Apical location of ferroportin 1 in airway epithelia and its role in iron detoxification in the lung
Abstract
Ferroportin 1 (FPN1; aka MTP1, IREG1, and SLC40A1), which was originally identified as a basolateral iron transporter crucial for nutritional iron absorption in the intestine, is expressed in airway epithelia and upregulated when these cells are exposed to iron. Using immunofluorescence labeling and confocal microscopic imaging techniques, we demonstrate that in human and rodent lungs, FPN1 localizes subcellularly to the apical but not basolateral membrane of the airway epithelial cells. The role of airway epithelial cells in iron mobilization in the lung was studied in an in vitro model of the polarized airway epithelium. Normal human bronchial epithelial cells, grown on membrane supports until differentiated, were exposed to iron, and the efficiency and direction of iron transportation were studied. We found that these cells can efficiently take up iron across the apical but not basolateral surface in a concentration-dependent manner. Most of the iron taken up by the cells is then released into the medium within 8 h in the form of less reactive protein-bound complexes including ferritin and transferrin. Interestingly, iron release also occurred across the apical but not basolateral membrane. Our findings indicate that FPN1, depending on its subcellular location, could have distinct functions in iron homeostasis in different cells and tissues. Although it is responsible for exporting nutrient iron from enterocytes to the circulation in the intestine, it could play a role in iron detoxification in airway epithelial cells in the lung.
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Airway epithelial cells may be efficient in reducing non-transferrin-bound iron, converting it to less toxic protein-bound iron.
“The airway epithelial cells, acting as the first line defence against environmental insults, including asbestos, may be efficient in reducing non-transferrin-bound iron, converting it to less toxic protein-bound iron2122.”
From The interaction of asbestos and iron in lung tissue revealed by synchrotron-based scanning X-ray microscopy (2013) · cites this paper as [22]
Cites
Cloning and characterization of a mammalian proton-coupled metal-ion transporter
Gunshin, H., Mackenzie, B., Berger, U. V., Gunshin, Y., Romero, M. F., Boron, W. F., Nussberger, S., Gollan, J. L., & Hediger, M. A. (1997) · Nature · doi:10.1038/41343 · Cited by 3,166 · see citing works
Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter
Donovan, A., Brownlie, A., Zhou, Y., Shepard, J., Pratt, S. J., Moynihan, J., Paw, B. H., Drejer, A., Barut, B., Zapata, A., et al. (2000) · Nature · doi:10.1038/35001596 · Cited by 1,667 · see citing works
McKie, A. T., Marciani, P., Rolfs, A., Brennan, K., Wehr, K., Barrow, D., Miret, S., Bomford, A., Peters, T. J., Farzaneh, F., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80425-6 · Cited by 1,422 · see citing works
A Novel Mammalian Iron-regulated Protein Involved in Intracellular Iron Metabolism
Abboud, S., & Haile, D. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000713200 · Cited by 1,267 · see citing works
Self-citationMicrocytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene
Fleming, M. D., Trenor, C. C., Su, M. A., Foernzler, D., Beier, D. R., Dietrich, W. F., & Andrews, N. C. (1997) · Nature Genetics · doi:10.1038/ng0897-383 · Cited by 1,159 · see citing works
