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Cited by 59Cardiovascular and exercise physiologyThermoregulation and physiological responsesExercise and Physiological Responses

Inhibition of α-adrenergic tone disturbs the distribution of blood flow in the exercising human limb

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Heinonen, Ilkka, Wendelin-Saarenhovi, Maria, Kaskinoro, Kimmo, Knuuti, Juhani, Scheinin, Mika, Kalliokoski, Kari K.·2013·American Journal of Physiology-Heart and Circulatory Physiology
DOI 10.1152/ajpheart.00925.2012
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Abstract

The role of neuronal regulation of human cardiovascular function remains incompletely elucidated, especially during exercise. Here we, by positron emission tomography, monitored tissue-specific blood flow (BF) changes in nine healthy young men during femoral arterial infusions of norepinephrine (NE) and phentolamine. At rest, the α-adrenoceptor agonist NE reduced BF by ~40%, similarly in muscles (from 3.2 ± 1.9 to 1.4 ± 0.3 ml·min(-1)·100 g(-1) in quadriceps femoris muscle), bone (from 1.1 ± 0.4 to 0.5 ± 0.2 ml·min(-1)·100 g(-1)) and adipose tissue (AT) (from 1.2 ± 0.7 to 0.7 ± 0.3 ml·min(-1)·100 g(-1)). During exercise, NE reduced exercising muscle BF by ~16%. BF in AT was reduced similarly as rest. The α-adrenoceptor antagonist phentolamine increased BF similarly in the different muscles and other tissues of the limb at rest. During exercise, BF in inactive muscle was increased 3.4-fold by phentolamine compared with exercise without drug, but BF in exercising muscles was not influenced. Bone and AT (P = 0.055) BF were also increased by phentolamine in the exercise condition. NE increased and phentolamine decreased oxygen extraction in the limb during exercise. We conclude that inhibition of α-adrenergic tone markedly disturbs the distribution of BF and oxygen extraction in the exercising human limb by increasing BF especially around inactive muscle fibers. Moreover, although marked functional sympatholysis also occurs during exercise, the arterial NE infusion that mimics the exaggerated sympathetic nerve activity commonly seen in patients with cardiovascular disease was still capable of directly limiting BF in the exercising leg muscles.

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  • Using positron emission tomography (PET), infusion of noradrenaline (an α-adrenoreceptor agonist) reduced adipose tissue blood flow by ≈40% both at rest during low-intensity single leg exercise.

    “using positron emission tomography (PET), it was recently demonstrated that the infusion of noradrenaline (an α-adrenoreceptor agonist) reduced adipose tissue blood flow by ≈40% both at rest during low-intensity single leg exercise [153].”

    From Regulation of Energy Substrate Metabolism in Endurance Exercise (2021) · cites this paper as [153]

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Authors
Heinonen, I., Wendelin-Saarenhovi, M., Kaskinoro, K., Knuuti, J., Scheinin, M., & Kalliokoski, K. K.
Affiliations
  • University of Turku (FI)
  • Department of Clinical Physiology and Nuclear Medicine, University of Turku and Turku University Hospital, Turku, Finland;
Corresponding author
Heinonen, Ilkka
ORCID
Venue
American Journal of Physiology-Heart and Circulatory Physiology
Publisher
American Physiological Society
Published
2013-07-15
Volume
305
Issue
2
Pages
H163-H172
ISSN
  • 0363-6135 (ISSN-L)
  • 1522-1539
DOI
10.1152/ajpheart.00925.2012
OpenAlex
W2117397676
Cited by
59
References
51
Citations by year
2026: 2 · 2025: 3 · 2024: 3 · 2023: 1 · 2022: 3 · 2021: 4 · 2020: 6 · 2019: 3 · 2018: 4 · 2017: 4 · 2016: 6 · 2015: 8 · 2014: 10 · 2013: 2
FWCI
20.51
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • American Journal of Physiology-Heart and Circulatory Physiology (publishedVersion)
  • PubMed (publishedVersion)
  • RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
Funders
  • Turun Yliopisto
  • Åbo Akademi
  • Turun Yliopistollinen Keskussairaala
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Physiology › Thermoregulation and physiological responses
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords
norepinephrine, phentolamine, tissue blood flow, limb blood flow, physical activity, quadriceps, adipose tissue, bone blood flow, oxygen extraction, sympathetic activity, functional sympatholysis
MeSH terms
Adipose Tissue, Adrenergic alpha-Agonists, Adult, Analysis of Variance, Blood Flow Velocity, Blood Vessels, Bone and Bones, Humans, Infusions, Intra-Arterial, Male, Muscle Contraction, Norepinephrine, Oxygen Consumption, Phentolamine, Regional Blood Flow, Sympathetic Nervous System, Exercise, Lower Extremity, Positron-Emission Tomography, Quadriceps Muscle, Perfusion Imaging, Young Adult

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