Airway Epithelial Differentiation and Mucociliary Clearance

The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary.Preprint

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Notch Signaling in Development, Tissue Homeostasis, and Disease

Siebel, C., & Lendahl, U. (2017) · Physiological Reviews · doi:10.1152/physrev.00005.2017 · Cited by 968 · see citing works

Cilia and Mucociliary ClearancePreprint

Bustamante-Marin, X. M., & Ostrowski, L. E. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028241 · Cited by 836 · see citing works

Respiratory epithelial cells orchestrate pulmonary innate immunity

Whitsett, J. A., & Alenghat, T. (2014) · Nature Immunology · doi:10.1038/ni.3045 · Cited by 804 · see citing works

Muc5b is required for airway defence

Roy, M. G., Livraghi-Butrico, A., Fletcher, A. A., McElwee, M. M., Evans, S. E., Boerner, R. M., Alexander, S. N., Bellinghausen, L. K., Song, A. S., Petrova, Y. M., et al. (2014) · Nature · doi:10.1038/nature12807 · Cited by 764 · see citing works

European Respiratory Society guidelines for the diagnosis of primary ciliary dyskinesia

Lucas, J. S., Barbato, A., Collins, S. A., Goutaki, M., Behan, L., Caudri, D., Dell, S., Eber, E., Escudier, E., Hirst, R. A., et al. (2016) · European Respiratory Journal · doi:10.1183/13993003.01090-2016 · Cited by 706 · see citing works

Single-cell RNA sequencing identifies diverse roles of epithelial cells in idiopathic pulmonary fibrosis

Xu, Y. J., Mizuno, T., Sridharan, A., Du, Y., Guo, M., Tang, J., Wikenheiser‐Brokamp, K. A., Perl, A. T., Funari, V. A., Gokey, J. J., et al. (2016) · JCI Insight · doi:10.1172/jci.insight.90558 · Cited by 571 · see citing works

Early restriction of peripheral and proximal cell lineages during formation of the lung

Perl, A. T., Wert, S. E., Nagy, A., Lobe, C. G., & Whitsett, J. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.152238499 · Cited by 525 · see citing works

Diagnosis, monitoring, and treatment of primary ciliary dyskinesia: PCD foundation consensus recommendations based on state of the art review

Shapiro, A. J., Zariwala, M. A., Ferkol, T. W., Davis, S. D., Sagel, S. D., Dell, S., Rosenfeld, M., Olivier, K. N., Milla, C. E., Daniel, S. J., et al. (2015) · Pediatric Pulmonology · doi:10.1002/ppul.23304 · Cited by 458 · see citing works

Mucins, Mucus, and Goblet Cells

Ma, J., Rubin, B. K., & Voynow, J. A. (2017) · CHEST Journal · doi:10.1016/j.chest.2017.11.008 · Cited by 411 · see citing works

SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production

Chen, G., Korfhagen, T. R., Xu, Y. J., Kitzmiller, J. A., Wert, S. E., Maeda, Y., Gregorieff, A., Clevers, H. C., & Whitsett, J. A. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39731 · Cited by 403 · see citing works

Airway Mucus and Asthma: The Role of MUC5AC and MUC5B

Bonser, L. R., & Erle, D. J. (2017) · Journal of Clinical Medicine · doi:10.3390/jcm6120112 · Cited by 357 · see citing works

Multiple roles for Sox2 in the developing and adult mouse trachea

Que, J., Luo, X., Schwartz, R. J., & Hogan, B. L. M. (2009) · Development · doi:10.1242/dev.034629 · Cited by 322 · see citing works

The polymeric mucin Muc5ac is required for allergic airway hyperreactivity

Evans, C. M., Raclawska, D. S., Ttofali, F., Liptzin, D. R., Fletcher, A. A., Harper, D. N., McGing, M., McElwee, M. M., Williams, O. W., Sánchez, E., et al. (2015) · Nature Communications · doi:10.1038/ncomms7281 · Cited by 294 · see citing works

Human embryonic lung epithelial tips are multipotent progenitors that can be expanded in vitro as long-term self-renewing organoids

Nikolić, M., Caritg, O., Jeng, Q., Johnson, J.-A., Sun, D., Howell, K. J., Brady, J., Laresgoiti, U., Allen, G. E., Butler, R., et al. (2017) · eLife · doi:10.7554/elife.26575 · Cited by 270 · see citing works

Multicilin promotes centriole assembly and ciliogenesis during multiciliate cell differentiation

Stubbs, J. L., Vladar, E. K., Axelrod, J. D., & Kintner, C. R. (2012) · Nature Cell Biology · doi:10.1038/ncb2406 · Cited by 241 · see citing works

Canonical Notch signaling in the developing lung is required for determination of arterial smooth muscle cells and selection of Clara versus ciliated cell fate

Morimoto, M., Liu, Z., Cheng, H., Winters, N., Bader, D. M., & Kopan, R. (2010) · Journal of Cell Science · doi:10.1242/jcs.058669 · Cited by 235 · see citing works

