The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Nicotine and the renin-angiotensin system
Open accessAbstract
Cigarette smoking is the single most important risk factor for the development of cardiovascular and pulmonary diseases (CVPD). Although cigarette smoking has been in constant decline since the 1950s, the introduction of e-cigarettes or electronic nicotine delivery systems 10 yr ago has attracted former smokers as well as a new generation of consumers. Nicotine is a highly addictive substance, and it is currently unclear whether e-cigarettes are “safer” than regular cigarettes or whether they have the potential to reverse the health benefits, notably on the cardiopulmonary system, acquired with the decline of tobacco smoking. Of great concern, nicotine inhalation devices are becoming popular among young adults and youths, emphasizing the need for awareness and further study of the potential cardiopulmonary risks of nicotine and associated products. This review focuses on the interaction between nicotine and the renin-angiotensin system (RAS), one of the most important regulatory systems on autonomic, cardiovascular, and pulmonary functions in both health and disease. The literature presented in this review strongly suggests that nicotine alters the homeostasis of the RAS by upregulating the detrimental angiotensin-converting enzyme (ACE)/angiotensin (ANG)-II/ANG II type 1 receptor axis and downregulating the compensatory ACE2/ANG-(1–7)/Mas receptor axis, contributing to the development of CVPD.
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Cites
The pathophysiology of cigarette smoking and cardiovascular disease
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Physiology of Local Renin-Angiotensin Systems
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Nicotinic Acetylcholine Receptors and Nicotinic Cholinergic Mechanisms of the Central Nervous System
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Guidelines on nicotine dose selection for in vivo research
Matta, S. G., Balfour, D. J., Benowitz, N. L., Boyd, R. T., Buccafusco, J. J., Caggiula, A. R., Craig, C. R., Collins, A. C., Damaj, M. I., Donny, E. C., et al. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0441-0 · Cited by 824
Dysregulated Renin–Angiotensin–Aldosterone System Contributes to Pulmonary Arterial Hypertension
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Chronic Activation of the Renin-Angiotensin System Induces Lung Fibrosis
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Renin–angiotensin system: Basic and clinical aspects—A general perspective
Vargas Vargas, R. A., Varela Millán, J. M., & Fajardo Bonilla, E. (2022) · Endocrinología, Diabetes y Nutrición (English ed.) · doi:10.1016/j.endien.2022.01.005 · Cited by 51
NLRP3 inflammasome activation in COVID-19: an interlink between risk factors and disease severity
Amin, S., Aktar, S., Rahman, M. M., & Chowdhury, M. M. H. (2022) · Microbes and Infection · doi:10.1016/j.micinf.2021.104913 · Cited by 51
Titova, O. E., Baron, J. A., Michaëlsson, K., & Larsson, S. C. (2021) · BMC Medicine · doi:10.1186/s12916-021-01979-6 · Cited by 45
Metadata
- Authors
- Oakes, J. M., Fuchs, R. M., Gardner, J. D., Lazartigues, E., & Yue, X.
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 2018-11-01
- Volume
- 315
- Issue
- 5
- Pages
- R895-R906
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2885396126
- Cited by
- 312
- References
- 8
- FWCI
- 36.47
- Type
- journal article
- Language
- en
- Open access
- green
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- Oakes, J. M., Fuchs, R. M., Gardner, J. D., Lazartigues, E., & Yue, X. (2018). Nicotine and the renin-angiotensin system. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. https://doi.org/10.1152/ajpregu.00099.2018
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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