The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Cardiomyocyte apoptosis and ventricular remodeling after myocardial infarction in rats
Abstract
We investigated the role of cardiomyocyte apoptosis in the remodeling of the left ventricle from 24 h to 12 wk after myocardial infarction in the rat. Infarct size planimetry, quantification of cardiomyocyte apoptosis, terminal deoxynucleotide transferase-mediated dUTP nick-end labeling (TUNEL) methodology, and echocardiography (left ventricular diastolic diameter and ejection fraction) were performed. Sham-operated animals showed low rates of cardiomyocyte apoptosis (0.03%) and no change in diastolic diameter or ejection fraction during the study. Twenty-four hours after infarction, TUNEL positivity was high in the infarct areas (1.4%) and border zones (4.9%). It declined to 0.34% ( P < 0.01 vs. sham) at 4 wk and 0.10% at 12 wk in the border zones. In the remote myocardium, cardiomyocyte apoptosis increased to 0.07% ( P = 0.03 vs. sham) on day 1 and remained on the same level up to 4 wk. The increase in diastolic diameter 1–4 wk after infarction correlated ( r = 0.60, P < 0.01) with cardiomyocyte apoptosis in the noninfarcted myocardium, which quantitatively contributed most (>50%) to the apoptotic cell loss by 4 wk.
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Cites
Apoptosis in the Failing Human Heart
Olivetti, G., Abbi, R., Quaini, F., Kajstura, J., Cheng, W., Nitahara, J. A., Quaini, E., Di Loreto, C., Beltrami, C. A., Krajewski, S., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704173361603 · Cited by 1,673
Apoptosis in human acute myocardial infarction.
Saraste, A., Pulkki, K., Kallajoki, M., Henriksen, K., Parvinen, M., & Voipio-Pulkki, L.-M. (1997) · Circulation · doi:10.1161/01.cir.95.2.320 · Cited by 825 · cited 5×
“Apoptotic cardiomyocytes were detected with a terminal deoxynucleotide transferase-mediated dUTP nick-end labeling (TUNEL) assay as previously described (6, 24, 25).”
BackgroundMethodResultInfluentialSelf-citation
Cited by
Bcl-2 Engineered MSCs Inhibited Apoptosis and Improved Heart Function
Li, W., Ma, N., Ong, L.-L., Nesselmann, C., Klopsch, C., Ladilov, Y., Furlani, D., Piechaczek, C., Moebius, J. M., Lützow, K., et al. (2007) · Stem Cells · doi:10.1634/stemcells.2006-0771 · Cited by 440
Diwan, A., Krenz, M., Syed, F. M., Wansapura, J., Ren, X., Koesters, A. G., Li, H., Kirshenbaum, L. A., Hahn, H. S., Robbins, J., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32490 · Cited by 301
Apoptosis and heart failure: clinical relevance and therapeutic target
GARG, S., NARULA, J., & CHANDRASHEKHAR, Y. (2005) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2004.11.006 · Cited by 103
Apoptosis in myocardial infarction
Rodríguez, M., Lucchesi, B. R., & Schaper, J. (2002) · Annals of Medicine · doi:10.1080/078538902321012414 · Cited by 81
Yarbrough, W. M., Mukherjee, R., Escobar, G. P., Sample, J. A., McLean, J. E., Dowdy, K. B., Hendrick, J. W., Gibson, W. C., Hardin, A. E., Mingoia, J. T., et al. (2003) · The Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2003.08.012 · Cited by 25
Metadata
- Authors
- Palojoki, E., Saraste, A., Eriksson, A., Pulkki, K., Kallajoki, M., Voipio-Pulkki, L.-M., & Tikkanen, I.
- Venue
- American Journal of Physiology-Heart and Circulatory Physiology
- Publisher
- American Physiological Society
- Published
- 2001-06-01
- Volume
- 280
- Issue
- 6
- Pages
- H2726-H2731
- ISSN
- 0363-6135 (ISSN-L)
- 1522-1539
- OpenAlex
- W2159718273
- Cited by
- 300
- References
- 2
- FWCI
- 9.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- Palojoki, E., Saraste, A., Eriksson, A., Pulkki, K., Kallajoki, M., Voipio-Pulkki, L.-M., & Tikkanen, I. (2001). Cardiomyocyte apoptosis and ventricular remodeling after myocardial infarction in rats. American Journal of Physiology-Heart and Circulatory Physiology. https://doi.org/10.1152/ajpheart.2001.280.6.h2726
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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