2010) · Humana Press eBooks · doi:10.1007/978-1-60761-600-9_5 · Cited by 1

Effect of the large-conductance calcium-dependent k+ channel activator NS1619 on the function of mitochondria in the heart of dystrophin-deficient mice

Dubinin, M. V., Starinets, V. S., Chelyadnikova, Y. A., Belosludtseva, N. V., Mikheeva, I. B., Penkina, D. K., Igoshkina, A. D., Talanov, E. Y., & Kireev, I. I. (2023) · Biochemistry (Moscow) · doi:10.31857/s0320972523020045 · Cited by 1

Regulation of mitochondrial potassium BKCa channel by naringenin derivatives: application of a new cellular model

Sęk, A., Cammarone, S., Kampa, R. P., Pytlak, K., Kalenik, B., Lewandowska, J., Ghirga, F., Romeo, I., Atrooz, O. M., Bednarczyk, P., et al. (2025) · European Journal of Medicinal Chemistry Reports · doi:10.1016/j.ejmcr.2025.100304 · Cited by 1

Reactive Oxygen and Nitrogen Species Signaling in Mitochondria

(2009) · CRC Press eBooks · doi:10.1201/9781420073751.ch3 · Cited by 1

The role of mitochondria in cardioprotection

Heinen, A. (2008) · UvA-DARE (University of Amsterdam)

CALL FOR PAPERS Mitochondria in Cardiovascular Physiology and Disease Large-conductance Ca 2 -activated potassium channel in mitochondria of endothelial EA.hy926 cells

Bednarczyk, P., Kozieł, A., Jarmuszkiewicz, W., & Szewczyk, A. M. (2013)

Effect of thallium on mitochondria

Korotkov, S. M. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-95531-7.00002-1

Benzimidazole Derivative NS1619 Inhibits Functioning of Mitochondria Isolated from Mouse Skeletal Muscle

Dubinin, M. V., Igoshkina, A. D., Semenova, A. A., Mikina, N. V., Khoroshavina, E. I., & Belosludtsev, K. N. (2023) · Biochemistry (Moscow) Supplement Series A Membrane and Cell Biology · doi:10.1134/s1990747823030066

Benzimidazole Derivative NS1619 Inhibits Functioning of Mitochondria Isolated from Mouse Skeletal Muscle

Dubinin, M. V., Igoshkina, A. D., Semenova, A. A., Mikina, N. V., Khoroshavina, E. I., & Belosludtsev, K. N. (2023) · Биологические мембраны Журнал мембранной и клеточной биологии · doi:10.31857/s0233475523030064

Ionic and Molecular Regulation of Mitochondrial Bioenergetics

Stowe, D. F. (2025) · Springer eBooks · doi:10.1007/978-3-031-76668-8_7

Mitochondrial Ca2+-induced K+ influx increases respiration and enhances ROS production while maintaining membrane potential

Heinen, A., Camara, A. K. S., Aldakkak, M., Rhodes, S. S., Riess, M. L., & Stowe, D. F. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00215.2006 · Cited by 128

Computational Analysis of Reactive Oxygen Species Generation by Mitochondria Resulting from Substrate Manipulation

Kumar, R., & Jafri, M. S. (2013) · Biophysical Journal · doi:10.1016/j.bpj.2012.11.1696

Reactive Oxygen Species Production by Forward and Reverse Electron Fluxes in the Mitochondrial Respiratory

Selivanov, V. A., Votyakova, T. V., Pivtoraiko, V. N., Zeak, J. A., Trucco, M., Roca, J., & Cascante, M. (2013)

Reactive oxygen species are generated by the respiratory complex II – evidence for lack of contribution of the reverse electron flow in complex I

Moreno‐Sánchez, R., Hernández‐Esquivel, L., Rivero‐Segura, N. A., Marín‐Hernández, A., Neuzil, J., Ralph, S. J., & Rodríguez‐Enríquez, S. (2013) · The FEBS Journal · doi:10.1111/febs.12086 · Cited by 100

Opening mitoKATPincreases superoxide generation from complex I of the electron transport chain

Andrukhiv, A., Costa, A. D. T., West, I. C., & Garlid, K. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00272.2006 · Cited by 224