Cited by 134Telomeres, Telomerase, and SenescenceSirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model Organisms

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Cellular senescence links aging and diabetes in cardiovascular disease

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Shakeri, Hadis, Lemmens, Katrien, Gevaert, Andreas B., De Meyer, Guido R. Y., Segers, Vincent F. M.·2018·American Journal of Physiology-Heart and Circulatory Physiology

DOI 10.1152/ajpheart.00287.2018

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Abstract

Aging is a powerful independent risk factor for cardiovascular diseases such as atherosclerosis and heart failure. Concomitant diabetes mellitus strongly reinforces this effect of aging on cardiovascular disease. Cellular senescence is a fundamental mechanism of aging and appears to play a crucial role in the onset and prognosis of cardiovascular disease in the context of both aging and diabetes. Senescent cells are in a state of cell cycle arrest but remain metabolically active by secreting inflammatory factors. This senescence-associated secretory phenotype is a trigger of chronic inflammation, oxidative stress, and decreased nitric oxide bioavailability. A complex interplay between these three mechanisms results in age- and diabetes-associated cardiovascular damage. In this review, we summarize current knowledge on cellular senescence and its secretory phenotype, which might be the missing link between aging and diabetes contributing to cardiovascular disease.

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Authors: Shakeri, H., Lemmens, K., Gevaert, A. B., De Meyer, G. R. Y., & Segers, V. F. M.
Affiliations: University of Antwerp (BE)
Laboratory of Physiopharmacology, University of Antwerp, Antwerp, Belgium
Corresponding author: Segers, Vincent F. M.
ORCID: Gevaert, Andreas B.
Segers, Vincent F. M.
Venue: American Journal of Physiology-Heart and Circulatory Physiology
Publisher: American Physiological Society
Published: 2018-09-01
Volume: 315
Issue: 3
Pages: H448-H462
ISSN: 0363-6135 (ISSN-L)
1522-1539
DOI: 10.1152/ajpheart.00287.2018
OpenAlex: W2802682414
Cited by: 134
References: 204
Citations by year: 2026: 17 · 2025: 20 · 2024: 23 · 2023: 16 · 2022: 16 · 2021: 16 · 2020: 9 · 2019: 9 · 2018: 7
FWCI: 1.35
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: American Journal of Physiology-Heart and Circulatory Physiology (publishedVersion)
PubMed (publishedVersion)
Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion, other-oa)
Funders: University of Antwerp (IOF-SBO)
FWO (1.5.011.18N)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords: cellular senescence, aging, diabetes mellitus, cardiovascular disease, senescence-associated secretory phenotype, chronic inflammation, oxidative stress, nitric oxide bioavailability, atherosclerosis, heart failure, cell cycle arrest
MeSH terms: Aging, Animals, Cardiovascular Diseases, Diabetes Mellitus, Humans, Cellular Senescence

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Cellular senescence links aging and diabetes in cardiovascular disease

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