The DOI matches its Crossref record.
Carrier-mediated blood-brain barrier transport of short-chain monocarboxylic organic acids
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The abundant expression of MCTs in endothelial cells (75, 92) might facilitate crossing of the BBB by SCFAs since brain uptake of SCFAs has previously been demonstrated in rats following injection of 14C-SCFAs into the carotid artery (93).”
From The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication (2020) · cites this paper as [93]
In the citing paper
“A small fraction reaches the systemic circulation and can cross the tightly regulated BBB using their own transporters located on brain vascular epithelial cells (100, 101).”
From The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology (2020) · cites this paper as [100]
Citations
Cited by
Sorted by citations
Items 301–400 of 461
Giannos, P., Prokopidis, K., Lidoriki, I., Triantafyllidis, K. K., Kechagias, K. S., Celoch, K., Candow, D. G., Ostojić, S. M., & Forbes, S. C. (2022) · BMC Geriatrics · doi:10.1186/s12877-022-03521-6 · Cited by 14
“Both C8 and C10 can cross the blood brain barrier [34, 35].”
BackgroundTreatment of Essential Tremor with Long-Chain Alcohols: Still Experimental or Ready for Prime Time?
Haubenberger, D., Nahab, F. B., Voller, B., & Hallett, M. (2013) · Europe PMC (PubMed Central) · doi:10.7916/d82r3ppm · Cited by 15
Monographs on fragrance raw materials
Opdyke, D. L. J. (1981) · Food and Cosmetics Toxicology · doi:10.1016/0015-6264(81)90311-4 · Cited by 14
Small molecular drug transfer across the blood-brain barrier via carrier-mediated transport systems
Tsuji, A. (2005) · Neurotherapeutics · doi:10.1007/bf03206642 · Cited by 14
Kim, T. S., Roe, C. R., Mann, J. D., & Breese, G. R. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb11370.x · Cited by 13
Mechanism of valproic acid uptake by isolated rat brain microvessels
Naora, K., & Shen, D. D. (1995) · Epilepsy Research · doi:10.1016/0920-1211(95)00034-8 · Cited by 14
“Oldendorf [26] provided the first evidence for a carrier-mediated transport of short-chain (C2-C5) fatty acids and lactic acid at the blood-brain barrier.”
BackgroundSynthesis and preliminary evaluation of [1-11C]hexanoate as a PET tracer of fatty acid metabolism
Ishiwata, K., Ishii, K., Ogawa, K., et al. (1995) · Annals of Nuclear Medicine · doi:10.1007/bf03165010 · Cited by 14
Riva, C. E., Alm, A., & Pournaras, C. J. (2011) · Elsevier eBooks · doi:10.1016/b978-0-323-05714-1.00010-8 · Cited by 20
Inhibition of Rat Brain Lipid Synthesis In Vitro by 4-Hydroxybutyric Acid
Silva, A. R., Ruschel, C. F. C., Helegda, C., et al. (1999) · Metabolic Brain Disease · doi:10.1023/a:1020658624567 · Cited by 13
“4HB, like acetate, is a monocarboxylic acid, so they may compete for the same monocarboxylic membrane carrier (Oldendorf, 1973; Poole and Halestrap, 1993) and therefore reduce the availability of the labeled substrate (acetate) to produce (14)CO2.”
BackgroundPermeability of the Blood-Brain Barrier to Circulating Free Fatty Acids
Banks, W. A., Kastin, A. J., & Rapoport, S. I. (1997) · Humana Press eBooks · doi:10.1007/978-1-4757-2582-7_1 · Cited by 13
Yuwiler, A., Bennett, B. L., & Geller, E. (1982) · Neurochemical Research · doi:10.1007/bf00965898 · Cited by 13
Morris, A. A. M. (2006) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-006-9998-3 · Cited by 13
“Whereas methylmalonate is a DCA, propionate is a monocarboxylic acid and it is carried across the blood–brain barrier by the monocarboxylic acid transporter (MCT1) (Oldendorf 1973).”
