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Cited by 405

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

Coupling of ATP-sensitive K+ channels to A1 receptors by G proteins in rat ventricular myocytes

Kirsch, G. E., Codina, J., Birnbaumer, L., Brown, A. M.·1990·American Journal of Physiology-Heart and Circulatory Physiology
DOI 10.1152/ajpheart.1990.259.3.h820
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Abstract

ATP-sensitive K+ (K+[ATP]) current is thought to be regulated by GTP-binding proteins (G proteins), but the pathways that couple receptor, G protein, and channel have not been defined. We studied regulation of tolbutamide-sensitive K+[ATP] current in neonatal rat ventricular myocytes. Application of 0.1 mM ATP to the intracellular side of membrane patches reduced K+ [ATP] channel activity, and addition of the nonhydrolyzable GTP analogue guanosine 5'-O-(3-thiotriphosphate) (GTP gamma S) at 0.1 mM restored activity. Application of 0.1 mM intracellular GTP plus 10 microM extracellular adenosine or 100 nM N6-cyclohexyladenosine had the same effect as GTP gamma S; hence K+[ATP] channels may be coupled to adenosine receptors via G proteins. To determine which G protein, we applied G alpha subunits, preactivated with GTP gamma S to the cytoplasmic side of membrane patches, and found that alpha i1, alpha i2, and alpha i3 mimicked the effect of GTP gamma S, but not alpha o or Gs, suggesting that Gi alpha acts via a membrane-delimited pathway. Adenosine receptor coupling may be important for activating K+[ATP] channels in ischemic muscle.

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Metadata

Authors
Kirsch, G. E., Codina, J., Birnbaumer, L., & Brown, A. M.
Venue
American Journal of Physiology-Heart and Circulatory Physiology
Publisher
American Physiological Society
Published
1990-09-01
Volume
259
Issue
3
Pages
H820-H826
ISSN
  • 0363-6135 (ISSN-L)
  • 1522-1539
DOI
10.1152/ajpheart.1990.259.3.h820
OpenAlex
W1517555757
Cited by
405
References
23
FWCI
5.13
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Coupling of ATP-sensitive K+ channels to A1 receptors by G proteins in rat ventricular myocytes. https://app.cochat.ai/papers/10.1152/ajpheart.1990.259.3.h820
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Kirsch, G. E., Codina, J., Birnbaumer, L., & Brown, A. M. (1990). Coupling of ATP-sensitive K+ channels to A1 receptors by G proteins in rat ventricular myocytes. American Journal of Physiology-Heart and Circulatory Physiology. https://doi.org/10.1152/ajpheart.1990.259.3.h820

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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