The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Inhalation vs. aspiration of single-walled carbon nanotubes in C57BL/6 mice: inflammation, fibrosis, oxidative stress, and mutagenesis
Open accessAbstract
Nanomaterials are frontier technological products used in different manufactured goods. Because of their unique physicochemical, electrical, mechanical, and thermal properties, single-walled carbon nanotubes (SWCNT) are finding numerous applications in electronics, aerospace devices, computers, and chemical, polymer, and pharmaceutical industries. SWCNT are relatively recently discovered members of the carbon allotropes that are similar in structure to fullerenes and graphite. Previously, we ( 47 ) have reported that pharyngeal aspiration of purified SWCNT by C57BL/6 mice caused dose-dependent granulomatous pneumonia, oxidative stress, acute inflammatory/cytokine responses, fibrosis, and decrease in pulmonary function. To avoid potential artifactual effects due to instillation/agglomeration associated with SWCNT, we conducted inhalation exposures using stable and uniform SWCNT dispersions obtained by a newly developed aerosolization technique ( 2 ). The inhalation of nonpurified SWCNT (iron content of 17.7% by weight) at 5 mg/m 3, 5 h/day for 4 days was compared with pharyngeal aspiration of varying doses (5–20 μg per mouse) of the same SWCNT. The chain of pathological events in both exposure routes was realized through synergized interactions of early inflammatory response and oxidative stress culminating in the development of multifocal granulomatous pneumonia and interstitial fibrosis. SWCNT inhalation was more effective than aspiration in causing inflammatory response, oxidative stress, collagen deposition, and fibrosis as well as mutations of K- ras gene locus in the lung of C57BL/6 mice.
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Cites
Carbon Nanotubes--the Route Toward Applications
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Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice
Shvedova, A. A., Kisin, E. R., Mercer, R., Murray, A. R., Johnson, V. J., Potapovich, A. I., Tyurina, Y. Y., Gorelik, O., Arepalli, S., Schwegler-Berry, D., et al. (2005) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00084.2005 · Cited by 1,312
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Cited by
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Porter, D. W., Hubbs, A. F., Mercer, R. R., Wu, N., Wolfarth, M. G., Sriram, K., Leonard, S., Battelli, L., Schwegler-Berry, D., Friend, S., et al. (2010) · Toxicology · doi:10.1016/j.tox.2009.10.017 · Cited by 538
Self-citationInhalation Toxicity of Multiwall Carbon Nanotubes in Rats Exposed for 3 Months
Ma-Hock, L., Treumann, S., Strauss, V., Brill, S., Luizi, F., Mertler, M., Wiench, K., Gamer, A. O., van Ravenzwaay, B., & Landsiedel, R. (2009) · Toxicological Sciences · doi:10.1093/toxsci/kfp146 · Cited by 448
Potential Health Impact of Nanoparticles
Xia, T., Li, N., & Nel, A. E. (2009) · Annual Review of Public Health · doi:10.1146/annurev.publhealth.031308.100155 · Cited by 432
Nanoparticles and innate immunity: new perspectives on host defence
Boraschi, D., Italiani, P., Palomba, R., Decuzzi, P., Duschl, A., Fadeel, B., & Moghimi, S. M. (2017) · Seminars in Immunology · doi:10.1016/j.smim.2017.08.013 · Cited by 310
Acute inhalation toxicity of cerium oxide nanoparticles in rats
Srinivas, A., Rao, P. J., Selvam, G., Murthy, P. B., & Reddy, P. N. (2011) · Toxicology Letters · doi:10.1016/j.toxlet.2011.05.1027 · Cited by 211
Metadata
- Authors
- Shvedova, A. A., Kisin, E., Murray, A. R., Johnson, V. J., Gorelik, O., Arepalli, S., Hubbs, A. F., Mercer, R. R., Keohavong, P., Sussman, N., Jin, J., Yin, J., Stone, S., Chen, B. T., Deye, G., Maynard, A., Castranova, V., Baron, P. A., & Kagan, V. E.
- Venue
- American Journal of Physiology-Lung Cellular and Molecular Physiology
- Publisher
- American Physiological Society
- Published
- 2008-10
- Volume
- 295
- Issue
- 4
- Pages
- L552-L565
- ISSN
- 1040-0605 (ISSN-L)
- 1522-1504
- OpenAlex
- W2171741011
- Cited by
- 641
- References
- 51
- FWCI
- 32.62
- Type
- journal article
- Language
- en
- Open access
- green
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- Shvedova, A. A., Kisin, E., Murray, A. R., Johnson, V. J., Gorelik, O., Arepalli, S., Hubbs, A. F., Mercer, R. R., Keohavong, P., Sussman, N., Jin, J., Yin, J., Stone, S., Chen, B. T., Deye, G., Maynard, A., Castranova, V., Baron, P. A., & Kagan, V. E. (2008). Inhalation vs. aspiration of single-walled carbon nanotubes in C57BL/6 mice: inflammation, fibrosis, oxidative stress, and mutagenesis. American Journal of Physiology-Lung Cellular and Molecular Physiology. https://doi.org/10.1152/ajplung.90287.2008
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
