The DOI matches its Crossref record; 204 of the 204 references it cites were found in a registry or an index.
Cellular senescence links aging and diabetes in cardiovascular disease
Open accessAbstract
Aging is a powerful independent risk factor for cardiovascular diseases such as atherosclerosis and heart failure. Concomitant diabetes mellitus strongly reinforces this effect of aging on cardiovascular disease. Cellular senescence is a fundamental mechanism of aging and appears to play a crucial role in the onset and prognosis of cardiovascular disease in the context of both aging and diabetes. Senescent cells are in a state of cell cycle arrest but remain metabolically active by secreting inflammatory factors. This senescence-associated secretory phenotype is a trigger of chronic inflammation, oxidative stress, and decreased nitric oxide bioavailability. A complex interplay between these three mechanisms results in age- and diabetes-associated cardiovascular damage. In this review, we summarize current knowledge on cellular senescence and its secretory phenotype, which might be the missing link between aging and diabetes contributing to cardiovascular disease.
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“These persisting senescent cells have been recently tied to multiple chronic diseases other than atherosclerosis, including diabetes mellitus,85 obesity,85 Alzheimer’s disease,86 heart failure,10,87 idiopathic pulmonary fibrosis,88,89 chronic obstructive pulmonary disease,90 chronic kidney disease,91 cancer,92 and osteoarthritis.93”
From Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosis (2020) · cites this paper as [85]
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Items 201–204 of 204
Pathophysiology of Diastolic Dysfunction in Chronic Heart Failure
Segers, V. F. M., & Keulenaer, G. W. D. (2013) · Future Cardiology · doi:10.2217/fca.13.53 · Cited by 11
Self-citationRangel-Zúñiga, O. A., Corina, A., Lucena-Porras, B., Cruz-Teno, C., Gómez-Delgado, F., Jiménez-Lucena, R., Alcalá-Díaz, J. F., Haro-Mariscal, C., Yubero-Serrano, E. M., Delgado-Lista, J., et al. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.07.015 · Cited by 11
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Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty
Ferrucci, L., & Fabbri, E. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0064-2 · Cited by 3,690
Han, Y., & Kim, S. Y. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00906-w · Cited by 201
Immune Clearance of Senescent Cells to Combat Ageing and Chronic Diseases
Song, P., An, J., & Zou, M.-H. (2020) · Cells · doi:10.3390/cells9030671 · Cited by 198
“However, excessive accumulation of senescent cells causally shortens the healthy lifespan [11] and drives organ ageing [12], age-related organ deterioration/disorders [13,14], tissue dysfunction and chronic diseases, including cardiovascular diseases (CVDs) [15,16], cancer [2], neurodegenerative diseases [17,18] and o…”
BackgroundSenescence-induced inflammation: an important player and key therapeutic target in atherosclerosis
Stojanović, S. D., Fiedler, J., Bauersachs, J., Thum, T., & Sedding, D. G. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz919 · Cited by 188
Vascular Ageing: Mechanisms, Risk Factors, and Treatment Strategies
Ya, J., & Bayraktutan, U. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411538 · Cited by 57
Metadata
- Authors
- Shakeri, H., Lemmens, K., Gevaert, A. B., De Meyer, G. R. Y., & Segers, V. F. M.
- Affiliations
- University of Antwerp (BE)
- Laboratory of Physiopharmacology, University of Antwerp, Antwerp, Belgium
- Corresponding author
- Segers, Vincent F. M.
- Venue
- American Journal of Physiology-Heart and Circulatory Physiology
- Publisher
- American Physiological Society
- Published
- 2018-09-01
- Volume
- 315
- Issue
- 3
- Pages
- H448-H462
- ISSN
- 0363-6135 (ISSN-L)
- 1522-1539
- OpenAlex
- W2802682414
- Cited by
- 134
- References
- 204
- Citations by year
- 2026: 17 · 2025: 20 · 2024: 23 · 2023: 16 · 2022: 16 · 2021: 16 · 2020: 9 · 2019: 9 · 2018: 7
- FWCI
- 1.35
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Physiology-Heart and Circulatory Physiology (publishedVersion)
- PubMed (publishedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion, other-oa)
- Funders
- University of Antwerp (IOF-SBO)
- FWO (1.5.011.18N)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- cellular senescence, aging, diabetes mellitus, cardiovascular disease, senescence-associated secretory phenotype, chronic inflammation, oxidative stress, nitric oxide bioavailability, atherosclerosis, heart failure, cell cycle arrest
- MeSH terms
- Aging, Animals, Cardiovascular Diseases, Diabetes Mellitus, Humans, Cellular Senescence
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