Vulpe, C. D., Kuo, Y.-M., Murphy, T. L., Cowley, L., Askwith, C., Libina, N., Gitschier, J., & Anderson, G. J. (1999) · Nature Genetics · doi:10.1038/5979 · Cited by 1,084 · see citing works
Fleming, M. D., Romano, M. A., Su, M. A., Garrick, L. M., Garrick, M. D., & Andrews, N. C. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.3.1148 · Cited by 936 · see citing works
Autosomal-dominant hemochrom-atosis is associated with a mutation in the ferroportin (SLC11A3) gene
Montosi, G., Donovan, A., Totaro, A., Garuti, C., Pignatti, E., Cassanelli, S., Trenor, C. C., Gasparini, P., Andrews, N. C., & Pietrangelo, A. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13468 · Cited by 555 · see citing works
A mutation in SLC11A3 is associated with autosomal dominant hemochromatosis
Njajou, O. T., Vaessen, N., Joosse, M., Berghuis, B., van Dongen, J. W. F., Breuning, M. H., Snijders, P. J. L. M., Rutten, W. P. F., Sandkuijl, L. A., Oostra, B. A., et al. (2001) · Nature Genetics · doi:10.1038/90038 · Cited by 492 · see citing works
Canonne-Hergaux, F., Gruenheid, S., Ponka, P., & Gros, P. (1999) · Blood · doi:10.1182/blood.v93.12.4406 · Cited by 451 · see citing works
Cytokine-mediated regulation of iron transport in human monocytic cells
Ludwiczek, S., Aigner, E., Theurl, I., & Weiss, G. (2003) · Blood · doi:10.1182/blood-2002-08-2459 · Cited by 420 · see citing works
Flemming (1998) · Medical Entomology and Zoology · Cited by 412 · see citing works
Pietrangelo, A. (2003) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2003.08.003 · Cited by 380 · see citing works
Cochrane, C. G., Spragg, R. G., & Revak, S. D. (1983) · Journal of Clinical Investigation · doi:10.1172/jci110823 · Cited by 338 · see citing works
OXIDANT ACTIVITY IN EXPIRED BREATH OF PATIENTS WITH ADULT RESPIRATORY DISTRESS SYNDROME
Baldwin, S. R., Grum, C. M., Boxer, L. A., Simon, R., Ketai, L. H., & Devall, L. J. (1986) · The Lancet · doi:10.1016/s0140-6736(86)91895-7 · Cited by 330 · see citing works
Zoller, H., Weiss, G., Theurl, I., Koch, R. O., Vogel, W., Obrist, P., Pietrangelo, A., Montosi, G., & Haile, D. J. (2001) · Gastroenterology · doi:10.1053/gast.2001.24033 · Cited by 304 · see citing works
Self-citationThe G185R Mutation Disrupts Function of the Iron Transporter Nramp2
Su, M. A., Trenor, C. C., Fleming, J. C., Fleming, M. D., & Andrews, N. C. (1998) · Blood · doi:10.1182/blood.v92.6.2157 · Cited by 220 · see citing works
Crystal, R. G. (1997) · Nature Medicine · doi:10.1038/nm0497-383 · Cited by 205 · see citing works
Regulation of reticuloendothelial iron transporter MTP1 (Slc11a3) by inflammation
Yang, F., Liu, X.-B., Quinones, M., Melby, P. C., Ghio, A., & Haile, D. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201485200 · Cited by 197 · see citing works
Self-citationYang, K., Reddel, R. R., Gerwin, B. I., Miyashita, M., McMenamin, M. G., Lechner, J. F., & Harris, C. C. (1988) · Differentiation · doi:10.1111/j.1432-0436.1988.tb00592.x · Cited by 192 · see citing works
Devalia, V., Carter, K., Walker, A. P., Perkins, S. J., Worwood, M., May, A. M., & Dooley, J. S. (2002) · Blood · doi:10.1182/blood-2001-11-0132 · Cited by 188 · see citing works
Twelve Years' Experience With Bronchopulmonary Dysplasia
Edwards, D. K., V, Dyer, W. M., & Northway, W. H. (1977) · PEDIATRICS · doi:10.1542/peds.59.6.839 · Cited by 173 · see citing works
Sibille, J., Kondo, H. G., & Aisen, P. (1988) · Hepatology · doi:10.1002/hep.1840080218 · Cited by 139 · see citing works
Bronchopulmonary dysplasia: then and now.
