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Cited by 57Iron Metabolism and DisordersFerroptosis and cancer prognosisTrace Elements in Health

Iron in Lung Pathology

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Zhang, Vida, Nemeth, Elizabeta, Kim, Airie·2019·Pharmaceuticals
DOI 10.3390/ph12010030PMC PMC6469192
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Abstract

The lung presents a unique challenge for iron homeostasis. The entire airway is in direct contact with the environment and its iron particulate matter and iron-utilizing microbes. However, the homeostatic and adaptive mechanisms of pulmonary iron regulation are poorly understood. This review provides an overview of systemic and local lung iron regulation, as well as the roles of iron in the development of lung infections, airway disease, and lung injury. These mechanisms provide an important foundation for the ongoing development of therapeutic applications.

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  • The denser layers and higher Fe concentration in smoking patients are likely due to CS complexation of Fe.

    “likely due to the CS complexation of Fe, as mentioned previously [12, 34–36]”

    From An investigation of the internal morphology of asbestos ferruginous bodies: constraining their role in the onset of malignant mesothelioma (2023) · cites this paper as [36]

    Section 3.4 (page unavailable) reports higher lung iron exposure and higher iron levels in smokers than in nonsmokers. It does not attribute those levels to cigarette-smoke complexation of iron or discuss denser layers, so the proposed explanation is unsupported. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

  • In smoking patients, Fe complexation by CS leads to more pronounced Fe mobilisation and thus a continuous supply of Fe to the AFBs.

    “in smoking patients Fe complexation by CS leads to a more pronounced Fe mobilisation [12, 34–36, 39] and thus a continuous supply of Fe to the AFBs.”

    From An investigation of the internal morphology of asbestos ferruginous bodies: constraining their role in the onset of malignant mesothelioma (2023) · cites this paper as [36]

    Section 3.4 (Chronic Obstructive Pulmonary Disease; page unavailable) reports greater lung iron exposure and higher iron levels in smokers than nonsmokers. It does not say that cigarette smoke complexes and mobilises iron, or that this provides a continuous iron supply to AFBs. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

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References 78 · Cited by 57

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Authors
Zhang, V., Nemeth, E., & Kim, A.
Affiliations
University of California, Los Angeles (US)
Corresponding author
Kim, Airie
ORCID
Venue
Pharmaceuticals
Publisher
MDPI AG
Published
2019-02-15
Volume
12
Issue
1
Pages
30
ISSN
1424-8247 (ISSN-L)
DOI
10.3390/ph12010030
PMC
PMC6469192
OpenAlex
W2913793261
Cited by
57
References
78
Citations by year
2026: 5 · 2025: 3 · 2024: 5 · 2023: 12 · 2022: 16 · 2021: 8 · 2020: 6 · 2019: 2
FWCI
1.28
Type
journal article
Language
en
Open access
Licence
Locations
  • Pharmaceuticals (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • eScholarship (California Digital Library) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
National Heart, Lung, and Blood Institute (K08-HL127293)
Topics
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Ferroptosis and cancer prognosis
  • Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Keywords
iron homeostasis, iron metabolism, pulmonary infection, airway disease, lung injury

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