Permeability limitation in estimation of local brain blood flow with [14C]antipyrine
Abstract
Influence of capillary permeability on local cerebral blood flow (LCBF) estimated by the autoradiograhpic diffusible-indicator method was analyzed by computer simulation. Its influence increases with increasing flow. With normal perfusion rates in gray matter, capillary permeability coefficient x surface area (PS value) must exceed 0.12 cm3-s(-1)-g(-1) for estimated LCBF to attain 95% of true values in all structures. In white matter, with its lower perfusion rates, the PS value must exceed 0.035 cm3-s(-1)-g(-1) for equivalent accuracy. [14C]antipyrine, widely used in the LCBF technique, has a PS value below these values and leads to undersestimation of LCBF. Experimental studies in cats in which LCBF was measured with either [14C]antipyrine or the freely diffusible, radioactive gas, [131I]trifluoroiodomethane, demonstrated consistently lower estimates of LCBF with [14C]antipyrine than with the gas; the deviations in the various cerebral structures approximated those predicted by the theoretical analyses. These results suggest that the uptake of [14C]antipyrine by cerebral tissues is diffusion limited as well as flow limited, and it therefore is not an ideal tracer for the autoradiographic LCBF technique.
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Such brain-wide activations during REMS have not been detected or reported over the past 50 years, other than using autoradiography.
“To the best of our knowledge, such activations have surprisingly not yet been detected nor reported over the past 50 years, other than using autoradiography21”
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- Authors
- Eckman, W., Phair, R., Fenstermacher, J., Patlak, C., Kennedy, C., & Sokoloff, L.
- Venue
- American Journal of Physiology-Legacy Content
- Publisher
- American Physiological Society
- Published
- 1975-07-01
- Volume
- 229
- Issue
- 1
- Pages
- 215-221
- ISSN
- 0002-9513 (ISSN-L)
- OpenAlex
- W2417320512
- Cited by
- 85
- References
- 0
- Citations by year
- 2018: 1 · 2015: 1
- FWCI
- 5.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Legacy Content (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- regional cerebral blood flow, capillary permeability, white matter perfusion, gray matter perfusion
- MeSH terms
- Animals, Antipyrine, Blood Flow Velocity, Blood Volume, Blood-Brain Barrier, Capillary Permeability, Cats, Cerebrovascular Circulation, Computers, Indicator Dilution Techniques, Methods, Models, Biological
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