Northway, W. H. (1990) · Archives of Disease in Childhood · doi:10.1136/adc.65.10_spec_no.1076 · Cited by 134 · see citing works
Dietary iron induces rapid changes in rat intestinal divalent metal transporter expression
Yeh, K., YEH, M. K. Y., Watkins, J. A., Rodriguez‐Paris, J., & Glass, J. (2000) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2000.279.5.g1070 · Cited by 113 · see citing works
Increased Release of Ferritin and Iron by Iron-Loaded Alveolar Macrophages in Cigarette Smokers
Wesselius, L., Nelson, M. E., & SKIKNE, B. S. (1994) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.150.3.8087339 · Cited by 110 · see citing works
Dusts causing pneumoconiosis generate OH and produce hemolysis by acting as fenton catalysts
Kennedy, T. P., Dodson, R. F., Rao, N. V., Ky, H., Hopkins, C. E., Baser, M. E., Tolley, E. A., & Hoidal, J. R. (1989) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(89)90118-5 · Cited by 103 · see citing works
The SLC40 basolateral iron transporter family (IREG1/ferroportin/MTP1)
McKie, A. T., & Barlow, D. J. (2004) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-003-1102-3 · Cited by 86 · see citing works
Iron increases expression of iron-export protein MTP1 in lung cells
Yang, F., Wang, X., Haile, D. J., Piantadosi, C. A., & Ghio, A. J. (2002) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00114.2002 · Cited by 78 · see citing works
Self-citationIron uptake and Nramp2/DMT1/DCT1 in human bronchial epithelial cells
Wang, X., Ghio, A. J., Yang, F., Dolan, K. G., Garrick, M. D., & Piantadosi, C. A. (2002) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00253.2001 · Cited by 74 · see citing works
Self-citationIron homeostasis in neuronal cells: a role for IREG1
Aguirre, P., Mena, N. P., Tapia, V., Arredondo, M., & Núñez, M. T. (2005) · BMC Neuroscience · doi:10.1186/1471-2202-6-3 · Cited by 69 · see citing works
Schapira, R. M., Ghio, A. J., Effros, R. M., Morrisey, J. F., Almagro, U. A., DAWSON, C. A., & Hacker, A. (1995) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.12.2.7865220 · Cited by 66 · see citing works
Self-citationWardrop, S. L., & Richardson, D. R. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01752.x · Cited by 65 · see citing works
Metal-dependent expression of ferritin and lactoferrin by respiratory epithelial cells
Ghio, A. J., Carter, J. D., Samet, J. M., Reed, W., Quay, J., Dailey, L. A., Richards, J. H., & Devlin, R. B. (1998) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1998.274.5.l728 · Cited by 43 · see citing works
Self-citationCellular Expression of Ceruloplasmin in Baboon and Mouse Lung During Development and Inflammation
Yang, F., Friedrichs, W. E., deGraffenried, L. A., Herbert, D. C., Weaker, F. J., Bowman, B. H., & Coalson, J. J. (1996) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.14.2.8630266 · Cited by 42 · see citing works
Self-citationDMT1 expression is increased in the lungs of hypotransferrinemic mice
Ghio, A. J., Wang, X., Silbajoris, R. A., Garrick, M. D., Piantadosi, C. A., & Yang, F. (2003) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00225.2002 · Cited by 27 · see citing works
Self-citationOxidative stress activates anion exchange protein 2 and AP-1 in airway epithelial cells
Turi, J. L., Jaspers, I., Dailey, L. A., Madden, M. C., Brighton, L. E., Carter, J. D., Nozik-Grayck, E., Piantadosi, C. A., & Ghio, A. J. (2002) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00398.2001 · Cited by 26 · see citing works