Sensory reception is an attribute of both primary cilia and motile cilia

Bloodgood, R. A. (2010) · Journal of Cell Science · doi:10.1242/jcs.066308 · Cited by 218 · see citing works

Tonicity-dependent induction of Sgk1 expression has a potential role in dehydration-induced natriuresis in rodents

Chen, S., Grigsby, C. L., Law, C. S., Ni, X.-P., Nekrep, N., Olsen, K., Humphreys, M. H., & Gardner, D. G. (2009) · Journal of Clinical Investigation · doi:10.1172/jci35314 · Cited by 214 · see citing works

Different assemblies of Notch receptors coordinate the distribution of the major bronchial Clara, ciliated and neuroendocrine cells

Morimoto, M., Nishinakamura, R., Saga, Y., & Kopan, R. (2012) · Development · doi:10.1242/dev.083840 · Cited by 209 · see citing works

Airway Gland Structure and Function

Widdicombe, J. H., & Wine, J. J. (2015) · Physiological Reviews · doi:10.1152/physrev.00039.2014 · Cited by 204 · see citing works

Airway mucus, inflammation and remodeling: emerging links in the pathogenesis of chronic lung diseases

Zhou-Suckow, Z., Duerr, J., Hagner, M., Agrawal, R., & Mall, M. A. (2017) · Cell and Tissue Research · doi:10.1007/s00441-016-2562-z · Cited by 186 · see citing works

Ectopic respiratory epithelial cell differentiation in bronchiolised distal airspaces in idiopathic pulmonary fibrosis

Plantier, L., Crestani, B., Wert, S. E., et al. (2011) · Thorax · doi:10.1136/thx.2010.151555 · Cited by 177 · see citing works

Airway epithelial SPDEF integrates goblet cell differentiation and pulmonary Th2 inflammation

Rajavelu, P., Chen, G., Xu, Y. J., Kitzmiller, J. A., Korfhagen, T. R., & Whitsett, J. A. (2015) · Journal of Clinical Investigation · doi:10.1172/jci79422 · Cited by 159 · see citing works

Human lung branching morphogenesis is orchestrated by the spatiotemporal distribution of ACTA2, SOX2, and SOX9

Danopoulos, S., Alonso, I., Thornton, M. E., Grubbs, B. H., Bellusci, S., Warburton, D., & Alam, D. A. (2017) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00379.2017 · Cited by 155 · see citing works

Active epithelial Hippo signaling in idiopathic pulmonary fibrosis

Gokey, J. J., Sridharan, A., Xu, Y. J., Green, J., Carraro, G., Stripp, B. R., Perl, A. T., & Whitsett, J. A. (2018) · JCI Insight · doi:10.1172/jci.insight.98738 · Cited by 146 · see citing works

Foxa3 Induces Goblet Cell Metaplasia and Inhibits Innate Antiviral Immunity

Chen, G., Korfhagen, T. R., Karp, C. L., Impey, S., Xu, Y. J., Randell, S. H., Kitzmiller, J. A., Maeda, Y., Haitchi, H. M., Sridharan, A., et al. (2014) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201306-1181oc · Cited by 139 · see citing works

Lung Gene Expression Analysis (LGEA): an integrative web portal for comprehensive gene expression data analysis in lung development

Du, Y., Kitzmiller, J. A., Sridharan, A., et al. (2017) · Thorax · doi:10.1136/thoraxjnl-2016-209598 · Cited by 138 · see citing works

The normal trachea is cleaned by MUC5B mucin bundles from the submucosal glands coated with the MUC5AC mucin

Ermund, A., Meiss, L. N., Rodríguez-Piñeiro, A. M., et al. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.08.113 · Cited by 127 · see citing works

RFX3 Modulation of FOXJ1 regulation of cilia genes in the human airway epithelium

Didon, L., Zwick, R. K., Chao, I. W., Walters, M. S., Wang, R., Hackett, N. R., & Crystal, R. G. (2013) · Respiratory Research · doi:10.1186/1465-9921-14-70 · Cited by 101 · see citing works

Gmnc Is a Master Regulator of the Multiciliated Cell Differentiation Program

Zhou, F., Narasimhan, V., Shboul, M., Chong, Y. L., Reversade, B., & Roy, S. (2015) · Current Biology · doi:10.1016/j.cub.2015.10.062 · Cited by 99 · see citing works

GemC1 controls multiciliogenesis in the airway epithelium

Arbi, M., Pefani, D., Kyrousi, C., Lalioti, M., Kalogeropoulou, A., Papanastasiou, A. D., Taraviras, S. L., & Lygerou, Z. (2016) · EMBO Reports · doi:10.15252/embr.201540882 · Cited by 95 · see citing works

MUC1 Mucin

Kim, K. C., & Lillehoj, E. P. (2008) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2008-0169tr · Cited by 79 · see citing works

Reflex regulation of airway sympathetic nerves in guinea‐pigs

Oh, E. J., Mazzone, S. B., Canning, B. J., et al. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2005.104661 · Cited by 64 · see citing works

