The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
First contact: the role of respiratory cilia in host-pathogen interactions in the airways
Open accessAbstract
Respiratory cilia are the driving force of the mucociliary escalator, working in conjunction with secreted airway mucus to clear inhaled debris and pathogens from the conducting airways. Respiratory cilia are also one of the first contact points between host and inhaled pathogens. Impaired ciliary function is a common pathological feature in patients with chronic airway diseases, increasing susceptibility to respiratory infections. Common respiratory pathogens, including viruses, bacteria, and fungi, have been shown to target cilia and/or ciliated airway epithelial cells, resulting in a disruption of mucociliary clearance that may facilitate host infection. Despite being an integral component of airway innate immunity, the role of respiratory cilia and their clinical significance during airway infections are still poorly understood. This review examines the expression, structure, and function of respiratory cilia during pathogenic infection of the airways. This review also discusses specific known points of interaction of bacteria, fungi, and viruses with respiratory cilia function. The emerging biological functions of motile cilia relating to intracellular signaling and their potential immunoregulatory roles during infection will also be discussed.
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Cites
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Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model
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Cellular signalling by primary cilia in development, organ function and disease
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“They sense and transduce environmental cues to maintain cellular homeostasis and are involved in various cellular functions ranging from proliferation, differentiation, regulation of inflammation, and embryonic development (5, 165).”
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Airway Epithelial Differentiation and Mucociliary Clearance
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Bacterial and viral infections associated with influenza
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Influenza-associated Aspergillosis in Critically Ill Patients
van de Veerdonk, F. L., Kolwijck, E., Lestrade, P. P. A., Hodiamont, C. J., Rijnders, B. J. A., van Paassen, J., Haas, P.-J., Oliveira dos Santos, C., Kampinga, G. A., Bergmans, D. C. J. J., et al. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201612-2540le · Cited by 230
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Cited by
Kumar, P., Singh, A. B., Arora, T., Singh, S., & Singh, R. (2023) · Science of The Total Environment · doi:10.1016/j.scitotenv.2023.162163 · Cited by 380
Metadata
- Authors
- Kuek, L. E., & Lee, R. J.
- Venue
- American Journal of Physiology-Lung Cellular and Molecular Physiology
- Publisher
- American Physiological Society
- Published
- 2020-10-01
- Volume
- 319
- Issue
- 4
- Pages
- L603-L619
- ISSN
- 1040-0605 (ISSN-L)
- 1522-1504
- OpenAlex
- W3048437006
- Cited by
- 185
- References
- 14
- FWCI
- 11.57
- Type
- journal article
- Language
- en
- Open access
- green
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- Kuek, L. E., & Lee, R. J. (2020). First contact: the role of respiratory cilia in host-pathogen interactions in the airways. American Journal of Physiology-Lung Cellular and Molecular Physiology. https://doi.org/10.1152/ajplung.00283.2020
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