BackgroundBlood-Brain Barrier: Techniques for the Intracerebral Administration of Drugs
MYERS, R. D. (1975) · Springer eBooks · doi:10.1007/978-1-4684-3168-1_1 · Cited by 13
Khoo, S. C., Zhang, N., Luang‐In, V., Goh, M. S., Sonne, C., & Ling, N. (2024) · Environmental Research · doi:10.1016/j.envres.2024.118441 · Cited by 13
Nagatomo, R., Kaneko, H., Kamatsuki, S., Ichimura‐Shimizu, M., Ishimaru, N., Tsuneyama, K., & Inoue, K. (2022) · Journal of Chromatography B · doi:10.1016/j.jchromb.2022.123432 · Cited by 14
Effect of In Vivo Administration of Ethylmalonic Acid on Energy Metabolism in Rat Tissues
Ferreira, G. C., André, K. R., Schuck, P. F., et al. (2006) · Metabolic Brain Disease · doi:10.1007/s11011-006-9004-7 · Cited by 12
“Furthermore, it is expected that EMA originated from butyryl-CoA produced in high amounts in the liver of these patients can penetrate into brain and other peripheral tissues since the transporter for short-chain fatty acids is an active carrier across tissues (Oldendorf, 1973), which is in accordance with our present…”
ResultAu-Yeung, S. C. S., Riggs, K. W., Gruber, N., et al. (2007) · Drug Metabolism and Disposition · doi:10.1124/dmd.106.013995 · Cited by 12
“Many transporters are present at the BBB to deliver a range of substances into the CNS (Oldendorf, 1973), including sodium-independent organic cation transporters (Koepsell, 1998).”
Background1-[11C]Pyruvate turnover in brain and muscle of patients with mitochondrial encephalomyopathy
Yokoi, F., Hara, T., Iio, M., et al. (1990) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(90)90168-m · Cited by 12
The origin of free brain malonate
Riley, K. M., Dickson, A. C., & Koeppen, A. H. (1991) · Neurochemical Research · doi:10.1007/bf00965698 · Cited by 12
“Oldenorf (8) reported a similar barrier for other dicarboxylic acids.”
BackgroundMatheson, D. F., Oei, R., & Roots, B. I. (1980) · Neurochemical Research · doi:10.1007/bf00964707 · Cited by 12
Untersuchungen zur Genese und Biochemie der Pansenacidose
Giesecke, D., & Stangassinger, M. (2010) · Zentralblatt für Veterinärmedizin Reihe A · doi:10.1111/j.1439-0442.1979.tb00654.x · Cited by 12
Transport at the Blood–Brain Barrier
Neuhaus, W., & Noe, C. (2009) · Methods and principles in medicinal chemistry · doi:10.1002/9783527627424.ch10 · Cited by 16
Neurochemical Aspects of Blood-Brain-Cerebrospinal Fluid Barriers
Cutler, R. W. P. (1980) · Springer eBooks · doi:10.1007/978-1-4684-1039-6_4 · Cited by 12
Hypophagia induced by endogenous or liposome-encapsulated 3,4-dihydroxybutanoic acid
Terada, K., Sakata, T., Oomura, Y., Fujimoto, K., Arase, K., Osanai, T., & Nagai, Y. (1986) · Physiology & Behavior · doi:10.1016/0031-9384(86)90055-7 · Cited by 12
Characteristics of lactate transfer in isolated cardiac myocytes
Kammermeier, H., WEIN, B. B., & Graf, W. D. (1984) · Steinkopff eBooks · doi:10.1007/978-3-662-11041-6_10 · Cited by 12
Deme, P., Rojas, C. J., Slusher, B. S., Rais, R., Afghah, Z., Geiger, J. D., & Haughey, N. J. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113181 · Cited by 10
“The primary MCT isoforms that are found in the brain include MCT1 that is expressed in endothelial cells of the blood brain barrier with some expression in astrocytes, and MCT2 that is primarily expressed in neurons (Oldendorf, 1973; Simpson et al., 2007).”
