Cited by 942Head and Neck Cancer StudiesCancer, Hypoxia, and MetabolismRadiation Therapy and Dosimetry

Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck

Nordsmark, Marianne, Overgaard, Marie, Overgaard, Jens·1996·Radiotherapy and Oncology

Abstract

Background and purpose Hypoxic tumor cells are known to be relatively radioresistant. The aim of the study was to correlate oxygenation status and radiation response in advanced squamous cell carcinomas of head and neck.Methods and patients Pretreatment oxygenation status was measured in 34 lymph nodes and one primary tumor neck using oxygen electrodes. The primary oxygenation endpoint was the fraction of pO2 values less than 2.5 mmHg. Patients received standardized, conventional, external radiotherapy 66-68 Gy in 33-34 fractions.Results Sixteen patients had loco-regional failure. Among these 16 patients the median of the fraction of pO2 values less than 2.5 mmHg was 22% (range 0-95%) as compared to 6% (range 0-51%) among patients with loco-regional tumor control. When separating all 35 patients by the median of the fraction of pO2 values less than 2.5 mmHg and comparing the 2 years actuarial tumor control probability using Kaplan-Meier estimates, the most hypoxic subgroup had significantly lower loco-regional tumor control (P = 0.013, Logrank test). By univariate regression analysis the fraction of pO2 values less than 2.5 mmHg was found to be significant as continuous variable (P = 0.010). Finally, by Cox multiple regression analysis the fraction of pO2 values less than 2.5 mmHg was found to be the strongest independent variable in predicting radiation response when using tumor control in the site of pO2 assessment as treatment endpoint (P = 0.018).Conclusion These results suggest that pretreatment tumor oxygenation status is predictive of radiation response, when using the fraction of pO2 values less than 2.5 mmHg as endpoint.

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Crossref · 10.1016/s0167-8140(96)91811-3

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Authors
Nordsmark, M., Overgaard, M., & Overgaard, J.
Affiliations
  • Danish Cancer Society (DK)
  • Aarhus University Hospital (DK)
Corresponding author
Nordsmark, Marianne
Venue
Radiotherapy and Oncology
Publisher
Elsevier BV
Published
1996-01
Volume
41
Issue
1
Pages
31-39
ISSN
0167-8140 (ISSN-L)
OpenAlex
W2087604644
Cited by
942
References
34
Citations by year
2026: 2 · 2025: 8 · 2024: 6 · 2023: 5 · 2022: 12 · 2021: 20 · 2020: 19 · 2019: 15 · 2018: 19 · 2017: 20 · 2016: 34 · 2015: 25 · 2014: 28 · 2013: 20 · 2012: 25
FWCI
57.63
Type
journal article
Language
en
Open access
closed
Locations
  • Radiotherapy and Oncology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Radiation Therapy and Dosimetry
Keywords
head and neck squamous cell carcinoma, tumor hypoxia, tumor oxygenation, radiation response, oxygen electrode, predictive biomarkers, radioresistance (biology)
MeSH terms
Carcinoma, Squamous Cell, Female, Head and Neck Neoplasms, Humans, Male, Middle Aged, Neoplasm Recurrence, Local, Radiotherapy Dosage, Radiotherapy, High-Energy, Cell Hypoxia, Proportional Hazards Models, Case-Control Studies, Treatment Outcome, Ion-Selective Electrodes

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