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Carrier-mediated blood-brain barrier transport of short-chain monocarboxylic organic acids
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“The abundant expression of MCTs in endothelial cells (75, 92) might facilitate crossing of the BBB by SCFAs since brain uptake of SCFAs has previously been demonstrated in rats following injection of 14C-SCFAs into the carotid artery (93).”
From The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication (2020) · cites this paper as [93]
In the citing paper
“A small fraction reaches the systemic circulation and can cross the tightly regulated BBB using their own transporters located on brain vascular epithelial cells (100, 101).”
From The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology (2020) · cites this paper as [100]
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Items 401–461 of 461
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The Role of Gut Microbiota-derived Short Chain Fatty Acids in Amyotrophic Lateral Sclerosis
Saadh, M. J., Dhiaa, S. M., Bansal, P., Dabis, H. K., Katyal, A., Saraswat, V., Ibrahim, A. A., Kadem, R. U., & Ubaid, M. (2025) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-024-00292-9 · Cited by 2
“Also, it was observed that all of mentioned SCFAs observed feedback inhibition on their own brain take-up [52].”
Regulación de la utilización del aspartato por los astrocitos durante la prelactancia
Tovar-Franco, J. A., Ortiz, M. J. S., Morales, L., et al. (2009) · Universitas Scientiarum · doi:10.11144/javeriana.sc14-2-3.rdlu · Cited by 2
“El transporte de todos los sustratos a las células nerviosas exige la existencia de sistemas de transporte específicos que se desarrollen con independencia a la formación de la barrera hematoencefálica (BHE).”
BackgroundRetinal and Choroidal Circulations
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Coupling and Compartmentation of Cerebral Blood Flow and Metabolism
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EFFECTS OF OXYGEN INDUCED CONVULSIONS ON THE UPTAKE OF ACETATE INTO RAT BRAIN LIPIDS1,2
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Penetration of glyoxylate across die blood–brain barrier
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Regional blood-brain barrier transport of ketone bodies in portacaval-shunted rats
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Regional Blood to Brain Transport of Lactate
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Kaewsaen, R., Chanput, W. P., Rojanathammanee, L., Golovko, S. A., Seeger, D. R., Golovko, M. Y., Nookala, S., & Combs, C. K. (2025) · Nutrients · doi:10.3390/nu17101677 · Cited by 2
“Further inquiries can be directed to the corresponding author.”
Cho, S., Lee, S., Lee, H. J., Yum, J., Ha, W., Kim, K. M., & Chu, M. K. (2026) · The Journal of Headache and Pain · doi:10.1186/s10194-026-02268-4 · Cited by 2
“Importantly, SCFAs are capable of crossing the blood–brain barrier and modulating CNS function by influencing microglial activation, neurotransmitter bio-synthesis, and the expression of neurotrophic factors [14–16].”
Gut Microbiome Strategies for Enhancing ICI Delivery Across the BBB in Glioblastoma
Barati, S., Ghoflchi, S., Nakhaei, A., Yazdi, M., Hosseinzadeh, P., Hosseini, H., & Jalili‐Nik, M. (2026) · BioFactors · doi:10.1002/biof.70077 · Cited by 1
“For example, acetate contributes to the production of acetyl-CoA for protein acetylation, thereby activating mTORC2 and promoting the proliferation and survival of GB [241, 242].”
Wang, Y., Xiao, X., Zheng, B., Bai, D., Zhang, Y., Zhen, W., Zhang, B., & Ma, Y. (2026) · Animals · doi:10.3390/ani16060954 · Cited by 3
“These characteristics allow them to passively diffuse across the lipid bilayer of BBB endothelial cells [72].”