BackgroundLalatsa, A., Schätzlein, A. G., & Uchegbu, I. F. (2012) · Royal Society of Chemistry eBooks · doi:10.1039/9781849735292-00329 · Cited by 12
Suppression of an ethanol withdrawal syndrome in rats by butyrate, lactate and β-hydroxybutyrate
Derr, R. F., Draves, K., & Derr, M. I. (1983) · Life Sciences · doi:10.1016/0024-3205(83)90237-0 · Cited by 11
Untersuchungen zur Genese und Biochemie der Pansenacidose
Giesecke, D., & Stangassinger, M. (2010) · Zentralblatt für Veterinärmedizin Reihe A · doi:10.1111/j.1439-0442.1978.tb00932.x · Cited by 11
Memory processes and memory systems: Fractionation of human memory
Hijman, R. (1996) · Neuroscience Research Communications · doi:10.1002/(sici)1520-6769(199611)19:3 · Cited by 2
The role of acetate as a potential mediator of the effects of ethanol in the brain
Brundege, J. M., & Dunwiddie, T. V. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)11320-v · Cited by 11
Ameen, A. O., Nielsen, S. W., Kjær, M. W., Andersen, J. V., Westi, E. W., Freude, K., & Aldana, B. I. (2024) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x241270457 · Cited by 13
“57 When cerebral cortical slices and cultured astrocytes were incubated with [1,2-13 C]acetate and unlabelled 12 C-butyrate, a reduction in 13 C enrichment of a majority of the TCA metabolites occurred.”
Fujita, A., Ihara, K., Kawai, H., Obuchi, S. P., Watanabe, Y., Hirano, H., Fujiwara, Y., Takeda, Y., Tanaka, M., & Kato, K. (2022) · Discover Mental Health · doi:10.1007/s44192-022-00023-0 · Cited by 10
“SCFAs can cross the blood–brain barrier and are found in human CSF [77].”
BackgroundDifferent effects of monocarboxylates on neuronal survival and β‐amyloid toxicity
Wang, X., Takata, T., Sakurai, T., & Yokono, K. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05853.x · Cited by 10
“In addition, as pyruvate can cross the blood–brain barrier (Oldendorf, 1973), it could be of therapeutic value in pathological situations such as ischemiareperfusion or trauma, in which the acute production of free radicals is believed to play a critical role (Desagher et al., 1997).”
BackgroundWajner, A., Bürger, C., Dutra‐Filho, C. S., et al. (2007) · Metabolic Brain Disease · doi:10.1007/s11011-007-9046-5 · Cited by 10
“In this scenario, transport of branched-chain amino acids and keto acids into brain through the blood-brain barrier seems to be effective and quick (Oldendorf, 1973; Steele, 1986).”
BackgroundComputer modeling of blood brain barrier permeability for physiologically active compounds
Raevsky, O. A., Solodova, S. L., Lagunin, A. A., et al. (2013) · Biochemistry (Moscow) Supplement Series B Biomedical Chemistry · doi:10.1134/s199075081302008x · Cited by 10
The ethanol withdrawal syndrome: A consequence of lack of substrate for a cerebral Krebs-cycle
Derr, R. F. (1984) · Journal of Theoretical Biology · doi:10.1016/0022-5193(84)90036-5 · Cited by 10
Ohtsuki, S. (2004) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.124.791 · Cited by 10
Effects of hypoxia on rat brain metabolism: Unilateral in vivo carotid infusion
Рапопорт, С. И., Lust, W. D., & Fredericks, W. R. (1986) · Experimental Neurology · doi:10.1016/0014-4886(86)90072-5 · Cited by 10
Regen, D. M., Callis, J. T., & Sugden, M. C. (1983) · Brain Research · doi:10.1016/0006-8993(83)90291-3 · Cited by 10
Glucose is required to maintain ATP/ADP ratio of isolated bovine cerebral microvessels
Gaposchkin, C. G., Tornheim, K., Sussman, I., et al. (1990) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1990.258.3.e543 · Cited by 10
Al-Akl, N. S., Khalifa, O., Ponirakis, G., Parray, A., Ramadan, M., Khan, S., Chandran, M., Ayadathil, R., Elsotouhy, A., Own, A. M., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25042247 · Cited by 9
“AKG can enter the brain through different mechanisms, including carrier-mediated processes, simple diffusion, and transport across mitochondrial membranes [53,54].”
