The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Comparison of tumor and normal tissue oxygen tension measurements using OxyLite or microelectrodes in rodents
Abstract
In this study we compare oxygen tension (Po 2) histograms measured with O 2 microelectrodes and a new optical Po 2 measurement device, the OxyLite, in normal tissues (mouse spleen and thymus) and in tumors (R3230Ac in rats) ( n = 5–6). The transient response to glucose infusion or 100% O 2 breathing (hyperoxia) was also measured in tumors. Po 2 histograms of spleen and thymus with the two devices were not different. The OxyLite tumor Po 2 histogram, however, was left-shifted compared with the microelectrode (median Po 2 1.0 vs. 4.0 mmHg, P = 0.016). Both probes responded to acute hyperglycemia with a mean increase of 3–6 mmHg, but the microelectrode change was not significant. The OxyLite consistently recorded large Po 2 increases (∼28 mmHg) with hyperoxia, whereas the microelectrode response was variable. The OxyLite averages Po 2 over an area that contains interstitial and vascular components, whereas the microelectrode measures a more local Po 2. This study demonstrates the importance of considering the features of the measurement device when studying tissues with heterogeneous Po 2 distributions (e.g., tumors).
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“it is noteworthy that many tissues experience low PO2 levels, even under normal physiologic conditions.”
From Hypoxia and hypoxia-inducible factors as regulators of T cell development, differentiation, and function (2013) · cites this paper as [7]
Citations
Cites
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Oxygen in Stem Cell Biology: A Critical Component of the Stem Cell Niche
Mohyeldin, A., Garzón-Muvdi, T., & Quiñones‐Hinojosa, A. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.07.007 · Cited by 1,601
Hypoxia-Induced Angiogenesis: Good and Evil
Krock, B. L., Skuli, N., & Simon, M. C. (2011) · Genes & Cancer · doi:10.1177/1947601911423654 · Cited by 1,236
Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response
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Metadata
- Authors
- Braun, R. D., Lanzen, J. L., Snyder, S. A., & Dewhirst, M. W.
- Affiliations
- Duke Medical Center (US)
- ORCID
- Dewhirst, Mark W.
- Venue
- American Journal of Physiology-Heart and Circulatory Physiology
- Publisher
- American Physiological Society
- Published
- 2001-06-01
- Volume
- 280
- Issue
- 6
- Pages
- H2533-H2544
- ISSN
- 0363-6135 (ISSN-L)
- 1522-1539
- OpenAlex
- W1842875237
- Cited by
- 285
- References
- 40
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 11 · 2023: 5 · 2022: 16 · 2021: 14 · 2020: 19 · 2019: 8 · 2018: 4 · 2017: 8 · 2016: 8 · 2015: 10 · 2014: 14 · 2013: 18 · 2012: 19
- FWCI
- 4.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Heart and Circulatory Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Physical Sciences › Chemistry › Analytical Chemistry › Analytical Chemistry and Sensors
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Keywords
- tissue oxygen tension, tumor hypoxia, oxygen microelectrodes, spleen, thymus, hyperoxia, glucose infusion
- MeSH terms
- Adenocarcinoma, Administration, Inhalation, Animals, Female, Glucose, Infusions, Intravenous, Mammary Neoplasms, Experimental, Mice, Inbred DBA, Microelectrodes, Neoplasm Transplantation, Oxygen, Partial Pressure, Polarography, Rats, Inbred F344, Spleen, Thymus Gland, Reproducibility of Results, Cell Hypoxia, Mice, Rats
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