Gmnc Is a Master Regulator of the Multiciliated Cell Differentiation Program

Zhou, F., Narasimhan, V., Shboul, M., Chong, Y. L., Reversade, B., & Roy, S. (2017) · Current Biology · doi:10.1016/j.cub.2016.12.051 · Cited by 59 · see citing works

Salivary Mucin 19 Glycoproteins

Culp, D. J., Robinson, B., Cash, M. N., Bhattacharyya, I., Stewart, C., & Cuadra-Saenz, G. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.597906 · Cited by 58 · see citing works

Mucus Hyperconcentration as a Unifying Aspect of the Chronic Bronchitic Phenotype

Boucher, R. C., Anderson, W. H., & Button, B. M. (2020) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/0rky-5784 · Cited by 57 · see citing works

Mucus Hyperconcentration as a Unifying Aspect of the Chronic Bronchitic Phenotype.

Button, B. M., Anderson, W. H., & Boucher, R. C. (2016) · PubMed · doi:10.1513/annalsats.201507-455kv · Cited by 53 · see citing works

SAM-pointed domain ETS factor mediates epithelial cell–intrinsic innate immune signaling during airway mucous metaplasia

Korfhagen, T. R., Kitzmiller, J. A., Chen, G., Sridharan, A., Haitchi, H. M., Hegde, R. S., Divanovic, S., Karp, C. L., & Whitsett, J. A. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1208092109 · Cited by 50 · see citing works

Foxn4 promotes gene expression required for the formation of multiple motile cilia

Campbell, E. P., Quigley, I. K., & Kintner, C. R. (2016) · Development · doi:10.1242/dev.143859 · Cited by 45 · see citing works

Distribution of mucus producing elements in the respiratory tract. Differences between upper and lower airway.

Tos, M. (1983) · PubMed · Cited by 40 · see citing works

Under Pressure: Reduced Cerebral Perfusion as a Risk Factor for Postoperative Delirium in Lung Transplant Recipients

Anderson, B. J., & Diamond, J. M. (2016) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201512-796ed · Cited by 20 · see citing works

Regulation of Human MUC7 Mucin Gene Expression by Cigarette Smoke Extract or Cigarette Smoke and Pseudomonas aeruginosa Lipopolysaccharide in Human Airway Epithelial Cells and in MUC7 Transgenic Mice

Fan, H., & Bobek, L. A. (2010) · The Open Respiratory Medicine Journal · doi:10.2174/1874306401004010063 · Cited by 12 · see citing works

Primary ciliary dyskinesia: keep it on your radar

Rosenfeld, M., Ostrowski, L. E., & Zariwala, M. A. (2017) · Thorax · doi:10.1136/thoraxjnl-2017-210776 · Cited by 7 · see citing works

Aging and Lung Disease

Cho, S. J., & Stout-Delgado, H. W. (2020) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021119-034610 · Cited by 458 · see citing works

Characterization and structural basis of a lethal mouse-adapted SARS-CoV-2

Sun, S., Gu, H., Cao, L., Chen, Q., Ye, Q., Yang, G., Li, R.-T., Fan, H., Deng, Y.-Q., Song, X., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25903-x · Cited by 104 · see citing works

Recent Developments in mRNA-Based Protein Supplementation Therapy to Target Lung Diseases

Sahu, I., Haque, A. K. M. A., Weidensee, B., Weinmann, P., & Kormann, M. S. D. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2019.02.019 · Cited by 104 · see citing works

Innate Immune Responses to Highly Pathogenic Coronaviruses and Other Significant Respiratory Viral Infections

Ahmed-Hassan, H., Sisson, B., Shukla, R. K., Wijewantha, Y., Funderburg, N. T., Li, Z., Hayes, D., Demberg, T., & Liyanage, N. P. M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01979 · Cited by 47 · see citing works

Pulmonary Radioaerosol Mucociliary Clearance Parameters as Potential Outcomes in Primary Ciliary Dyskinesia TrialsPreprint

Marthin, J. K., Holgersen, M. G., Nielsen, K. G., et al. (2023) · medRxiv · doi:10.1101/2023.06.05.23290928

Airway Clearance Techniques for Primary Ciliary Dyskinesia; is the Cystic Fibrosis literature portable?

Schofield, L., Duff, A. J. A., & Brennan, C. A. (2017) · Paediatric Respiratory Reviews · doi:10.1016/j.prrv.2017.03.011 · Cited by 43 · see citing works

Congenital problems of mucociliary clearance: primary ciliary dyskinesia

Rimmer, J. (2012) · Rhinology Journal · doi:10.4193/rhino12.126 · Cited by 4 · see citing works

Mucociliary clearance scan to evaluate primary ciliary dyskinesia in children with bronchiectasis

Shammas, A., Charron, M., & Dell, S. (2011) · Journal of Nuclear Medicine

Congenital problems of mucociliary clearance: primary ciliary dyskinesia

Rimmer, J. (2012) · Rhinology Journal · doi:10.4193/rhino.12.126 · Cited by 2 · see citing works