BackgroundMetabolic Dysfunctions in Epilepsy and Novel Metabolic Treatment Approaches
Tan, K. N., McDonald, T. S., & Borges, K. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-411462-3.00048-5 · Cited by 11
Walker, I., Nicholls, D., Irwin, W. J., et al. (1994) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(94)90131-7 · Cited by 9
Kuge, Y., Kawashima, H., Yamazaki, S., et al. (1996) · Nuclear Medicine and Biology · doi:10.1016/s0969-8051(96)00148-5 · Cited by 9
The Influence of Liver-Bypass on Transport and Compartmentation In Vivo
Cremer, J. E. (1976) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-3264-0_8 · Cited by 9
Duve, K. V., Petakh, P., & Kamyshnyi, O. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1406874 · Cited by 11
“The increased expression of monocarboxylate transporters (MCTs) in endothelial cells could facilitate the passage of SCFAs across the BBB, as evidenced by studies administering labeled SCFAs directly into the carotid artery of rats (Oldendorf, 1973; Vijay and Morris, 2014).”
BackgroundSchurr, A. (2002) · Humana Press eBooks · doi:10.1007/978-1-59259-108-4_2 · Cited by 8
Hara, T., Yokoi, F., & Iio, M. (1986) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/bf00638790 · Cited by 8
“Pyruvate is supplied to brain cells either as the end-product of intracellular glycolysis or by direct penetration from the blood across the blood-brain barrier (Oldendorf 1973), although the contribution of the latter is comparatively small in physiological terms (Pardridge and Oldendorf 1977).”
BackgroundEffect of Probenecid on Cerebral and Cisternal Cerebrospinal Fluid Lactate Content
MacMillan, V. (1987) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1987.17 · Cited by 8
“…could have been ex pected from previous studies that showed an inhibi tory effect of probenecid on endothelial monocar boxylic acid transport (Pardridge et al., 1975; Yu wiler et aI., 1982) and from the suggestion that lactate shares with probenecid and 5-HIAA a common saturable carrier from…”
ResultNagatsugi, F., Sasaki, S., & Maëda, M. (1994) · Nuclear Medicine and Biology · doi:10.1016/0969-8051(94)90160-0 · Cited by 8
Preferential accumulation of 11C in human brain tumors after intravenous injection of 11C-1-pyruvate
Tsukiyama, T., Hara, T., Iio, M., et al. (1986) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/bf00251978 · Cited by 8
Yamazaki, S., Fukui, K., Kawashima, H., Kuge, Y., Miyake, Y., & Kangawa, K. (1996) · Annals of Nuclear Medicine · doi:10.1007/bf03164800 · Cited by 8
Sakiyama, Y., Ishiwata, K., Ishii, K., et al. (1996) · Annals of Nuclear Medicine · doi:10.1007/bf03164748 · Cited by 8
Blood‐brain barrier permeability during shortlasting intravascular hyperosmolality
Paulson, O. B., & Hertz, M. M. (1978) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1978.tb00870.x · Cited by 8
Ethanol and the Blood-Brain Barrier
Chin, J. H. (1979) · Springer eBooks · doi:10.1007/978-1-4684-3450-7_7 · Cited by 8
Transport of Hexoses and Monocarboxylic Acids
BACHELARD, H. S. (1983) · Springer eBooks · doi:10.1007/978-1-4899-4555-6_16 · Cited by 8
The role of nutrition in canine idiopathic epilepsy management: Fact or fiction?
