Reduced heart size and increased myocardial fuel substrate oxidation in ACC2 mutant mice
Open accessAbstract
The cardiac-enriched isoform of acetyl-CoA carboxylase (ACC2) is a key regulator of mitochondrial fatty acid (FA) uptake via carnitine palmitoyltransferase 1 (CPT1). To test the hypothesis that oxidative metabolism is upregulated in hearts from animals lacking ACC2 (employing a transgenic Acc2-mutant mouse), we assessed cardiac function in vivo and determined rates of myocardial substrate oxidation ex vivo. When examined by echocardiography, there was no difference in systolic function, but left ventricular mass of the Acc2-mutant (MUT) mouse was significantly reduced (∼25%) compared with wild-types (WT). Reduced activation of the mammalian target of rapamycin (mTOR) and its downstream target p70S6K was found in MUT hearts. Exogenous oxidation rates of oleate were increased ∼22%, and, unexpectedly, exogenous glucose oxidation rates were also increased in MUT hearts. Using a hyperinsulinemic-euglycemic clamp, we found that glucose uptake in MUT hearts was increased by ∼83%. Myocardial triglyceride levels were significantly reduced in MUT vs. WT while glycogen content was the same. In parallel, transcript levels of PPARα and its target genes, pyruvate dehydrogenase kinase-4 (PDK-4), malonyl-CoA decarboxylase (MCD), and mCPT1, were downregulated in MUT mice. In summary, we report that 1) Acc2-mutant hearts exhibit a marked preference for the oxidation of both glucose and FAs coupled with greater utilization of endogenous fuel substrates (triglycerides), 2) attenuated mTOR signaling may result in reduced heart sizes observed in Acc2-mutant mice, and 3) Acc2-mutant hearts displayed normal functional parameters despite a significant decrease in size.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
ACC2 knockout mice demonstrate enhanced rates of fatty acid oxidation in liver and muscle.
“As indicated in Section IV.C.4, ACC2 KO mice demonstrate enhanced rates of fatty acid oxidation in liver and muscle (4, 99).”
From Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities (2010) · cites this paper as [99]
Cites
Randle, P. J., Garland, P. B., Hales, C. N., & Newsholme, E. A. (1963) · The Lancet · doi:10.1016/s0140-6736(63)91500-9 · Cited by 5,093 · see citing works
The Mitochondrial Carnitine Palmitoyltransferase System — From Concept to Molecular Analysis
McGarry, J. D., & Brown, N. F. (1997) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1997.00001.x · Cited by 1,616 · cited 1× · see citing works
“CARNITINE PALMITOYLTRANSFERASE 1 (CPT1), which catalyzes the rate-limiting step of mitochondrial fatty acid (FA) uptake, is subject to stringent regulatory mechanisms (24).”
BackgroundLipotoxic heart disease in obese rats: Implications for human obesity
Zhou, Y.-T., Grayburn, P., Karim, A., Shimabukuro, M., Higa, M., Baetens, D., Orci, L., & Unger, R. H. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.4.1784 · Cited by 1,265 · see citing works
RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1
Burnett, P. E., Barrow, R. K., Cohen, N. A., Snyder, S. H., & Sabatini, D. M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.4.1432 · Cited by 1,139 · see citing works
Phosphatidic Acid-Mediated Mitogenic Activation of mTOR Signaling
Fang, Y., Vilella-Bach, M., Bachmann, R., Flanigan, A., & Chen, J. (2001) · Science · doi:10.1126/science.1066015 · Cited by 1,055 · see citing works
Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2
Abu-Elheiga, L., Matzuk, M. M., Abo-Hashema, K. A. H., & Wakil, S. J. (2001) · Science · doi:10.1126/science.1056843 · Cited by 903 · see citing works
Self-citation[7] Chemical procedures for analysis of polysaccharides
Hassid, W. Z., & Abraham, S. (1957) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(57)03345-5 · Cited by 712 · see citing works
McGarry, J. D., Mills, S. E., Long, C. S., & Foster, D. W. (1983) · Biochemical Journal · doi:10.1042/bj2140021 · Cited by 556 · see citing works
Regulation of fatty acid oxidation in the mammalian heart in health and disease
Lopaschuk, G. D., Belke, D. D., Gamble, J., Toshiyuki, I., & Schönekess, B. O. (1994) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(94)00082-4 · Cited by 555 · see citing works
The subcellular localization of acetyl-CoA carboxylase 2
Abu-Elheiga, L. A., Brinkley, W. R., Zhong, L., Chirala, S. S., Woldegiorgis, G., & Wakil, S. J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.4.1444 · Cited by 450 · see citing works
Self-citationBing, R. J., Siegel, A., Ungar, I., & Gilbert, M. (1954) · The American Journal of Medicine · doi:10.1016/0002-9343(54)90365-4 · Cited by 442 · see citing works
Unloaded heart in vivo replicates fetal gene expression of cardiac hypertrophy
Depré, C., Shipley, G. L., Chen, W., Han, Q., Doenst, T., Moore, M. L. G., Stepkowski, S. M., Davies, P. J., & Taegtmeyer, H. (1998) · Nature Medicine · doi:10.1038/3253 · Cited by 423 · see citing works
Self-citationOxidative Capacity, Lipotoxicity, and Mitochondrial Damage in Type 2 Diabetes
Schrauwen, P., & Hesselink, M. K. C. (2004) · Diabetes · doi:10.2337/diabetes.53.6.1412 · Cited by 408 · see citing works
Abu-Elheiga, L., Oh, W., Kordari, P., & Wakil, S. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1733877100 · Cited by 389 · see citing works
Self-citationHypertrophic Cardiomyopathy in Cardiac Myosin Binding Protein-C Knockout Mice
Harris, S. P., Bartley, C. R., Hacker, T. A., McDonald, K. S., Douglas, P. S., Greaser, M. L., Powers, P. A., & Moss, R. L. (2002) · Circulation Research · doi:10.1161/01.res.0000012222.70819.64 · Cited by 383 · see citing works
Peterson, R., Beal, P., Comb, M., & Schreiber, S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.10.7416 · Cited by 355 · see citing works
Choi, C. S., Savage, D. B., Abu-Elheiga, L., Liu, Z.-X., Kim, S., Kulkarni, A., Distefano, A., Hwang, Y.-J., Reznick, R. M., Codella, R., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706794104 · Cited by 325 · see citing works
Self-citationRegulation of Energy Metabolism of the Heart during Acute Increase in Heart Work
Goodwin, G. W., Taylor, C. S., & Taegtmeyer, H. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.45.29530 · Cited by 323 · see citing works
Self-citationMyocardial metabolism of free fatty acids. Studies with 14C-labeled substrates in humans.
Wisneski, J. A., Gertz, E. W., Neese, R. A., & Mayr, M. (1987) · Journal of Clinical Investigation · doi:10.1172/jci112820 · Cited by 286 · see citing works
Mutant mice lacking acetyl-CoA carboxylase 1 are embryonically lethal
Abu-Elheiga, L. A., Matzuk, M. M., Kordari, P., Oh, W. K., Shaiken, T. E., Gu, Z., & Wakil, S. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505714102 · Cited by 263 · see citing works
Self-citationIdentification of an isozymic form of acetyl-CoA carboxylase.
