Cell Volume Regulation in Epithelial Physiology and Cancer
Open accessAbstract
The physiological function of epithelia is transport of ions, nutrients, and fluid either in secretory or absorptive direction. All of these processes are closely related to cell volume changes, which are thus an integrated part of epithelial function. Transepithelial transport and cell volume regulation both rely on the spatially and temporally coordinated function of ion channels and transporters. In healthy epithelia, specific ion channels/transporters localize to the luminal and basolateral membranes, contributing to functional epithelial polarity. In pathophysiological processes such as cancer, transepithelial and cell volume regulatory ion transport are dys-regulated. Furthermore, epithelial architecture and coordinated ion transport function are lost, cell survival/death balance is altered, and new interactions with the stroma arise, all contributing to drug resistance. Since altered expression of ion transporters and channels is now recognized as one of the hallmarks of cancer, it is timely to consider this especially for epithelia. Epithelial cells are highly proliferative and epithelial cancers, carcinomas, account for about 90% of all cancers. In this review we will focus on ion transporters and channels with key physiological functions in epithelia and known roles in the development of cancer in these tissues. Their roles in cell survival, cell cycle progression, and development of drug resistance in epithelial cancers will be discussed.
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Supra-physiological osmolarity can directly affect cell membrane tension and volume, but can also moderate how cells respond to other environmental parameters.
“Supra-physiological osmolarity can directly affect cell membrane tension and volume (Pedersen et al., 2013), but can also moderate how cells respond to other environmental parameters (Dezengotita et al., 1998).”
From Toward Best Practices for Controlling Mammalian Cell Culture Environments (2022) · cites this paper as Pedersen et al., 2013
The 'Physiology of epithelial transport and role of cell volume' section says that altered extracellular osmolarity creates osmotic gradients and discusses associated changes in cell volume. It does not specifically address supra-physiological osmolarity or state that osmolarity directly changes cell membrane tension. The later clause about responses to other environmental parameters is attributed to Dezengotita et al., not to this source. (LLM, conf=0.82)
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- Authors
- Pedersen, S. F., Hoffmann, E. K., & Novak, I.
- Affiliations
- University of Copenhagen (DK)
- Corresponding author
- Novak, Ivana
- Venue
- Frontiers in Physiology
- Publisher
- Frontiers Media SA
- Published
- 2013
- Volume
- 4
- Pages
- 233-233
- ISSN
- 1664-042X (ISSN-L)
- PMC
- PMC3757443
- OpenAlex
- W2125184213
- Cited by
- 94
- References
- 155
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 7 · 2023: 9 · 2022: 6 · 2021: 8 · 2020: 8 · 2019: 13 · 2018: 4 · 2017: 7 · 2016: 4 · 2015: 9 · 2014: 8 · 2013: 3
- FWCI
- 0.75
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Physiology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Lundbeckfonden
- Novo Nordisk
- Danmarks Frie Forskningsfond
- H. Lundbeck A/S
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- cell volume regulation, epithelial physiology, epithelial cancers, ion channels, ion transporters, transepithelial transport, epithelial polarity, drug resistance, cell survival, cell cycle progression, stromal-epithelial interactions
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