Verdoodt, F., Watanangura, A., Bhatti, S. F. M., Schmidt, T., Suchodolski, J. S., Ham, L. V., Meller, S., Volk, H. A., & Hesta, M. (2022) · The Veterinary Journal · doi:10.1016/j.tvjl.2022.105917 · Cited by 8
Kuge, Y., Kawashima, H., Hashimoto, T., Imanishi, M., Shiomi, M., Minematsu, K., Hasegawa, Y., Yamaguchi, T., Miyake, Y., & Hashimoto, N. (2000) · Annals of Nuclear Medicine · doi:10.1007/bf02990482 · Cited by 7
Kuge, Y., Hikosaka, K., Seki, K., Ohkura, K., Nishijima, K., Tsukamoto, E., & Tamaki, N. (2002) · Nuclear Medicine and Biology · doi:10.1016/s0969-8051(01)00309-2 · Cited by 8
Ishiwata, K., Ishii, K., Ogawa, K., et al. (1996) · Annals of Nuclear Medicine · doi:10.1007/bf03165404 · Cited by 7
(1979) · Food and Cosmetics Toxicology · doi:10.1016/s0015-6264(79)80017-6 · Cited by 7
Aigner, A. M., Wolf, S., & Gassen, H. G. (1997) · Angewandte Chemie · doi:10.1002/ange.19971090105 · Cited by 7
Mabry, S. J., Cao, X., Zhu, Y., Rowe, C., Patel, S., González‐Arancibia, C., Romanazzi, T., Saleeby, D. P., Elam, A., Lee, H.-T., et al. (2025) · Science Signaling · doi:10.1126/scisignal.adx7729 · Cited by 7
The role of gut-derived short-chain fatty acids in Parkinson's disease
Saadh, M. J., Mustafa, A. N., Mustafa, M. A., Renuka Jyothi, S., Dabis, H. K., Prasad, G. V. S., Mohammad, I. J., Adnan, A., & Idan, A. H. (2024) · Neurogenetics · doi:10.1007/s10048-024-00779-3 · Cited by 9
“In preclinical PD models, SCFAs have demonstrated the ability to traverse the BBB, facilitating direct interactions with brain cells [333].”
Choi, J. K., Kwon, O. Y., & Lee, S. H. (2024) · Food Science of Animal Resources · doi:10.5851/kosfa.2024.e5 · Cited by 7
“In addition, studies have shown that SCFAs produced by the gut microbiota move into the bloodstream and finally reach the brain by penetrating the blood-brain barrier (Kekuda et al., 2013; Oldendorf, 1973).”
BackgroundPrevention of Neurologic Disease with Fasting
Macri, E., & Azhar, Y. (2022) · Seminars in Neurology · doi:10.1055/a-1957-8449 · Cited by 6
Coupling of Blood Flow to Neuronal Excitability
GJEDDE, A. H. (2002) · Humana Press eBooks · doi:10.1007/978-1-59259-108-4_9 · Cited by 6
Blood—brain barrier amino-acid transport: clinical implications
Pardridge, W. M. (1982) · Springer eBooks · doi:10.1007/978-94-009-7325-1_6 · Cited by 6
Brain uptake of halogenated products of D-glucal
Homma, Y., Murase, Y., & Ishii, M. (1983) · Journal of Radioanalytical and Nuclear Chemistry · doi:10.1007/bf02517592 · Cited by 6
Structural characteristics of endogenous sugar acids and relations to feeding modulation
Sakata, T., Arase, K., Fujimoto, K., et al. (1988) · Brain Research · doi:10.1016/0006-8993(88)90313-7 · Cited by 6
Malhotra, B. K., Brundage, R. C., Lemaire, M., & Sawchuk, R. J. (1997) · Journal of drug targeting · doi:10.3109/10611869708995843 · Cited by 6
Moțățăianu, A., Ion, V., Dumitreasă, M., Ormenișan, I., Farczádi, L., Andone, S. R., Bălașa, R., & Roman, M. (2025) · Biomolecules · doi:10.3390/biom15101380 · Cited by 7
Prenen, G. H. M., Go, K. G., Paans, A. M. J., et al. (1989) · Acta Neurochirurgica · doi:10.1007/bf01402328 · Cited by 5