Bianchi, A., Evans, J. L., Iverson, A. J., Nordlund, A. C., Watts, T. D., & Witters, L. A. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)40045-8 · Cited by 261 · see citing works
Increased Myocardial Oxygen Consumption Reduces Cardiac Efficiency in Diabetic Mice
How, O.-J., Aasum, E., Severson, D. L., Chan, W. Y. A., Essop, M. F., & Larsen, T. S. (2006) · Diabetes · doi:10.2337/diabetes.55.02.06.db05-1164 · Cited by 248 · see citing works
Self-citationThe diabetic heart: metabolic causes for the development of a cardiomyopathy
Rodrigues, B. B., & McNeill, J. H. (1992) · Cardiovascular Research · doi:10.1093/cvr/26.10.913 · Cited by 225 · see citing works
Young, M. E., Patil, S. U., Ying, J., Depré, C., Ahuja, H. S., Shipley, G. L., Stepkowski, S. M., Davies, P. J., & Taegtmeyer, H. (2001) · The FASEB Journal · doi:10.1096/fj.00-0351com · Cited by 223 · see citing works
Self-citationHuman Acetyl-CoA Carboxylase 2
Abu-Elheiga, L. A., Almarza-Ortega, D. B., Baldini, A., & Wakil, S. J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.16.10669 · Cited by 221 · see citing works
Self-citationIntrinsic Diurnal Variations in Cardiac Metabolism and Contractile Function
Young, M. E., Razeghi, P., Cedars, A. M., Guthrie, P. H., & Taegtmeyer, H. (2001) · Circulation Research · doi:10.1161/hh2401.100741 · Cited by 204 · see citing works
Self-citationHuman acetyl-CoA carboxylase: characterization, molecular cloning, and evidence for two isoforms.
Abu-Elheiga, L. A., Jayakumar, A., Baldini, A., Chirala, S. S., & Wakil, S. J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.9.4011 · Cited by 189 · see citing works
Self-citationMcGarry, J., Stark, M. J., & Foster, D. W. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34394-6 · Cited by 188 · see citing works
Chandler, C. E., Wilder, D. E., Pettini, J. L., Savoy, Y. E., Petras, S. F., Chang, G., Vincent, J., & Harwood, H. J. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m300094-jlr200 · Cited by 177 · see citing works
Samuel, V. T., Choi, C. S., Phillips, T. G., Romanelli, A. J., Geisler, J. G., Bhanot, S., McKay, R. A., Monia, B. P., Shutter, J. R., Lindberg, R. A., et al. (2006) · Diabetes · doi:10.2337/db05-0705 · Cited by 177 · see citing works
Self-citationStructure of the coding sequence and primary amino acid sequence of acetyl-coenzyme A carboxylase.
López‐Casillas, F., Bai, D. H., Luo, X. C., Kong, I., Hermodson, M. A., & Kim, K. H. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.16.5784 · Cited by 171 · see citing works
Dyck, J. R. B., Hopkins, T. A., Bonnet, S., Michelakis, E. D., Young, M. E., Watanabe, M., Kawase, Y., Jishage, K., & Lopaschuk, G. D. (2006) · Circulation · doi:10.1161/circulationaha.106.642009 · Cited by 157 · see citing works
Formation of malonyl coenzyme A in rat heart
Thampy, K. G. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)84614-8 · Cited by 153 · see citing works
SAGGERSON, E. D., & Carpenter, C. A. (1981) · FEBS Letters · doi:10.1016/0014-5793(81)80171-8 · Cited by 146 · see citing works
Debard, C., Laville, M., Berbe, V., Loizon, E., Guillet, C., Morio, B., Boirie, Y., & Vidal, H. (2004) · Diabetologia · doi:10.1007/s00125-004-1394-7 · Cited by 145 · see citing works
Glucose and fat metabolism in adipose tissue of acetyl-CoA carboxylase 2 knockout mice
Oh, W. K., Abu-Elheiga, L. A., Kordari, P., Gu, Z.-W., Shaiken, T. E., Chirala, S. S., & Wakil, S. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409451102 · Cited by 139 · see citing works
Self-citationPrimary structure of chicken liver acetyl-CoA carboxylase deduced from cDNA sequence.