Self-citationRegulation of transferrin gene expression during lung development and injury
Yang, F., Friedrichs, W. E., & Coalson, J. J. (1997) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1997.273.2.l417 · Cited by 17 · see citing works
Self-citationIRON-BINDING AND STORAGE PROTEINS IN SPUTUM
Alexis, N. E., Richards, J. H., Carter, J. D., & Ghio, A. J. (2002) · Inhalation Toxicology · doi:10.1080/08958370252871014 · Cited by 9 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Ganz, T., & Nemeth, E. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.01.014 · Cited by 1,282 · see citing works
Hepcidin and disorders of iron metabolism
Ganz, T., & Nemeth, E. (2011) · Annual Review of Medicine · doi:10.1146/annurev-med-050109-142444 · Cited by 466 · see citing works
Delaby, C., Pilard, N., Gonçalves, A. S., Beaumont, C., & Canonne-Hergaux, F. (2005) · Blood · doi:10.1182/blood-2005-06-2398 · Cited by 283 · see citing works
Hepcidin expression and iron transport in alveolar macrophages
Nguyen, N.-B., Callaghan, K. D., Ghio, A. J., Haile, D. J., & Yang, F. (2006) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00484.2005 · Cited by 143 · see citing works
Self-citationLi, J., Kanju, P. M., Patterson, M., Chew, W. L., Cho, S., GILMOUR, I. J., Oliver, T., Yasuda, R., Ghio, A. J., Simon, S. A., et al. (2011) · Environmental Health Perspectives · doi:10.1289/ehp.1002807 · Cited by 123 · see citing works
Self-citationDisruption of iron homeostasis and lung disease
Ghio, A. J. (2008) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2008.11.004 · Cited by 122 · see citing works
Self-citationThe “Iron”-y of Iron Overload and Iron Deficiency in Chronic Obstructive Pulmonary Disease
Cloonan, S. M., Mumby, S. E., Adcock, I. M., Choi, A. M. K., Chung, K. F., & Quinlan, G. J. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201702-0311pp · Cited by 109 · see citing works
Garrick, M. D., & Garrick, L. M. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.03.018 · Cited by 102 · see citing works
Iron Homeostasis in the Lungs—A Balance between Health and Disease
Neves, J., Haider, T., Gassmann, M., & Muckenthaler, M. U. (2019) · Pharmaceuticals · doi:10.3390/ph12010005 · Cited by 94 · see citing works
Healy, C. M., Muñoz‐Wolf, N., Strydom, J., Faherty, L., Williams, N. C., Kenny, S., Donnelly, S. C., & Cloonan, S. M. (2021) · Respiratory Research · doi:10.1186/s12931-021-01722-y · Cited by 89 · see citing works
Pascolo, L., Gianoncelli, A., Schneider, G., Salomé, M., Schneider, M., Calligaro, C., Kiskinova, M., Melato, M., & Rizzardi, C. (2013) · Scientific Reports · doi:10.1038/srep01123 · Cited by 88 · see citing works
New insights into the regulation of iron homeostasis
Deicher, R., & Hörl, W. H. (2006) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2006.01633.x · Cited by 80 · see citing works
Hu, Y., Huang, Y., Zong, L., Lin, J., Liu, X., & Ning, S. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-02078-0 · Cited by 75 · see citing works
Hepcidin expression in human airway epithelial cells is regulated by interferon-γ
Frazier, M. D., Mamo, L. B., Ghio, A. J., & Turi, J. L. (2011) · Respiratory Research · doi:10.1186/1465-9921-12-100 · Cited by 64 · see citing works
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Zhang, W. Z., Butler, J. J., & Cloonan, S. M. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.07.024 · Cited by 62 · see citing works
Zhang, V., Nemeth, E., & Kim, A. (2019) · Pharmaceuticals · doi:10.3390/ph12010030 · Cited by 57 · see citing works