Kuge, Y., Hikosaka, K., Seki, K., Ohkura, K., Nishijima, K.-C., Kaji, T., Ueno, S., Tsukamoto, E., & Tamaki, N. (2003) · PubMed · Cited by 5
COMPARISON OF METHODS FOR DETERMINING BLOOD-BRAIN BARRIER PERMEABILITY
Patlak, C. S., & Fenstermacher, J. D. (1975) · Elsevier eBooks · doi:10.1016/b978-0-12-197450-3.50008-4 · Cited by 5
Davson, H., Zloković, B. V., Rakić, L., & Segal, M. B. (1993) · doi:10.1007/978-1-349-11882-3_1 · Cited by 6
Puchowicz, M. A., Xu, K., & LaManna, J. C. (2003) · Humana Press eBooks · doi:10.1385/1-59259-419-0:265 · Cited by 5
Development of the Blood-Brain Barrier
Laterra, J., & Goldstein, G. W. (2004) · Elsevier eBooks · doi:10.1016/b978-0-7216-9654-6.50169-7 · Cited by 5
Non-Anticoagulant Actions of Glycosaminoglycans (GAGs)
Cornelli, U. (1996) · Springer eBooks · doi:10.1007/978-1-4613-0371-8_20 · Cited by 5
Dagbasi, A., Cai, M., Hirdaramani, A., Hanyaloglu, A. C., Morrison, D. J., & Frost, G. S. (2026) · Nature Metabolism · doi:10.1038/s42255-026-01579-9 · Cited by 6
“Acetate and propionate can cross the blood–brain barrier through monocarboxylate transporters, reaching micromolar concentrations in brain tissue 185,186 .”
Interplay of alpha-synuclein pathology and gut microbiome in Parkinson’s disease
Srivastava, A., Kataria, A., Yadav, D. K., Han, I., & Choi, E. H. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-91313-3.00003-9 · Cited by 4
Neurodevelopment and the gut microbiome
Oliphant, K., & Lu, J. N. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-820602-7.00006-4 · Cited by 6
Automated production of [11C]butyrate for keto body PET imaging
Pakula, R. J., Raffel, D. M., Koeppe, R. A., et al. (2023) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2023.108315 · Cited by 4
Entry and Deposit of Aluminum in the Brain
Wang, L. (2023) · Springer eBooks · doi:10.1007/978-981-99-1592-7_3 · Cited by 4
Metabolic Interactions between Neurons and Glial Cells
Poitry‐Yamate, C., & Pournaras, C. J. (2011) · Elsevier eBooks · doi:10.1016/b978-0-323-05714-1.00012-1 · Cited by 4
Transport of α-Ketoisocaproate in Neuroblastoma NB-2a Cells
Bachowska-Mac, M., Nehlig, A., ȩ, M. J. N., et al. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7001 · Cited by 4
Gokulan, K., Karn, K., Sarkar, S., Raymick, J. B., & Khare, S. (2025) · Journal of Alzheimer s Disease Reports · doi:10.1177/25424823251358414 · Cited by 3
“38 Interestingly, in the HFD-fed WT males and TG females, the FR of plg was signi fi cantly higher along with several other AD-related genes; implicating a potential role for plasminogen in the gut-brain axis.”
Zeamer, A. L., Lai, Y., Loew, E. B., Sanborn, V. E., Tracy, M., Jo, C., Ferdinand, D., Ward, D. V., Bhattarai, S. K., Drake, J., et al. (2026) · Gut Microbes · doi:10.1080/19490976.2026.2676162 · Cited by 6
Neurosteroids, Microbiota, and Neuroinflammation: Mechanistic Insights and Therapeutic Perspectives
Tahri, A., Niccolai, E., & Amedei, A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26147023 · Cited by 3
“In addition to their metabolic functions, SCFAs are involved in the regulation of inflammatory pathways and neuroinflammation [142–144].”
