Cited by 463Drug Transport and Resistance MechanismsBarrier Structure and Function StudiesAmino Acid Enzymes and Metabolism

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Carrier-mediated blood-brain barrier transport of short-chain monocarboxylic organic acids

Oldendorf, WH·1973·American Journal of Physiology-Legacy Content

DOI 10.1152/ajplegacy.1973.224.6.1450

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“A previous study shows that 14 C-SCFAs are detected in rat brains after carotid artery injection [25].”
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“The brain uptake of SCFAs, including butyrate, after parenteral administration in rats, was demonstrated long ago [89], but even more significant data are those indicating the higher concentration of Fig.”
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“However, others have documented that the blood–brain barrier is permeable to lactate (Dalsgaard et al., 2004, Smith et al., 2003 and Oldendorf, 1973) and the lactate transporter MCT1 is expressed on endothelial cells (Gerhart et al., 1997).”
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“…might be transported by the same mitochondrial membrane protein carrier (monocarboxylic transporter) as used by pyruvate (formed from glucose) and acetate (Oldendorf 1973), competition between these substrates for this transporter could explain our results of reduced CO2 generation from acetate.”
Method
Gut microbiota metabolites: potential therapeutic targets for Alzheimer’s disease?
Zhang, S., Lu, J., Jin, Z., Xu, H., Zhang, D., Chen, J., & Wang, J. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1459655 · Cited by 25
“Oldendorf and coworkers found in 1973 that acetate, propionate, and butyrate, which are SCFAs, are able to pass through the BBB in rats after being injected with labeled SCFAs (Oldendorf, 1973).”
Background
Disturbance of energy and redox homeostasis and reduction of Na+,K+-ATPase activity provoked by in vivo intracerebral administration of ethylmalonic acid to young rats
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The Effect of Combined Hypoxemia and Cephalic Hypotension on Fetal Cerebral Blood Flow and Metabolism
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[1-14C]Octanoate: a fast functional marker of brain activity
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In-vitro Evidence for Carrier-mediated Uptake of Acidic Drugs by Isolated Bovine Brain Capillaries
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Diabetic chronic hyperglycemia and cerebral pH recovery following global ischemia in dogs.
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The Ammonium-Induced Increase in Rat Brain Lactate Concentration is Rapid and Reversible and is Compatible with Trafficking and Signaling Roles for Ammonium
Provent, P., Kickler, N., Barbier, E., Bergerot, A., Farion, R., Goury, S., Marcaggi, P., Segebarth, C. M., & Coles, J. A. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600480 · Cited by 16
“Acetate is taken up into brain and metabolized (Gonda and Quastel, 1966; Oldendorf, 1973), so it will change some metabolite concentrations; we therefore used Cl as anion.”
Method
Phosphate transport by capillaries of the blood-brain barrier.
Dallaire, L., & Béliveau, R. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41673-0 · Cited by 16
Permeability: Blood–Brain Barrier
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Anion transport in red blood cells
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Metabolic products of [2‐13C]ethanol in the rat brain after chronic ethanol exposure
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“Metabolic fate of EtOH-derived 13C acetate Acetate crosses the blood–brain barrier (BBB) more slowly than does glucose (Deelchand et al. 2009; Oldendorf 1973; Patel et al. 2010) and is metabolized exclusively by astroglia (Fig.”
Background
Inhibition of in vitro CO2 production and lipid synthesis by 2-hydroxybutyric acid in rat brain
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“A competition of 2hydroxybutyric acid with acetate for the same monocarboxylic membrane transporter could occur (16,17), reducing the availability of the labeled substrate (acetate) to produce (14)CO2 and lipids.”
Background
Phosphate Transport in Capillaries of the Blood-Brain Barrier
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Actions of ethanol and acetate on rat cortical neurons: Ethanol/adenosine interactions
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An Intravenous Technique for the Measurement of Cerebral Vascular Extraction Fraction in the Rat
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Uptake and hydrolysis of glycylglutamine at the blood-brain barrier
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Potassium transport in isolated cerebral microvessels from the rat.
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L(+)-Lactate binding to preparations of rat hepatocyte plasma membranes.
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l-Carnitine: therapeutic strategy for metabolic encephalopathy
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Pyruvate Prevents Dopaminergic Neurodegeneration and Motor Deficits in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Model of Parkinson’s Disease
Kim, Y., Choi, S. Y., Hwang, O., & Lee, J. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-03017-9 · Cited by 14
“As a primary intermediate substrate to direct intracellular energy metabolism, pyruvate is the cytosolic product of glycolysis, or it can be imported from the blood into glial cells or neurons [43, 78, 85, 86] via monocarboxylate transporters (MCTs) [87, 88].”
Background

Authors: Oldendorf, W.
Corresponding author: Oldendorf, WH
Venue: American Journal of Physiology-Legacy Content
Publisher: American Physiological Society
Published: 1973-06-01
Volume: 224
Issue: 6
Pages: 1450-1453
ISSN: 0002-9513 (ISSN-L)
DOI: 10.1152/ajplegacy.1973.224.6.1450
OpenAlex: W2294335852
Cited by: 463
References: 0
Citations by year: 2026: 16 · 2025: 17 · 2024: 21 · 2023: 20 · 2022: 32 · 2021: 13 · 2020: 7 · 2019: 5 · 2018: 9 · 2017: 2 · 2016: 9 · 2015: 4 · 2014: 4 · 2013: 9 · 2012: 6
FWCI: 4.23
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Legacy Content (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
Keywords: blood-brain barrier, carrier-mediated transport, organic acids, brain uptake, monocarboxylate transporters
MeSH terms: Acetates, Amino Acids, Animals, Biological Transport, Blood-Brain Barrier, Brain, Butyrates, Carbon Isotopes, Carboxylic Acids, Dicarboxylic Acids, Female, Glucose, Lactates, Male, Propionates, Pyruvates, Tricarboxylic Acids, Tritium, Rats

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Carrier-mediated blood-brain barrier transport of short-chain monocarboxylic organic acids

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