Takai, T., Yokoyama, C., Wada, K., & Tanabe, T. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)69116-1 · Cited by 115 · see citing works
Abnormal mechanical function in diabetes
Lopaschuk, G. D. (1996) · Coronary Artery Disease · doi:10.1097/00019501-199602000-00004 · Cited by 87 · see citing works
Evaluation of left ventricular diastolic function by pulsed Doppler tissue imaging in mice
Schaefer, A., Klein, G., Brand, B., Lippolt, P., Drexler, H., & Meyer, G. P. (2003) · Journal of the American Society of Echocardiography · doi:10.1067/s0894-7317(03)00679-5 · Cited by 73 · see citing works
Youn, J. H., & Buchanan, T. A. (1993) · Diabetes · doi:10.2337/diab.42.5.757 · Cited by 64 · see citing works
Arvisais, E. W., Romanelli, A., Hou, X., & Davis, J. S. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605371200 · Cited by 62 · see citing works
Ménage-à-Trois 1 Is Critical for the Transcriptional Function of PPARγ Coactivator 1
Sano, M., Izumi, Y., Helenius, K. P., Asakura, M., Rossi, D. J., Xie, M., Taffet, G. E., Hu, L., Pautler, R. G., Wilson, C. R., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.01.003 · Cited by 62 · see citing works
Self-citationヒトアセチルCoAカルボキシラーゼ 特性化,分子クローニングおよび2つのイソフォームの証拠
Abu-Elheiga, L. A., Jayakumar, A., Baldini, A., Chirala, S. S., & Wakil, S. J. (1995) · Cited by 56 · see citing works
Self-citationTsujita, Y., Katō, T., & Sussman, M. A. (2005) · Echocardiography · doi:10.1111/j.0742-2822.2005.04014.x · Cited by 27 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Myocardial Fatty Acid Metabolism in Health and Disease
Lopaschuk, G. D., Ussher, J. R., Folmes, C. D. L., Jaswal, J. S., & Stanley, W. C. (2010) · Physiological Reviews · doi:10.1152/physrev.00015.2009 · Cited by 2,180 · see citing works
Fatty acid metabolism: Target for metabolic syndrome
Wakil, S. J., & Abu-Elheiga, L. A. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r800079-jlr200 · Cited by 731 · see citing works
Self-citationSivitz, W. I., & Yorek, M. A. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2531 · Cited by 742 · see citing works
The randle cycle revisited: a new head for an old hat.
Hue, L., & Taegtmeyer, H. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00093.2009 · Cited by 743 · see citing works
Self-citationStructure and function of biotin-dependent carboxylases
Tong, L. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1096-0 · Cited by 473 · see citing works
Lipid Use and Misuse by the Heart
Schulze, P. C., Drosatos, K., & Goldberg, I. J. (2016) · Circulation Research · doi:10.1161/circresaha.116.306842 · Cited by 358 · see citing works
Metabolism in cardiomyopathy: every substrate matters
Ritterhoff, J., & Tian, R. (2017) · Cardiovascular Research · doi:10.1093/cvr/cvx017 · Cited by 309 · see citing works
Kolwicz, S. C., Olson, D. P., Marney, L. C., Garcia‐Menendez, L., Synovec, R. E., & Tian, R. (2012) · Circulation Research · doi:10.1161/circresaha.112.268128 · Cited by 284 · see citing works
Cardiac Lipotoxicity: Molecular Pathways and Therapeutic Implications
Drosatos, K., & Schulze, P. C. (2013) · Current Heart Failure Reports · doi:10.1007/s11897-013-0133-0 · Cited by 217 · see citing works
Acetyl-CoA Carboxylases and Diseases
Wang, Y., Yu, W., Li, S., Guo, D., He, J., & Wang, Y. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.836058 · Cited by 225 · see citing works
Ellis, J. M., Mentock, S. M., DePetrillo, M. A., Koves, T. R., Sen, S., Watkins, S. M., Muoio, D. M., Cline, G. W., Taegtmeyer, H., Shulman, G. I., et al. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.01085-10 · Cited by 194 · see citing works
Self-citationSGLT2 inhibitors: role in protective reprogramming of cardiac nutrient transport and metabolism
Packer, M. (2023) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00824-4 · Cited by 190 · see citing works
