The DOI matches its Crossref record; 132 of the 132 references it cites were found in a registry or an index.
Keratinocyte and hepatocyte growth factors in the lung: roles in lung development, inflammation, and repair
Abstract
A growing body of evidence indicates that the epithelial-specific growth factors keratinocyte growth factor (KGF), fibroblast growth factor (FGF)-10, and hepatocyte growth factor (HGF) play important roles in lung development, lung inflammation, and repair. The therapeutic potential of these growth factors in lung disease has yet to be fully explored. KGF has been best studied and has impressive protective effects against a wide variety of injurious stimuli when given as a pretreatment in animal models. Whether this protective effect could translate to a treatment effect in humans with acute lung injury needs to be investigated. FGF-10 and HGF may also have therapeutic potential, but more extensive studies in animal models are needed. Because HGF lacks true epithelial specificity, it may have less potential than KGF and FGF-10 as a targeted therapy to facilitate lung epithelial repair. Regardless of their therapeutic potential, studies of the unique roles played by these growth factors in the pathogenesis and the resolution of acute lung injury and other lung diseases will continue to enhance our understanding of the complex pathophysiology of inflammation and repair in the lung.
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Cites
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Cited by
Biology of alveolar type II cells
MASON, R. J. (2006) · Respirology · doi:10.1111/j.1440-1843.2006.00800.x · Cited by 353
Clearance of apoptotic and necrotic cells and its immunological consequences
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Lu, Z., Chang, W., Meng, S., Xu, X., Xie, J., Guo, F., Yang, Y., Qiu, H., & Liu, L. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1488-2 · Cited by 146
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Metadata
- Authors
- Ware, L. B., & Matthay, M. A.
- Venue
- American Journal of Physiology-Lung Cellular and Molecular Physiology
- Publisher
- American Physiological Society
- Published
- 2002-05-01
- Volume
- 282
- Issue
- 5
- Pages
- L924-L940
- ISSN
- 1040-0605 (ISSN-L)
- 1522-1504
- OpenAlex
- W1994008133
- Cited by
- 306
- References
- 132
- FWCI
- 5.29
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ware, L. B., & Matthay, M. A. (2002). Keratinocyte and hepatocyte growth factors in the lung: roles in lung development, inflammation, and repair. American Journal of Physiology-Lung Cellular and Molecular Physiology. https://doi.org/10.1152/ajplung.00439.2001
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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