Beaumont, C., & Canonne‐Hergaux, F. (2005) · Transfusion Clinique et Biologique · doi:10.1016/j.tracli.2005.04.017 · Cited by 53 · see citing works
Divalent metal transporter-1 decreases metal-related injury in the lung
Ghio, A. J., Piantadosi, C. A., Wang, X., Dailey, L. A., Stonehuerner, J., Madden, M. C., Yang, F., Dolan, K. G., Garrick, M. D., & Garrick, L. M. (2005) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00154.2005 · Cited by 50 · see citing works
Self-citationChange in iron transporter expression in human term placenta with different maternal iron status
Li, Y., Yan, H., & Bai, B. (2008) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2008.02.012 · Cited by 40 · see citing works
Pulmonary Iron Homeostasis in Hepcidin Knockout Mice
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Naz, N., Malik, I. A., Sheikh, N., Ahmad, S., Khan, S., Blaschke, M., Schultze, F. C., & Ramadori, G. P. (2012) · Laboratory Investigation · doi:10.1038/labinvest.2012.52 · Cited by 33 · see citing works
Iron dyshomeostasis in Parkinson’s disease
Fuentes-Salazar, J. M., Mena, N. P., & Núñez, M. T. (2006) · Springer eBooks · doi:10.1007/978-3-211-33328-0_22 · Cited by 32 · see citing works
Ferroportin is a monomer in vivo in mice
Pignatti, E., Mascheroni, L., Sabelli, M., Barelli, S., Biffo, S., & Pietrangelo, A. (2005) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2005.11.001 · Cited by 31 · see citing works
Perez, E., Baker, J. R., Giandomenico, S. D., Kermani, P., Parker, J., Kim, K., Yang, J., Barnes, P. J., Vaulont, S., Scandura, J. M., et al. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.1901284 · Cited by 29 · see citing works
Iron Availability in Tissue Microenvironment: The Key Role of Ferroportin
Gammella, E., Correnti, M., Cairo, G., & Recalcati, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22062986 · Cited by 28 · see citing works
Iron homeostasis and its disruption in mouse lung in iron deficiency and overload
Giorgi, G., D’Anna, M. C., & Roque, M. E. (2015) · Experimental Physiology · doi:10.1113/ep085166 · Cited by 25 · see citing works
The Ferroxidase Hephaestin in Lung Cancer: Pathological Significance and Prognostic Value
Zacchi, P., Belmonte, B., Mangogna, A., Morello, G., Scola, L., Martorana, A., & Borelli, V. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.638856 · Cited by 20 · see citing works
Transition and post-transition metals in exhaled breath condensate
Ghio, A. J., Madden, M. C., & Esther, C. R. (2017) · Journal of Breath Research · doi:10.1088/1752-7163/aaa214 · Cited by 20 · see citing works
Self-citationSlevogt, H., Maqami, L. Q., Vardarova, K., Beermann, W., Hocke, A. C., Eitel, J., Schmeck, B., Weimann, A., Opitz, B., Hippenstiel, S., et al. (2008) · European Respiratory Journal · doi:10.1183/09031936.00103507 · Cited by 20 · see citing works
Expression of iron-regulators in the bone tissue of rats with and without iron overload
Li, Y., Bai, B., & Zhang, Y. (2018) · BioMetals · doi:10.1007/s10534-018-0133-3 · Cited by 20 · see citing works
Grubwieser, P., Hoffmann, A., Hilbe, R., Seifert, M., Sonnweber, T., Böck, N., Theurl, I., Weiß, G., & Nairz, M. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.875543 · Cited by 17 · see citing works
Decreased breath excretion of redox active iron in COPD: a protective failure?
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Quantitative study of iron metabolism-related genes expression in rat.
