The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
SARS-CoV-2 infection downregulates myocardial ACE2 and potentiates cardiac inflammation in humans and hamsters
Open accessAbstract
Cardiac manifestations of COVID-19 in humans are mirrored in the SARS-CoV-2 hamster model, recapitulating myocardial damage, ACE2 downregulation, and a consistent pattern of immune cell infiltration independent of viral dose and variant. Therefore, the hamster model is a valid approach to study therapeutic strategies for COVID-19-related heart disease.
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SARS-CoV-2 infection of male Syrian hamsters caused viral infection and induced inflammation in the heart according to quantitative real-time PCR and immunohistochemistry, but myocardial foci were not described.
“SARS-CoV-2 infection of male Syrian hamsters caused viral infection and induced inflammation in the heart according to quantitative real-time PCR and immunohistochemistry (individually positive cells), but myocardial foci were not described. 182”
From COVID-19, Myocarditis and Pericarditis (2023) · cites this paper as [182]
Increased CD15+ cells, CD68+ macrophages, and CD4 and CD8 T cells were found in the heart in SARS-CoV-2-infected hamsters, but mast cells were not specifically examined.
“They found increased CD15+ cells (a marker of myeloid cells such as granulocytes, neutrophils, eosinophils, mast cells, and macrophages), CD68+ macrophages, and CD4 and CD8 T cells in the heart in SARS-CoV2-infected hamsters, but they did not specifically examine mast cells. 182”
From COVID-19, Myocarditis and Pericarditis (2023) · cites this paper as [182]
The immune response (dominant macrophages with fewer T cells) is typical of EAM, autoimmune CVB3 myocarditis, and human myocarditis in males.
“This immune response (ie, dominant macrophages with fewer T cells) is typical of EAM, autoimmune CVB3 myocarditis, and human myocarditis in males (Figure 2). 182,184,185”
From COVID-19, Myocarditis and Pericarditis (2023) · cites this paper as [182]
Increased TNFα and IL-1β in the heart and perivascular fibrosis were found, which typically indicates perivascular mast cell degranulation.
“They also found increased TNF α and IL-1 β in the heart and perivascular fibrosis, which in our experience typically indicates perivascular mast cell degranulation. 157,160,182,183”
From COVID-19, Myocarditis and Pericarditis (2023) · cites this paper as [182]
Citations
Cites
Myocarditis and inflammatory cardiomyopathy: current evidence and future directions
Tschöpe, C., Ammirati, E., Bozkurt, B., Caforio, A. L. P., Cooper, L. T., Felix, S. B., Hare, J. M., Heidecker, B., Heymans, S., Hübner, N., et al. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-020-00435-x · Cited by 1,217
Chen, L., Li, X., Chen, M., Feng, Y., & Xiong, C. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa078 · Cited by 1,163
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Research works printed but not linked: 18
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COVID-19, Myocarditis and Pericarditis
Fairweather, D., Beetler, D. J., Di Florio, D. N., Musigk, N., Heidecker, B., & Cooper, L. T. (2023) · Circulation Research · doi:10.1161/circresaha.123.321878 · Cited by 194
Metadata
- Authors
- Viveiros, A., Noyce, R. S., Gheblawi, M., Colombo, D., Bilawchuk, L. M., Clemente-Casares, X., Marchant, D. J., Kassiri, Z., Del Nonno, F., Evans, D. H., & Oudit, G. Y.
- Affiliations
- University of Alberta (CA)
- Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani (IT)
- Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada
- Pathology Unit, IRCCS Istituto Nazionale per le Malattie Infettive “Lazzaro Spallanzani”, Rome, Italy
- Corresponding author
- Oudit, Gavin Y.
- ORCID
- Venue
- American Journal of Physiology-Heart and Circulatory Physiology
- Publisher
- American Physiological Society
- Published
- 2022-12-01
- Volume
- 323
- Issue
- 6
- Pages
- H1262-H1269
- ISSN
- 0363-6135 (ISSN-L)
- 1522-1539
- PMC
- PMC9705018
- OpenAlex
- W4308769043
- Cited by
- 21
- References
- 2
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 6 · 2023: 7 · 2022: 1
- FWCI
- 2.32
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Physiology-Heart and Circulatory Physiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institute of Health Research (RES0052501)
- Topics
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Immunology Research
- Keywords
- SARS-CoV-2, COVID-19 pandemic, myocardial injury, ACE2 downregulation, cardiac inflammation, hamster model, immune cell infiltration, SARS-CoV-2 variants, viral dose
- MeSH terms
- Angiotensin-Converting Enzyme 2, COVID-19, SARS-CoV-2, Animals, Cricetinae, Humans, Infant, Inflammation, Peptidyl-Dipeptidase A
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