The DOI matches its Crossref record; 91 of the 91 references it cites were found in a registry or an index.
Cardiovascular response to thermoregulatory challenges
Open accessAbstract
A growing number of extreme climate events are occurring in the setting of ongoing climate change, with an increase in both the intensity and frequency. It has been shown that ambient temperature challenges have a direct and highly varied impact on cardiovascular health. With a rapidly growing amount of literature on this issue, we aim to review the recent publications regarding the impact of cold and heat on human populations with regard to cardiovascular disease (CVD) mortality/morbidity while also examining lag effects, vulnerable subgroups, and relevant mechanisms. Although the relative risk of morbidity/mortality associated with extreme temperature varied greatly across different studies, both cold and hot temperatures were associated with a positive mean excess of cardiovascular deaths or hospital admissions. Cause-specific study of CVD morbidity/mortality indicated that the sensitivity to temperature was disease-specific, with different patterns for acute and chronic ischemic heart disease. Vulnerability to temperature-related mortality was associated with some characteristics of the populations, including sex, age, location, socioeconomic condition, and comorbidities such as cardiac diseases, kidney diseases, diabetes, and hypertension. Temperature-induced damage is thought to be related to enhanced sympathetic reactivity followed by activation of the sympathetic nervous system, renin-angiotensin system, as well as dehydration and a systemic inflammatory response. Future research should focus on multidisciplinary adaptation strategies that incorporate epidemiology, climatology, indoor/building environments, energy usage, labor legislative perfection, and human thermal comfort models. Studies on the underlying mechanism by which temperature challenge induces pathophysiological response and CVD await profound and lasting investigation.
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Cites
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Cited by
Heat-related mortality in Europe during the summer of 2022
Ballester, J., Quijal-Zamorano, M., Méndez Turrubiates, R. F., Pegenaute, F., Herrmann, F. R., Robine, J. M., Basagaña, X., Tonne, C., Antó, J. M., & Achebak, H. (2023) · Nature Medicine · doi:10.1038/s41591-023-02419-z · Cited by 1,018
Alahmad, B., Khraishah, H., Royé, D., Vicedo-Cabrera, A. M., Guo, Y., Papatheodorou, S. I., Achilleos, S., Acquaotta, F., Armstrong, B., Bell, M. L., et al. (2023) · Circulation · doi:10.1161/circulationaha.122.061832 · Cited by 448
Seasonal variations in cardiovascular disease
Stewart, S., Keates, A. K., Redfern, A., & McMurray, J. J. V. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2017.76 · Cited by 328
Stergiou, G. S., Palatini, P., Modesti, P. A., Asayama, K., Asmar, R., Bilo, G., de la Sierra, A., Dolan, E., Head, G., Kario, K., et al. (2020) · Journal of Hypertension · doi:10.1097/hjh.0000000000002341 · Cited by 130
Metadata
- Authors
- Liu, C., Yavar, Z., & Sun, Q.
- Venue
- American Journal of Physiology-Heart and Circulatory Physiology
- Publisher
- American Physiological Society
- Published
- 2015-12-01
- Volume
- 309
- Issue
- 11
- Pages
- H1793-H1812
- ISSN
- 0363-6135 (ISSN-L)
- 1522-1539
- OpenAlex
- W2181358502
- Cited by
- 363
- References
- 91
- FWCI
- 6.13
- Type
- journal article
- Language
- en
- Open access
- green
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