Li, Y. Q., Bai, B., Zheng, Q. Q., YAN, H. H., & Zhuang, G. H. (2013) · PubMed · doi:10.3967/bes2013.004 · Cited by 14 · see citing works
Pro-oxidant iron in exhaled breath condensate: A potential excretory mechanism
Mumby, S. E., Chung, K. F., McCreanor, J., Moloney, E. D., Griffiths, M., & Quinlan, G. J. (2011) · Respiratory Medicine · doi:10.1016/j.rmed.2011.03.021 · Cited by 12 · see citing works
Arita, A., Kita, I., & Shinoda, S. (2022) · Biological Trace Element Research · doi:10.1007/s12011-021-03053-x · Cited by 6 · see citing works
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Ma, L., Cui, Z., Wei, S., Huo, J., Dong, S., & Li, S. (2025) · Poultry Science · doi:10.1016/j.psj.2025.104947 · Cited by 4 · see citing works
MicroRNA Function in Cellular Stress Response
Sangokoya, C. (2012) · DukeSpace (Duke University)
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Slevogt, H., Maqami, L. Q., Vardarova, K., Hocke, C., Eitel, J., Schmeck, B., Weimann, A., Opitz, B., Hippenstiel, S., Suttorp, N., et al. (2008) · Pneumologie · doi:10.1055/s-2008-1074355
Inhalation as a Source of Iron in Secondary Iron Overload
Ghio, A. J. (2013) · Acta Haematologica · doi:10.1159/000354822
Self-citationReview The role of hepcidin and ferroportin in iron absorption
Oates, P. S. (2007)
Ironing Out the Host-Fungal Interaction in Airway Epithelial Cells
Lee, S. (2014) · VTechWorks (Virginia Tech)
Manganese Transport Across the Pulmonary Epithelium
Thompson, K., Kim, J., & Wessling‐Resnick, M. (2014) · Royal Society of Chemistry eBooks · doi:10.1039/9781782622383-00133
EGYPTONA: Proposal Promising Drug To Control Of COVID-19 Infection
Adel, M. M. (2020) · Open Access Journal of Biomedical Science · doi:10.38125/oajbs.000225
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Mbaekwe, U., Kenny, S., Cloonan, S. M., & Kliment, C. R. (2026) · JCI Insight · doi:10.1172/jci.insight.199953
Iron and the lung: emerging roles of iron metabolism in pulmonary disease pathogenesis and therapy
Galaris, A., Toumpanakis, D., Galaris, D., Vassilakopoulos, T., & Pantopoulos, K. (2026) · European Respiratory Review · doi:10.1183/16000617.0160-2026
McColl, E. R., Kumar, D., Jones, B. R., Marks, N., Diveley, E., Karvas, R. M., Theunissen, T. W., Kelly, J. C., & Mysorekar, I. U. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.118040
- Authors
- Yang, F., Haile, D. J., Wang, X., Dailey, L. A., Stonehuerner, J. G., & Ghio, A. J.
- Affiliations
- The University of Texas at San Antonio Health Science Center (US)
- Environmental Protection Agency (US)
- Venue
- American Journal of Physiology-Lung Cellular and Molecular Physiology
- Publisher
- American Physiological Society
- Published
- 2005-07
- Volume
- 289
- Issue
- 1
- Pages
- L14-L23
- ISSN
- 1040-0605 (ISSN-L)
- 1522-1504
- OpenAlex
- W2168157030
- Cited by
- 47
- References
- 39
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 1 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 3 · 2015: 2 · 2014: 2 · 2013: 3 · 2012: 4
- FWCI
- 2.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Lung Cellular and Molecular Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01dk053079-02, 5r01hl068842-04)
- University of Texas Health Science Center at San Antonio
- National Heart, Lung, and Blood Institute (R01HL-68842)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK-53079)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Ferroptosis and cancer prognosis
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Keywords
- ferroportin 1, apical membrane localization, airway epithelium, iron homeostasis, iron detoxification, iron transport, iron export, bronchial epithelial cells, ferritin, transferrin, intracellular trafficking
- MeSH terms
- Ferroportin, Animals, Biological Transport, Active, Cell Line, Cell Membrane, Dose-Response Relationship, Drug, Epithelial Cells, Epithelium, Ferritins, Humans, Intestinal Mucosa, Iron, Lung, Inactivation, Metabolic, Transferrin, Gene Expression, Cation Transport Proteins, Mice
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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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