Ussher, J. R., Koves, T. R., Jaswal, J. S., Zhang, L., Ilkayeva, O., Dyck, J. R. B., Muoio, D. M., & Lopaschuk, G. D. (2009) · Diabetes · doi:10.2337/db09-0011 · Cited by 135 · see citing works
Gene knockout of Acc2 has little effect on body weight, fat mass, or food intake
Olson, D. P., Pulinilkunnil, T., Cline, G. W., Shulman, G. I., & Lowell, B. B. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913492107 · Cited by 109 · see citing works
Self-citationAbu-Elheiga, L. A., Wu, H., Gu, Z., BRESSLER, R. C., & Wakil, S. J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.309559 · Cited by 84 · see citing works
Self-citationUssher, J. R., & Lopaschuk, G. D. (2009) · Basic Research in Cardiology · doi:10.1007/s00395-009-0003-9 · Cited by 67 · see citing works
van Weeghel, M., Abdurrachim, D., Nederlof, R., Argmann, C., Houtkooper, R. H., Hagen, J., Nabben, M., Denis, S. W., Čiapaitė, J., Kolwicz, S. C., et al. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvy089 · Cited by 53 · see citing works
The role of triacylglycerol in cardiac energy provision
Evans, R. D., & Hauton, D. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.03.010 · Cited by 35 · see citing works
Cardiac Metabolism in Perspective
Taegtmeyer, H., Lam, T., & Davogustto, G. (2016) · Comprehensive physiology · doi:10.1002/cphy.c150056 · Cited by 38 · see citing works
Self-citationIntegrated Control of Fatty Acid Metabolism in Heart Failure
Li, X., & Bi, X. (2023) · Metabolites · doi:10.3390/metabo13050615 · Cited by 33 · see citing works
Pasqua, T., Rocca, C., Giglio, A., & Angelone, T. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10040721 · Cited by 31 · see citing works
Malonyl CoA: A promising target for the treatment of cardiac disease
Fillmore, N., & Lopaschuk, G. D. (2014) · IUBMB Life · doi:10.1002/iub.1253 · Cited by 30 · see citing works
Marjanovic, J., Chalupská, D., Patenode, C., de Coster, A., Arnold, E. M., Ye, A. L., Anesi, G. L., Lu, Y., Okun, I. M., Tkachenko, S. N., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003721107 · Cited by 29 · see citing works
Enhancing fatty acid oxidation negatively regulates PPARs signaling in the heart
Liu, Z., Ding, J., McMillen, T. S., Villet, O. M., Tian, R., & Shao, D. (2020) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2020.06.008 · Cited by 20 · see citing works
Liquid-liquid extraction coupled with LC/MS/MS for monitoring of malonyl-CoA in rat brain tissue
Onorato, J. M., Chen, L., Shipkova, P. A., Ma, Z., Azzara, A. V., Devenny, J. J., Liang, N., Haque, T. S., & Cheng, D. (2010) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-010-3879-1 · Cited by 18 · see citing works
Anavi, S., Ilan, E., Tirosh, O., & Madar, Z. (2010) · Obesity · doi:10.1038/oby.2009.489 · Cited by 17 · see citing works
Adam, T., Opie, L. H., & Essop, M. F. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.06.106 · Cited by 15 · see citing works
Self-citationPressure Overload Impairs Cardiac Function in Long-Chain Fatty Acid Transporter CD36-Knockout Mice
Nakatani, K., Masuda, D., Kobayashi, T., Sairyo, M., Zhu, Y., Okada, T., Naito, A. T., Ohama, T., Koseki, M., Oka, T., et al. (2018) · International Heart Journal · doi:10.1536/ihj.18-114 · Cited by 13 · see citing works
Cardiac Metabolism in Perspective
Taegtmeyer, H., Lam, T., & Davogustto, G. (2016) · Comprehensive physiology · doi:10.1002/j.2040-4603.2016.tb00728.x · Cited by 6 · see citing works
Self-citationKim, C.-W., do Vale, G. D., Fu, X., McDonald, J. G., Dai, C., Li, C., Wang, Z. V., Sharma, G., Khemtong, C., Malloy, C. R., et al. (2026) · Journal of Clinical Investigation · doi:10.1172/jci202528 · Cited by 4 · see citing works