Primary cilia in the hypothalamic AgRP neurons mediate metabolic effects of butyrate
Rijal, S., Yang, D. J., Doan, K. V., Lyoo, S. H., Lee, A., Choi, Y.-H., Shin, D. M., & Kim, K. W. (2026) · Nature Communications · doi:10.1038/s41467-026-71745-w · Cited by 2
“Given that butyrate is the SCFA with the ability to cross the blood – brain barrier 12 , we hypothesized that its accumulation in the central nervous system following chronic peripheral administration at therapeutic doses may be suf fi - cient to inhibit HDACs and promote hypothalamic ciliogenesis.”
Abdel‐Moemin, A. R., El-Megeid, A. A. A., Omar, E., El-Moneim, Y. F. A., Talaat, D. M., & El-Marasy, S. S. (2011) · University of Maribor digital library (University of Maribor) · Cited by 1
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Ngo, S. T., Steyn, F. J., McCombe, P., & Borges, K. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-411462-3.00036-9 · Cited by 1
Triheptanoin in Epilepsy and Beyond
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Dietary Acetate Supplementation Attenuates Neuroinflammation
Soliman, M. L., & Rosenberger, T. A. (2013) · Advances in Neuroimmune Biology · doi:10.3233/nib-130060 · Cited by 1
“Peripherally-derived acetate crosses the blood brain barrier by simple diffusion [47].”
BackgroundSchurr, A., Payne, R. S., Miller, J. J., & Rigor, B. M. (1998) · Advances in behavioral biology · doi:10.1007/978-1-4615-5337-3_24 · Cited by 1
Structural composition and metabolism of [2-14C]propionate in the rat aorta
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Metabolite Transport in the Nervous System
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Metabolite transport through the blood-brain barrier.
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“Rodent studies have demonstrated that acetate can cross the blood-brain barrier (BBB), as evidenced by the detection of 14 C-labeled SCFAs in brain tissue following carotid artery injection 60 .”
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“…neuronal energy substrate glucose is transported into neurons via GLUT3 [73], exogenously supplied or endogenously generated pyruvate gains access to the brain and neurons through neurovascular MCT interconnections comprising endothelial and glial MCT1, glial MCT4, and neuronal MCT2 [74,75].”
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“…in gut-brain axis may include vagal nerve activity, cytokine signalling, immune cell trafficking, endocrine signalling and microbiota-derived metabolites capable of traversing or signalling through the blood brain barrier (BBB)(Braniste et al., 2014; Morais et al., 2021; Oldendorf, 1973).”
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“Among microbial metabolites, SCFAs, including acetate, propionate, and butyrate, are considered the primary functional outputs of microbial fermentation with potent biological activity [34].”
Metabolic Outputs of the Gut Microbiome: Implications for Epilepsy
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“A small proportion enters the systemic circulation after absorption across the colonic epithelium and can cross the BBB via transporters on brain endothelial cells [145].”
Metadata
- Authors
- Oldendorf, W.
- Corresponding author
- Oldendorf, WH
- Venue
- American Journal of Physiology-Legacy Content
- Publisher
- American Physiological Society
- Published
- 1973-06-01
- Volume
- 224
- Issue
- 6
- Pages
- 1450-1453
- ISSN
- 0002-9513 (ISSN-L)
- OpenAlex
- W2294335852
- Cited by
- 463
- References
- 0
- Citations by year
- 2026: 16 · 2025: 17 · 2024: 21 · 2023: 20 · 2022: 32 · 2021: 13 · 2020: 7 · 2019: 5 · 2018: 9 · 2017: 2 · 2016: 9 · 2015: 4 · 2014: 4 · 2013: 9 · 2012: 6
- FWCI
- 4.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Legacy Content (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Keywords
- blood-brain barrier, carrier-mediated transport, organic acids, brain uptake, monocarboxylate transporters
- MeSH terms
- Acetates, Amino Acids, Animals, Biological Transport, Blood-Brain Barrier, Brain, Butyrates, Carbon Isotopes, Carboxylic Acids, Dicarboxylic Acids, Female, Glucose, Lactates, Male, Propionates, Pyruvates, Tricarboxylic Acids, Tritium, Rats
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