Processus de transport à travers la barrière hémato-encéphalique
Lefauconnier, J.-M. (1989) · annales de biologie animale biochimie biophysique · doi:10.1051/rnd:19890608 · Cited by 3
Short-Chain Fatty Acids-A Healthy Bus between Gut Microbiota and Organs beyond the Gut
Cao, R., Zeng, Y., Li, S., Xue, P., & Li, M. (2022) · Advances in Bioscience and Biotechnology · doi:10.4236/abb.2022.139024 · Cited by 3
Shaidullov, I. F., Ermakova, E. V., Sorokina, D. M., Yakovleva, O. V., & Ситдикова, Г. Ф. (2023) · BIOPHYSICS · doi:10.1134/s0006350923040188 · Cited by 3
Sakata, T. (1990) · Brain Research Bulletin · doi:10.1016/0361-9230(90)90196-7 · Cited by 3
Huber, A., Bürkle, A., & Münch, G. W. (2007) · Springer eBooks · doi:10.1007/978-0-387-30377-2_6 · Cited by 3
Miller, M. H., & Mayers, M. (2014) · ASM Press eBooks · doi:10.1128/9781555817817.ch18 · Cited by 3
Morton, I. K., Phillips, S. J., Saverymuttu, S. H., et al. (1977) · PubMed · Cited by 3
Nanomedicines for Delivery Across the Blood–Brain Barrier
Lalatsa, A., Das, D., & Osouli-Bostanabad, K. (2024) · Springer eBooks · doi:10.1007/978-3-031-59478-6_11 · Cited by 2
An, K., Qu, Y., Li, J., Wang, D., Mao, Z., & Xue, Z. (2025) · Nutritional Neuroscience · doi:10.1080/1028415x.2025.2558119 · Cited by 2
“But according to Oldendorf et al. [54], SCFAs could cross the blood–brain barrier (BBB) and enter the cephalic regions.”
1‐Kestose Prevents Psychiatric‐Like Behavior by Enhancing Short‐Chain Fatty Acid Production
Tanabe, M., Kunisawa, K., Fujii, T., Tochio, T., Hirooka, Y., Ojika, H., Naruoka, Y., Ito, H., Saito, K., Nabeshima, T., et al. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70273 · Cited by 2
“SCFA can cross the blood–brain barrier and have been reported to suppress microglial activation, a key contributor to neuroin-flammation (Oldendorf 1973; Erny et al. 2015).”
Metadata
- Authors
- Oldendorf, W.
- Corresponding author
- Oldendorf, WH
- Venue
- American Journal of Physiology-Legacy Content
- Publisher
- American Physiological Society
- Published
- 1973-06-01
- Volume
- 224
- Issue
- 6
- Pages
- 1450-1453
- ISSN
- 0002-9513 (ISSN-L)
- OpenAlex
- W2294335852
- Cited by
- 463
- References
- 0
- Citations by year
- 2026: 16 · 2025: 17 · 2024: 21 · 2023: 20 · 2022: 32 · 2021: 13 · 2020: 7 · 2019: 5 · 2018: 9 · 2017: 2 · 2016: 9 · 2015: 4 · 2014: 4 · 2013: 9 · 2012: 6
- FWCI
- 4.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Legacy Content (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Keywords
- blood-brain barrier, carrier-mediated transport, organic acids, brain uptake, monocarboxylate transporters
- MeSH terms
- Acetates, Amino Acids, Animals, Biological Transport, Blood-Brain Barrier, Brain, Butyrates, Carbon Isotopes, Carboxylic Acids, Dicarboxylic Acids, Female, Glucose, Lactates, Male, Propionates, Pyruvates, Tricarboxylic Acids, Tritium, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review