DEMİRCAN, A., Coşkunpınar, E. M., Demirci, D. K., Özkara, G., Yanar, F., Gömleksiz, Ö. K., Buğra, Z., Öztürk, O., & Yılmaz, H. (2019) · Turkish Journal of Biochemistry · doi:10.1515/tjb-2018-0546 · Cited by 3 · see citing works
Genome-wide transcript and protein analysis reveals distinct features of aging in the mouse heartPreprint
Gyuricza, I. G., Chick, J. M., Keele, G. R., Deighan, A. G., Munger, S. C., Korstanje, R., Gygi, S. P., & Churchill, G. A. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.08.28.272260 · Cited by 2 · see citing works
Effects of cellular lipids on heart in pathology and physiology
Balatskyi, V. V., Wołosiewicz, M., Dobosz, A. M., Tracz‐Gaszewska, Z., Sówka, A., Kendziorek, M., Krogulec, E., Navrulin, V. O., & Dobrzyń, P. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-95582-9.00003-6 · Cited by 1 · see citing works
Smith, W. T. (2012) · SUNScholar (Stellenbosch University)
On Glucose Metabolism in Patients with the m.3243A>G Mutation
Lindroos, M. M. (2013) · UTUPub (University of Turku)
Alrob, O. A. (2018) · Jordan Journal of Pharmaceutical Sciences
Metabolic Modulation in Heart Disease
Sidhu, V. K. (2013) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3c03d
Dhanyalayam, D., Lizardo, K., Oswal, N., Thangavel, H., Dolgov, E., Perlin, D. S., & Nagajyothi, J. F. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.09.18.460895
Integration of multiple perspectives to understand the left ventricular pressure–volume relationship
Tonti, G., Pedrizzetti, G., & Salustri, A. (2026) · Communications Medicine · doi:10.1038/s43856-026-01901-2
Maarman, G. J. (2010) · SUNScholar (Stellenbosch University)
- Authors
- Essop, M. F., Camp, H. S., Choi, C. S., Sharma, S., Fryer, R. M., Reinhart, G. A., Guthrie, P. H., Bentebibel, A., Gu, Z., Shulman, G. I., Taegtmeyer, H., Wakil, S. J., & Abu-Elheiga, L.
- Affiliations
- Stellenbosch University (ZA)
- Abbott (United States) (US)
- Yale University (US)
- The University of Texas Health Science Center at Houston (US)
- Baylor College of Medicine (US)
- ORCID
- Venue
- American Journal of Physiology-Heart and Circulatory Physiology
- Publisher
- American Physiological Society
- Published
- 2008-07
- Volume
- 295
- Issue
- 1
- Pages
- H256-H265
- ISSN
- 0363-6135 (ISSN-L)
- 1522-1539
- PMC
- PMC2494759
- OpenAlex
- W2131194003
- Cited by
- 40
- References
- 44
- Citations by year
- 2026: 2 · 2023: 3 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 1 · 2016: 4 · 2014: 1 · 2013: 3 · 2012: 4
- FWCI
- 3.15
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Physiology-Heart and Circulatory Physiology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Warwick Medical School
- National Heart, Lung, and Blood Institute (T32HL007591, R01-HL-073162-01, R01HL073162, T32-HL 07591)
- National Institute of General Medical Sciences (GM 63115, R01GM063115)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01-DK40936, U24DK76169, R01DK040936, U24DK059635, U24DK076169)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- acetyl-CoA carboxylase 2, cardiac fatty acid oxidation, glucose oxidation, mTOR signaling, p70S6K, left ventricular mass, cardiac hypertrophy, carnitine palmitoyltransferase 1, PPARα, PDK4, malonyl-CoA decarboxylase, myocardial triglycerides, myocardial glucose uptake
- MeSH terms
- Pyruvate Dehydrogenase Acetyl-Transferring Kinase, Acetyl-CoA Carboxylase, Animals, Carboxy-Lyases, Carnitine O-Palmitoyltransferase, Energy Metabolism, Glucose, Glycogen, Heart Ventricles, Male, Mice, Inbred C57BL, Mice, Transgenic, Mutation, Myocardium, Organ Size, Oxidation-Reduction, Protein Kinases, Time Factors, Triglycerides, Ultrasonography, Glucose Clamp Technique, Down-Regulation, Protein Serine-Threonine Kinases, Oleic Acid, Ribosomal Protein S6 Kinases, 70-kDa, PPAR gamma, Mice, TOR Serine-Threonine Kinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
