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Urges to eat and drink in rats.
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“when animals are fed nutrients in varying dilutions, they adjust their intake to maintain constancy of the number of calories that are consumed, not the volume (12).”
From Leptin at 14 y of age: an ongoing story (2009) · cites this paper as [12]
In the citing paper
“All these data suggested that there must be a biological system that regulates food intake and maintains homeostatic control of body weight (12).”
From Leptin at 14 y of age: an ongoing story (2009) · cites this paper as [12]
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Absence of post-fast food compensation in the golden hamster (Mesocricetus auratus)☆☆☆
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Obesity: Understanding and treating a serious, prevalent, and refractory disorder.
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“Over the course of a few meals, however, they abandon mouth cues and stomach volume and shift to more proximal signals, consuming enough bulk to get the customary calories (Adolph, 1947).”
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“Because rats can regulate energy balance and typically consume the appropriate amount of calories to sustain optimal body mass [78,79], it is not surprising that rats with wheel access may ingest slightly more calories [37].”
BackgroundTHE ECONOMICS OF DAILY CONSUMPTION CONTROLLING FOOD‐ AND WATER‐REINFORCED RESPONDING1
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Motivation, regulation, and the control of meal parameters with oral and intragastric feeding.
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Feeding patterns of rats in response to fasts and changes in environmental conditions
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Caloric regulation in normal-weight men maintained on a palatable diet of concentional foods☆
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Leptin and the Regulation of Body Weigh
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SPECIES DIFFERENCES IN THE INTERACTION OF FEEDING AND DRINKING*
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Effects of equicaloric loads of protein, fat, and carbohydrate on food intake in the rat and man
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NEURAL REGULATION OF FOOD INTAKE
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“These results contrast findings in rats, which are known to compensate for dehydration-induced body weight loss by markedly increasing food intake during the subsequent rehydration (1).”
ResultPROBLEMS OF REFEEDING AFTER STARVATION IN THE RAT*
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“In 1947 E. Adolph systematically manipulated the energy density of diets given to adult rats and, upon observing their adaptive consummatory responses, readily concluded that ‘within limits, rats eat for calories’ (Adolph, 1947).”
BackgroundInfluentialNixon, J. P., Zhang, M., Wang, C., Kuskowski, M. A., Novak, C. M., Levine, J. A., Billington, C. J., & Kotz, C. M. (2010) · Obesity · doi:10.1038/oby.2009.471 · Cited by 115
“The change in fat mass during and after water deprivation is likely due to the concurrent reduction in food intake observed in waterdeprived rats (22).”
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Physiology of the Control of Food Intake
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Caloric regulation of food intake in man.
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Increased efficiency of food utilization following weight loss
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“In contrast, the theory of physiological regulation proposes that intake is the result of the animal eating to meet its physiological needs (1, 39, 46).”
BackgroundHuman eating behaviour in an evolutionary ecological context
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“2 shows feedback relationships between animal physiology and genotype, food and environment that underpin the ‘eating to meet requirements subject to constraints’ theory first put forward by Adolph (1947) and modified by Emmans & Oldham (1988).”
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“Therefore, increasing the caloric content of food should steepen the late-session decrease in responding for calorie-regulating animals, such as rats or humans (Adolph, 1947; Hausmann, 1933).”
BackgroundBODY WEIGHT LOSS AS A MEASURE OF MOTIVATION IN HUNGER AND THIRST*
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“An animal deprived of food or water does two things: He loses weight and he becomes more active. Many studies have shown an intimate relation between these two classes of events (cf. Bolles, 1967). The premise of this paper is that further study of this relation may add to the knowledge of the underlying physiological…”
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Studies of Food-Intake Regulation in Man
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Food quotient, respiratory quotient, and energy balance
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“serve energy balance is reported in a seminal paper by Adolph [2] showing that rats subjected to dilution of their diet during a period of several weeks with a non-caloric substance responded with an appropriate increase in food intake essentially rendering their energy balance undisturbed.”
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“The animals drink less overall and it is normal in mammals for water deprivation to lead to a ‘voluntary’ reduction in food intake (Adolph, 1947; Bolles, 1961; Finger and Reid, 1952; Cizek and Nocenti, 1965; Collier and Levitsky, 1967; Kutscher, 1969; Engell, 1988).”
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Metadata
- Authors
- Adolph, E. F.
- Affiliations
- University of Rochester Medicine (US)
- Corresponding author
- Adolph, Edward F.
- Venue
- American Journal of Physiology-Legacy Content
- Publisher
- American Physiological Society
- Published
- 1947-10-31
- Volume
- 151
- Issue
- 1
- Pages
- 110-125
- ISSN
- 0002-9513 (ISSN-L)
- OpenAlex
- W2186443013
- Cited by
- 449
- References
- 0
- Citations by year
- 2026: 2 · 2025: 5 · 2023: 3 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 3 · 2016: 3 · 2015: 6 · 2014: 3 · 2013: 5 · 2012: 5
- FWCI
- 8.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Legacy Content (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Keywords
- appetite, dietary intake, thirst, drinking behavior, rats
- MeSH terms
- Animals, Food, Rats
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