The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Upregulated TRP and enhanced capacitative Ca2+entry in human pulmonary artery myocytes during proliferation
Abstract
A rise in cytosolic Ca 2+concentration ([Ca 2+]cyt) due to Ca 2+release from intracellular Ca 2+stores and Ca 2+influx through plasmalemmal Ca 2+channels plays a critical role in mitogen-mediated cell growth. Depletion of intracellular Ca 2+stores triggers capacitative Ca 2+entry (CCE), a mechanism involved in maintaining Ca 2+influx and refilling intracellular Ca 2+stores. Transient receptor potential ( TRP) genes have been demonstrated to encode the store-operated Ca 2+channels that are activated by Ca 2+store depletion. In this study, we examined whether CCE, activity of store-operated Ca 2+channels, and human TRP1 ( hTRP1) expression are essential in human pulmonary arterial smooth muscle cell (PASMC) proliferation. Chelation of extracellular Ca 2+and depletion of intracellularly stored Ca 2+inhibited PASMC growth in media containing serum and growth factors. Resting [Ca 2+]cyt as well as the increases in [Ca 2+]cyt due to Ca 2+release and CCE were all significantly greater in proliferating PASMC than in growth-arrested cells. Consistently, whole cell inward currents activated by depletion of intracellular Ca 2+stores and the mRNA level of hTRP1 were much greater in proliferating PASMC than in growth-arrested cells. These results suggest that elevated [Ca 2+]cyt and intracellularly stored [Ca 2+] play an important role in pulmonary vascular smooth muscle cell growth. CCE, potentially via hTRP1-encoded Ca 2+-permeable channels, may be an important mechanism required to maintain the elevated [Ca 2+]cyt and stored [Ca 2+] in human PASMC during proliferation.
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Cites
Hamill, O. P., Marty, A., Neher, E., Sakmann, B., & Sigworth, F. J. (1981) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00656997 · Cited by 18,436
Cited by
Store-Operated Calcium Channels
Parekh, A. B., & Putney, J. W. (2005) · Physiological Reviews · doi:10.1152/physrev.00057.2003 · Cited by 2,089
Cellular and Molecular Basis of Pulmonary Arterial Hypertension
Morrell, N. W., Adnot, S., Archer, S. L., Dupuis, J., Lloyd Jones, P., MacLean, M. R., McMurtry, I. F., Stenmark, K. R., Thistlethwaite, P. A., Weissmann, N., et al. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.04.018 · Cited by 819
Self-citationArcher, S. L., Weir, E. K., & Wilkins, M. R. (2010) · Circulation · doi:10.1161/circulationaha.108.847707 · Cited by 485
Transient Receptor Potential Channels in the Vasculature
Earley, S., & Brayden, J. E. (2015) · Physiological Reviews · doi:10.1152/physrev.00026.2014 · Cited by 420
Cell Volume Regulation in Epithelial Physiology and Cancer
Pedersen, S. F., Hoffmann, E. K., & Novak, I. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00233 · Cited by 94
Metadata
- Authors
- Golovina, V. A., Platoshyn, O., Bailey, C. L., Wang, J., Limsuwan, A., Sweeney, M., Rubin, L. J., & Yuan, J. X.-J.
- Venue
- American Journal of Physiology-Heart and Circulatory Physiology
- Publisher
- American Physiological Society
- Published
- 2001-02-01
- Volume
- 280
- Issue
- 2
- Pages
- H746-H755
- ISSN
- 0363-6135 (ISSN-L)
- 1522-1539
- OpenAlex
- W1889047426
- Cited by
- 352
- References
- 1
- FWCI
- 7.85
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Golovina, V. A., Platoshyn, O., Bailey, C. L., Wang, J., Limsuwan, A., Sweeney, M., Rubin, L. J., & Yuan, J. X.-J. (2001). Upregulated TRP and enhanced capacitative Ca2+entry in human pulmonary artery myocytes during proliferation. American Journal of Physiology-Heart and Circulatory Physiology. https://doi.org/10.1152/ajpheart.2001.280.2.h746
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